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Roy L Ax Deceased4612 Avenida Del Cazador, Tucson, AZ 85718

Known as:
Roy Cox
Related to:
Shirley A Ax 86 Barbara J Hermann 73 Mary E Bellin 66 Stephen S Ax 50 Rebecca M Forgash 54 Bryan J Ax 49 Jerrod A Ax 37 Herman Susanto 45 Paul A Bellin 64

Roy Ax Phones & Addresses

4612 Avenida Del Cazador, Tucson, AZ 85718    520-5777270   

2301 W Greenbriar Dr, Phoenix, AZ 85023   

Pima, AZ   

Maricopa, AZ   

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Roy L Ax

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Company: University of arizona Position: Professor

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Professor At University Of Arizona

Location:
Tucson, AZ
Industry:
Higher Education
Work:
University of Arizona
Professor

Publications & IP owners

Us Patents

Isolated Polynucleotide Sequences Encoding A Fertility Associated Antigen

US Patent:
6891029, May 10, 2005
Filed:
Jul 16, 2001
Appl. No.:
09/905114
Inventors:
Huanmin Zhang - Tucson AZ, US
Roy L. Ax - Tucson AZ, US
Mary E. Bellin - Tucson AZ, US
Assignee:
The Arizona Board of Regents on behalf of the University of Arizona - Tucson AZ
International Classification:
C07H021/04
C12N015/63
C12N015/09
C12N015/74
C12N005/00
US Classification:
536 235, 4353201, 435 693, 435455, 435471, 435325
Abstract:
The present invention provides an isolated polynucleotide sequence and amino acid sequence for a bovine fertility associated antigen (FAA), methods of producing recombinant bovine FAA protein; methods of increasing the stability of the plasma membrane, acrosome, and/or other portions of a sperm cell by mixing with FAA and/or recombinant FAA protein(s); and increasing fertility of bulls by mixing sperm cells with FAA and/or recombinant FAA protein(s).

Fertility-Related Proteins, And Methods Of Use Thereof

US Patent:
2001000, Jul 19, 2001
Filed:
Apr 7, 1998
Appl. No.:
09/055671
Inventors:
ROY AX - TUCSON AZ, US
MARY BELLIN - TUCSON AZ, US
TOD MCCAULEY - TUCSON AZ, US
International Classification:
A61K039/395
C07K016/00
C12P021/08
US Classification:
435/007100, 424/143100, 424/141100, 424/130100, 530/388220, 530/388100
Abstract:
Two new heparin-binding proteins (HBP) in bovine seminal fluid are characterized. Both proteins are strongly correlated with enhanced fertility. The first protein exhibits a molecular mass of 31-kDa in SDS-PAGE electrophoresis, and has an N-terminal sequence, as well as internal sequences, closely correlated with deoxyribonuclease I-like protein. The second protein is identified as a tissue inhibitor of metalloproteinases, and has a 24-kDa molecular mass in SDS-PAGE electrophoresis under reducing conditions, and a 21.5 kDa under non-reducing conditions. N-terminal sequence information for both proteins is provided. Assays for these proteins may be employed to indicate bulls of higher fertility.

Fertility Associated Antigens And Method Of Use Thereof

US Patent:
2003021, Nov 13, 2003
Filed:
Mar 31, 2003
Appl. No.:
10/240721
Inventors:
Huanmin Zhang - Okemos MI, US
Roy Ax - Tucson AZ, US
International Classification:
A01N001/02
C07H021/04
C12P021/02
C12N001/21
C12N005/06
C07K014/47
US Classification:
435/002000, 435/069300, 435/252300, 435/320100, 435/325000, 536/023500, 530/350000
Abstract:
The present invention relates to a gene encoding a fertility associated antigen methods of employing the fertility associated antigen to stabilize sperm and/or increase the fertility of a male and method of assessing, the fertility and/or reproductive fitness of a male

Fertility Prediction Of Mammalian Males And Polyclonal Antibodies For The Prediction Thereof

US Patent:
2005004, Mar 3, 2005
Filed:
Aug 29, 2003
Appl. No.:
10/650791
Inventors:
Roy Ax - Tucson AZ, US
Tod McCauley - Tucson AZ, US
George Dawson - Tucson AZ, US
Huanmin Zhang - Okemos MI, US
Assignee:
The Arizona Board of Regents... - Tucson AZ
International Classification:
C07K016/18
G01N033/53
G01N033/567
US Classification:
530388100, 435007200
Abstract:
The present invention relates to polyclonal antibodies directed to mammalian FAA and methods of detecting the presence of FAA in semen by polyclonal antibody assay. This invention pertains to methods of predicting which candidates within a male mammalian population are likely to be the most fertile, by assaying for the presence and/or localization of FAA by utilizing polyclonal antibodies generated against recombinant FAA.

Composition And Method To Increase Mammalian Sperm Function

US Patent:
2007016, Jul 19, 2007
Filed:
Jan 19, 2007
Appl. No.:
11/624799
Inventors:
Tod McCauley - Tucson AZ, US
Huanmin Zhang - Okemos MI, US
Roy Ax - Tucson AZ, US
International Classification:
A01N 1/02
US Classification:
435002000
Abstract:
A composition of matter for increasing the motility and/or percentage of intact acrosomes (PIA) in sperm is described. The composition includes, in combination, an amount of FAA and an amount of TIMP-2, wherein the amounts are effective to increase the motility, the PIA, or the motility and PIA of sperm contacted with the composition. The composition can be used as a cryopreservation medium for sperm.

Method To Diagnose And Increase Fertility Of Mammalian Semen Using Dnase As A Diagnostic Marker And Therapeutic Agent

US Patent:
2007025, Nov 8, 2007
Filed:
May 3, 2007
Appl. No.:
11/743989
Inventors:
Roy L. Ax - Tucson AZ, US
Tod C. McCauley - Tucson AZ, US
International Classification:
C12Q 1/68
US Classification:
435 6
Abstract:
A method and a corresponding composition of matter for diagnosing or increasing the fertility of semen is described. The method involves measuring DNase activity in a semen sample, wherein greater DNase activity in the semen sample indicates increased fertility of the semen sample. Also described is a corresponding composition for storing and increasing the fertility of semen. The composition includes a diluent and an amount of exogenous DNase and-or fertility-associated antigen (FAA) disposed in the diluent. The amount of the exogenous DNase and/or FAA added to the diluent is effective to increase fertility of the semen stored in the composition.

Monoclonal Antibody Detection Of Proteins On Sperm Related To Fertility

US Patent:
5962241, Oct 5, 1999
Filed:
Jun 7, 1995
Appl. No.:
8/487168
Inventors:
Roy L. Ax - Tucson AZ
Mary E. Bellin - Tucson AZ
Assignee:
The University of Arizona - Tucson AZ
International Classification:
G01N 3353
US Classification:
435 792
Abstract:
Heparin binding proteins (HBP) are produced by male accessory glands and bind to sperm at ejaculation. The ability of accessory glands to produce HBP and sperm to bind HBP differs among males. Identifying the presence of a 21. 5, 24 and 30 kDa heparin binding proteins in sperm membranes with a monoclonal antibody resulted in separating groups of bulls by 40% difference in fertility. Thus, fertility potential of a bull can be predicted by heparin binding protein content of sperm membranes.

Possible Relatives

Cynthia A Ax  Carrie L Ax  Roy L Johnson  Roy M Johnston  Roy Stanfield  Roy Stanfill  Roy Stanford  Roy E White  Roy A Jones  Roy A Stanley 

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