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Sally M Jewell, 845309 Garwood Ct, Spokane, WA 99208
Sally Jewell Phones & Addresses
5309 Garwood Ct, Spokane, WA 99208 509-4681489
Mead, WA
San Diego, CA
Gig Harbor, WA
Millington, TN
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Publications & IP owners
Us Patents
Enhanced Variants Of Erythropoietin And Methods Of Use
US Patent:
2004015, Aug 12, 2004
Filed:
Nov 7, 2003
Appl. No.:
10/705217
Inventors:
Glen Evans - San Marcos CA, US
Sally Jewell - La Jolla CA, US
Mark Ware - San Diego CA, US
Sally Jewell - La Jolla CA, US
Mark Ware - San Diego CA, US
International Classification:
C07K014/505
US Classification:
435/069100, 530/399000, 435/320100, 435/325000
Abstract:
The invention provides a human erythropoietin polypeptide variant containing a human erythropoietin amino acid sequence having an amino acid difference in two or more different Epo-modification regions and an enhanced erythropoietin activity, or a functional fragment thereof. Also provided is a human erythropoietin polypeptide variant containing a human erythropoietin amino acid sequence having an amino acid difference in two or more different Epo-modification regions and a moderated erythropoietin activity, or a functional fragment thereof. The invention further provides a composition containing a human erythropoietin polypeptide variant having an amino acid sequence selected from SEQ ID NOS: 4, 6, 8, 14, 16, 18, 26, 28, 30, 34, 36, 38, 40, 42, 44, 48, 50, 54, 56, 60, 62, 66, 68, 70, 72, 74, 76, 82, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 112, 116, 118, 120, 122, 124, 132, 134, 138, 144, 148, 150, 152, 160, 162, 164, 166, 170, 172, 174, 184, 188, 192, 194, 196, 198, 200, 206, 210, 212, 218, 220, 222, 224, and a pharmaceutically acceptable medium.
Enhanced Variants Of Erythropoietin And Methods Of Use
US Patent:
2004009, May 13, 2004
Filed:
Nov 8, 2002
Appl. No.:
10/291847
Inventors:
Glen Evans - San Marcos CA, US
Sally Jewell - La Jolla CA, US
Mark Ware - San Diego CA, US
Sally Jewell - La Jolla CA, US
Mark Ware - San Diego CA, US
International Classification:
C07K014/505
C07H021/04
C07H021/04
US Classification:
435/069100, 435/320100, 435/325000, 530/399000, 536/023500
Abstract:
The invention provides a human erythropoietin polypeptide variant containing a human erythropoietin amino acid sequence having an amino acid difference in two or more different Epo-modification regions and an enhanced erythropoietin activity, or a functional fragment thereof. Also provided is a human erythropoietin polypeptide variant containing a human erythropoietin amino acid sequence having an amino acid difference in two or more different Epo-modification regions and a moderated erythropoietin activity, or a functional fragment thereof. The invention further provides a composition containing a human erythropoietin polypeptide variant having an amino acid sequence selected from SEQ ID NOS: 4, 6, 8, 14, 16, 18, 26, 28, 30, 34, 36, 38, 40, 42, 44, 48, 50, 54, 56, 60, 62, 66, 68, 70, 72, 74, 76, 82, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 112, 116, 118, 120, 122, 124, 132, 134, 138, 144, 148, 150, 152, 160, 162, 164, 166, 170, 172, 174, 184, 188, 192, 194, 196, 198, 200, 206, 210, 212, and a pharmaceutically acceptable medium.
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