Samuel G Michael, 4913946 Lullaby Rd, Germantown, MD 20874

6652724, Nov 25, 2003

May 18, 2001

09/859664

Samuel Michael - Silver Spring MD
Jack Goodman - Lusby MD
N. Leigh Anderson - Washington DC

Large Scale Proteomics Corporation - Germantown MD

C25B 1100

204613, 204462, 204466, 204616, 204467, 204618, 422 99

An automated high-throughput system for excising spots or samples from an electrophoresis slab gel includes a computer controlled robotic arm assembly and a sample plate handling assembly for supplying a sample plate to a loading station. The computer is connected to a scanner and imaging device to identify selected sample locations on the slab gel and to direct the robotic arm to the selected locations for excising the gel spots. The cutting assembly includes a removable tray for supporting the slab gel during the cutting process and is coupled to the automated sample plate handling assembly. The sample plate handling assembly delivers a multiwell plate to the cutting assembly for receiving the gel spots. The removable tray cooperates with a scanner for identifying protein spots and includes a positioning device to position the tray in the scanner and the cutting assembly in selected locations to coordinate the scanned image with the cutting process.

6804410, Oct 12, 2004

Apr 17, 2001

09/835814

John J. Lennon - Gaithersburg MD
Anthony James Makusky - Gaithersburg MD
Samuel G. Michael - Silver Spring MD

Large Scale Proteomics Corporation - Vacaville CA

G06K 940

382274, 250287, 436173

A mass spectrometry apparatus uses image processing of output signals of a camera in a mass spectrometer to provide feedback for directing the laser. The present invention provides for the determination of where samples have actually been deposited on a plate, and for the selection of different points for each sample, based on its structure, at which to aim a laser, during the cycle period of the mass spectrometer. Such feedback information increases the likelihood that the laser impinges samples and provides useful data.

7359574, Apr 15, 2008

Jul 27, 2004

10/901254

John J. Lennon - Blacksburg VA, US
Anthony J. Makusky - Gaithersburg MD, US
Samuel G. Michael - Silver Spring MD, US

G06K 9/40
G01J 3/28
G01N 24/00

382274, 356326, 436173

A mass spectrometry apparatus uses image processing of output signals of a camera in a mass spectrometer to provide feedback for directing the laser. The present invention provides for the determination of where samples have actually been deposited on a plate, and for the selection of different points for each sample, based on its structure, at which to aim a laser, during the cycle period of the mass spectrometer. Such feedback information increases the likelihood that the laser impinges samples and provides useful data.

2003018, Sep 25, 2003

Mar 21, 2002

10/105981

Samuel Michael - Silver Spring MD, US
L. Wallgren - Bethesda MD, US

G01N035/00
B01L003/02

422/099000, 422/100000, 436/043000, 436/181000

A method and apparatus for automatically inserting fluids into vessels, stirring the fluids within the vessels and withdrawing the stirred fluids from the vessels by vacuum. A movable arm supports fluid delivery pipettes, a stirring device and a fluid withdrawal system. A microprocessor automatically controls the alignment and operation of a movable arm and its appended operational implements.

2008025, Oct 16, 2008

Apr 11, 2008

12/101840

JOHN J. LENNON - Gaithersburg MD, US
Anthony James Makusky - Gaithersburg MD, US
Samuel G. Michael - Silver Spring MD, US

H01J 49/26

250288

A mass spectrometry apparatus uses image processing of output signals of a camera in a mass spectrometer to provide feedback for directing the laser. The present invention provides for the determination of where samples have actually been deposited on a plate, and for the selection of different points for each sample, based on its structure, at which to aim a laser, during the cycle period of the mass spectrometer. Such feedback information increases the likelihood that the laser impinges samples and provides useful data.