Shawn P Walsh, 4475 Wheaton Ave, Rehoboth, MA 02769

2018024, Aug 30, 2018

Feb 1, 2018

15/886568

- Rahway NJ, US
Brian Andresen - Sharon MA, US
Wonsuk Chang - Princeton NJ, US
Matthew Lloyd Childers - Medfield MA, US
Jared N. Cumming - Winchester MA, US
Andrew Marc Haidle - Somerville MA, US
Timothy J. Henderson - Natick MA, US
James P. Jewell - Newton MA, US
Rui Liang - East Brunswick NJ, US
Jongwon Lim - Lexington MA, US
Hong Liu - Kenilworth NJ, US
Min Lu - Brookline MA, US
Alan B. Northrup - Belmont CA, US
Ryan D. Otte - Natick MA, US
Tony Siu - Brookline MA, US
Benjamin Wesley Trotter - Medfield MA, US
Quang T. Truong - Morganville NJ, US
Shawn P. Walsh - Bridgewater NJ, US
Kake Zhao - Westfield NJ, US

Merck Sharp & Dohme Corp. - Rahway NJ

C07H 21/04
C07H 21/02
C07H 21/00
C07H 19/23
C07H 19/20
A61K 39/39
A61K 31/7084
A61K 31/708
A61K 31/7076
A61K 31/7064
A61K 31/706

A class of polycyclic compounds of general formula (I), of general formula (I′), or of general formula (I″), wherein Base, Base, Y, Y, X, X, X, X, X, X, X, X, R, R, R, R, R, R, R, R, R, R, R, R, R, and Rare defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

2018023, Aug 23, 2018

Feb 1, 2018

15/886578

- Rahway NJ, US
Brian Andresen - Sharon MA, US
Wonsuk Chang - Princeton NJ, US
Matthew Lloyd Childers - Medfield MA, US
Jared N. Cumming - Winchester MA, US
Andrew Marc Haidle - Somerville MA, US
Timothy J. Henderson - Natick MA, US
James P. Jewell - Newton MA, US
Rui Liang - East Brunswick NJ, US
Jongwon Lim - Lexington MA, US
Hong Liu - Kenilworth NJ, US
Min Lu - Brookline MA, US
Alan B. Northrup - Belmont CA, US
Ryan D. Otte - Natick MA, US
Tony Siu - Brookline MA, US
Benjamin Wesley Trotter - Medfield MA, US
Quang T. Truong - Morganville NJ, US
Shawn P. Walsh - Bridgewater NJ, US
Kake Zhao - Westfield NJ, US

Merck Sharp & Dohme Corp. - Rahway NJ

C07H 21/04
C07H 19/23
C07H 21/00
C07H 19/20
A61K 39/39
C07H 21/02
A61K 31/7076
A61K 31/708
A61K 31/706
A61K 31/7084
A61K 31/7064

A class of polycyclic compounds of general formula (I), of general formula (I′), or of general formula (I″), wherein Base, Base, Y, Y, X, X, X, X, X, X, X, X, R, R, R, R, R, R, R, R, R, R, R, R, R, and Rare defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

2017004, Feb 16, 2017

Aug 11, 2016

15/234182

- Rahway NJ, US
Brian Michael Andresen - Sharon MA, US
Wonsuk Chang - Princeton NJ, US
Matthew Lloyd Childers - Medfield MA, US
Jared N. Cumming - Garwood NJ, US
Andrew Marc Haidle - Somerville MA, US
Timothy J. Henderson - Natick MA, US
James P. Jewell - Newton MA, US
Rui Liang - East Brunswick NJ, US
Jongwon Lim - Lexington MA, US
Hong Liu - Kenilworth NJ, US
Min Lu - Brookline MA, US
Alan B. Northrup - Reading MA, US
Ryan D. Otte - Natick MA, US
Tony Siu - Brookline MA, US
Benjamin Wesley Trotter - Medfield MA, US
Quang T. Truong - Morganville NJ, US
Shawn P. Walsh - Bridgewater NJ, US
Kake Zhao - Westfield NJ, US

Merck Sharp & Dohme Corp. - Rahway NJ

C07H 21/04
C07H 19/23
C07H 19/20
C07H 21/02
A61K 39/39

A class of polycyclic compounds of general formula (I), of general formula (I′), or of general formula (I″), wherein Base, Base, Y, Y, X, X, X, X, X, X, X, X, R, R, R, R, R, R, R, R, R, R, R, R, R, and Rare defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.