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Sam Kwong Shum, 5730 Mimosa Dr, Cos Cob, CT 06807

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30 Mimosa Dr, Cos Cob, CT 06807    203-6180306    203-6180909   

72 Sumner Ave, Staten Island, NY 10314    718-3701204   

413 Glenbrook Rd, Stamford, CT 06906    203-3238382    203-3253382   

46 Bay 34Th St, Brooklyn, NY 11214    718-4496785   

Norwalk, CT   

Greenwich, CT   

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Us Patents

Determining Percent Solids In Suspension Using Raman Spectroscopy

US Patent:
2013005, Feb 28, 2013
Filed:
May 4, 2011
Appl. No.:
13/696650
Inventors:
Jason J. Antunovich - Danbury CT, US
Arthur T. Hamfeldt - Poughquag NY, US
Rodney J. Woods - New Milford CT, US
Sam C. Shum - New Milford CT, US
Assignee:
MannKind Corporaation - Valencia CA
International Classification:
G01J 3/44
US Classification:
356301
Abstract:
Methods and apparatus are provided for determining weight percent of solids in a suspension using Raman spectroscopy. The methods can be utilized to acquire Raman spectral data from the suspension and to determine weight percent of solids in a process being carried out, for example, in a vessel, without the need to remove samples for analysis. The weight percent of the solids can be determined with a desired accuracy in a relatively short time, typically 10 minutes or less. The acquired Raman spectral data may be processed by chemometric software using, for example, a Partial Least Squares algorithm and data pretreatment to provide a predicted value of weight percent solids. In some embodiments, the invention is used to determine the weight percent of microparticles of a diketopiperazine in an aqueous solution.

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