Inventors:
- Oakland CA, US
Che-Ming Jack Hu - Novato CA, US
Ronnie H. Fang - San Diego CA, US
Brian T. Luk - San Diego CA, US
Kuei-Chun Wang - San Diego CA, US
Shu Chien - La Jolla CA, US
International Classification:
A61K 9/51
A61P 7/04
A61P 9/00
A61P 35/00
A61K 31/337
Abstract:
The present invention relates to prevention and/or treatment of diseases or disorders associated with a damaged or leaky vasculature in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating a disease or disorder associated with a damaged or leaky vasculature in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, an outer surface comprising a cellular membrane derived from a platelet; and optionally an agent for preventing, treating, diagnosing, or prognosing the disease or disorder and/or monitoring prevention or treatment of the disease or disorder. Exemplary diseases or disorders include hemorrhage (bleeding), cardiovascular diseases or disorders, diseases or disorders associated with narrowing of a blood vessel, tumors or cancers.
