Joseph F Bristow, 54Wayne, NJ

8318913, Nov 27, 2012

Mar 18, 2009

12/406476

Joseph Bristow - Summerville SC, US

Agratech International, Inc. - Goose Creek SC

C08B 37/08
C07H 5/06

536 20, 536 551

A method for producing chitosan from naturally occurring chitin-containing raw material, such as crustacean shells, includes an optional pretreatment step to remove non-chitin rich organic material for example, shrimp flesh, from the raw material, e. g. , shrimp shells. The optional pretreatment is followed by a demineralization step utilizing a mild hydrochloric acid solution and a deproteination step utilizing a mild sodium hydroxide solution. The deproteination step is followed by a deacetylation step to remove the acetyl group from N-acetylglucosamine (chitin) to form an amine group, yielding d-glucosamine (chitosan). Each step is followed by a washing step and the product is dried, preferably at a temperature not in excess of about 65 C. Known purification and grinding steps may also be used to produce the final chitosan product. The process is carried out in equipment comprising a series of substantially identical or similar tanks (, etc.

2009023, Sep 24, 2009

Mar 18, 2009

12/406576

Joseph Bristow - Goose Creek SC, US
Richard M. DeMarco - Kinnelon NJ, US

B32B 17/06
B05D 3/00

428426, 427331, 427299

Glass surfaces, for example, windshield surfaces, have a durable hydrophobic coating applied thereto. The glass surface is first treated by any suitable method to enhance the ability of a chitosan polymer coating to durably or substantially permanently adhere thereto. Once the chitosan coating has been applied to the glass surface, the normally hydrophilic chitosan coating is rendered hydrophobic by suitable treatment, for example, by a combination of enzymatic and chemical treatments. Alternatively, the chitosan may be rendered hydrophobic prior to coating it on the glass surface, but that is a less preferred technique. The method of the invention provides a glass article having a hydrophobic surface.

2013033, Dec 12, 2013

Nov 26, 2012

13/684687

Joseph Bristow - Lafayette LA, US

AGRATECH INTERNATIONAL, INC. - Goose Creek SC

C08B 37/08

536 20

A method for producing chitosan from naturally occurring chitin-containing raw material, such as crustacean shells, includes an optional pretreatment step to remove non-chitin rich organic material for example, shrimp flesh, from the raw material, e.g., shrimp shells. The optional pretreatment is followed by a demineralization step utilizing a mild hydrochloric acid solution and a deproteination step utilizing a mild sodium hydroxide solution. The deproteination step is followed by a deacetylation step to remove the acetyl group from N-acetylglucosamine (chitin) to form an amine group, yielding d-glucosamine (chitosan). Each step is followed by a washing step and the product is dried, preferably at a temperature not in excess of about 65 C. Known purification and grinding steps may also be used to produce the final chitosan product. The process is carried out in equipment comprising a series of substantially identical or similar tanks ( etc.) and dryers (′), suitably interconnected.

2016023, Aug 18, 2016

Apr 28, 2016

15/141183

- Kinnelon NJ, US
Joseph Bristow - Broussard LA, US

C08B 37/08

A method for producing chitosan from naturally occurring chitin-containing raw material, such as crustacean shells, includes an optional pretreatment step to remove non-chitin rich organic material for example, shrimp flesh, from the raw material, e.g., shrimp shells. The optional pre-treatment is followed by a demineralization step utilizing a mild hydrochloric acid solution and a deproteination step utilizing a mild sodium hydroxide solution. The deproteination step is followed by a deacetylation step to remove the acetyl group from N-acetylglucosamine (chitin) to form an amine group, yielding d-glucosamine (chitosan). Each step is followed by a washing step and the product is dried, preferably at a temperature not in excess of about 65 C. Known purification and grinding steps may also be used to produce the final chitosan product. The process is carried out in equipment comprising a series of substantially identical or similar tanks ( etc.) and dryers (′), suitably interconnected.

2014037, Dec 25, 2014

Sep 5, 2014

14/478794

- Kinnelon NJ, US
Joseph Bristow - Lafayette LA, US

C08L 5/08

514 55, 536 20

Modified chitosan hemostatic agents include reverse micelles () having an outer hydrophobic shell () of suitable biocompatible hydrophobic components such as alkanes, and hydrophilic positively charged chitosan moieties () enclosed within the hydrophobic shell (). The hydrophobic shell () may be formed by attaching hydrophobic moieties to one end of chitosan polymer molecules while retaining sufficient reactive (positively charged) amine groups on the remainder of the chitosan polymers for effective blood clotting. The resulting reverse micelles () have the capability of penetrating mucous membranes such as nasal mucosa () or otherwise penetrating to bleed sites shielded or partially shielded by mucosa or other tissues. Upon exposure to red blood cells () escaping from the bleed site () the positively charged interior of the reverse micelles breaks through the hydrophobic shell () to combine with the negatively charged red blood cells () thereby clotting and attenuating or stopping the bleeding.

2014033, Nov 13, 2014

Dec 12, 2012

14/364463

- Kinnelon NJ, US
Joseph F. Bristow - Lafayette LA, US

A61K 9/107
A61K 9/00
A61K 31/722

514 54

Modified chitosan hemostatic agents include reverse micelles () having an outer hydrophobic shell () of suitable biocompatible hydrophobic components such as alkanes, and hydrophilic positively charged chitosan moieties () enclosed within the hydrophobic shell (). The hydrophobic shell () may be formed by attaching hydrophobic moieties to one end of chitosan polymer molecules while retaining sufficient reactive (positively charged) amine groups on the remainder of the chitosan polymers for effective blood clotting. The resulting reverse micelles () have the capability of penetrating mucous membranes such as nasal mucosa () or otherwise penetrating to bleed sites shielded or partially shielded by mucosa or other tissues. Upon exposure to red blood cells () escaping from the bleed site () the positively charged interior of the reverse micelles breaks through the hydrophobic shell () to combine with the negatively charged red blood cells () thereby clotting and attenuating or stopping the bleeding.