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Seung P Kwak, 6119 Baldwin St, Pennington, NJ 08534

Related to:
Claudia S Marquez 56 Katherine J Kick 71 Knute C Kick 56

Seung Kwak Phones & Addresses

19 Baldwin St, Pennington, NJ 08534    609-7375178   

4 Hampton Ave, Ewing, NJ 08638    609-8825549   

Princeton, NJ   

Ann Arbor, MI   

Plainsboro, NJ   

Ypsilanti, MI   

4 Hampton Rd, Ewing, NJ 08638    609-8825549   

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Resumes

Seung Kwak Photo 23

Director, Molecular Sytems Biology

Location:
Ewing, NJ
Industry:
Biotechnology
Work:
Chdi Foundation Feb 2006 - Dec 2011
Director, Molecular Sytems Biology Pfizer Jan 1, 1996 - Feb 1, 2006
Principal Research Scientist and Team Leader Pfizer 2005 - 2006
Principal Research Scientist Ii University of Michigan 1991 - 1994
Post-Doc Chdi 1991 - 1994
Director, Molecular Sytems Biology
Education:
University of Michigan Medical School 1985 - 1991
Doctorates, Doctor of Philosophy, Neuroscience Oberlin College 1982 - 1985
Bachelors, Bachelor of Arts St. Mary's International School
Skills:
Drug Discovery, Biotechnology, Life Sciences, Drug Development, Molecular Biology, Research, Neuroscience, Cell Biology, Biochemistry, Leadership, Pharmaceutical Industry, Cell Culture, Validation, Cell, Lifesciences, Genetics
Seung Kwak Photo 24

Seung Kwak

Publications & IP owners

Us Patents

Antagonist Antibodies Against Gdf-8 And Uses In Treatment Of Als And Other Gdf-8 Associated Disorders

US Patent:
7910107, Mar 22, 2011
Filed:
Jul 24, 2009
Appl. No.:
12/508618
Inventors:
Frank S. Walsh - Bryn Mawr PA, US
Margaret M. Zaleska - Narberth PA, US
David S. Howland - Yardley PA, US
Erika L. F. Holzbaur-Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
William Kelley, legal representative - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Poon Kwak - Ewing NJ, US
Karen Wallace - Newton Square PA, US
Nicholas Weber - Mountaintop PA, US
Menelas N. Pangalos - Pennington NJ, US
Assignee:
WYETH LLC - Wilmington DE
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
A61K 39/395
US Classification:
4241451, 4241301, 4241331
Abstract:
The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc. , in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

Method For Treating Muscular Dystrophy Using Antagonist Antibodies Against Gdf-8

US Patent:
8349327, Jan 8, 2013
Filed:
Feb 18, 2011
Appl. No.:
13/030978
Inventors:
Frank S. Walsh - Bryn Mawr PA, US
Margaret M. Zaleska - Narberth PA, US
David S. Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
William Kelley, legal representative - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Poon Kwak - Ewing NJ, US
Menelas N. Pangalos - Pennington NJ, US
Assignee:
Wyeth LLC - Madison NJ
International Classification:
A61K 39/395
US Classification:
4241331, 4241581
Abstract:
The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc. , in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

Polynucleotides Encoding Antagonist Antibodies Against Gdf-8

US Patent:
8372625, Feb 12, 2013
Filed:
Mar 2, 2011
Appl. No.:
13/038954
Inventors:
Frank S. Walsh - Bryn Mawr PA, US
Margaret M. Zaleska - Narberth PA, US
David S. Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Xiang-Yang Tan - Reading MA, US
Seung Poon Kwak - Ewing NJ, US
Menelas N. Pangalos - Pennington NJ, US
William Kelley - Reading MA, US
Assignee:
Wyeth LLC - Madison NJ
International Classification:
C07K 16/00
C12N 5/10
C12N 1/19
C12N 15/63
C12N 1/21
C07H 21/04
C12P 21/06
US Classification:
43525233, 43525231, 4352523, 4352542, 43525421, 43525422, 4353201, 435325, 435352, 435358, 435367, 435 696, 5303871, 536 2353
Abstract:
The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc. , in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

Method For Treating Cachexia Using Antagonist Antibodies Against Gdf-8

US Patent:
8496934, Jul 30, 2013
Filed:
Dec 4, 2012
Appl. No.:
13/693995
Inventors:
Margaret M. Zaleska - Narberth PA, US
David S. Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Poon Kwak - Ewing NJ, US
Menelas N. Pangalos - Pennington NJ, US
Assignee:
Wyeth LLC - Madison NJ
International Classification:
A61K 39/395
US Classification:
4241331, 4241581
Abstract:
The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc. , in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

Knock In Transgenic Mammal Containing A Non-Functional N-Terminus Of Kv Beta 1.1 Subunit

US Patent:
2003002, Jan 30, 2003
Filed:
Jul 16, 2002
Appl. No.:
10/196890
Inventors:
Seung Kwak - Princeton NJ, US
Kenneth Rhodes - Hillsborough NJ, US
Karen Marquis - Yardley PA, US
Thomas Comery - Langhorne PA, US
Roger Askew - Boxford MA, US
Michael Brandt - Flemington NJ, US
Assignee:
Wyeth - Madison NJ
International Classification:
A01K067/027
US Classification:
800/018000, 800/014000
Abstract:
This invention provides a transgenic mammal containing a defective beta 1 subunit (Kv1) of a voltage sensitive potassium channel, where the Kv1 subunit is unable to confer N-type inactivation of the K but retains the ability to co-associate with Kv1 family -subunits and thereby enhance channel surface expression. Preferably the Kv1.1 gene encoding Kv1 subunit has a mutation in all or a portion of codons 1-70 of its inactivation domain. The transgenic mammal is useful as a model for psychiatric and neurological disorders to identify anxiolytic compounds and pro-cognitive functions. The invention also provides for methods for screening and evaluating test compounds for their ability to modulate Kv1.1 activity, specifically for inactivation of a potassium channel or for co-association with -subunits.

Antagonist Antibodies Against Gdf-8 And Uses In Treatment Of Als And Other Gdf-8-Associated Disorders

US Patent:
2007008, Apr 19, 2007
Filed:
Aug 14, 2006
Appl. No.:
11/503062
Inventors:
Frank Walsh - Bryn Mawr PA, US
Margaret Zaleska - Narberth PA, US
David Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Kwak - Ewing NJ, US
Karen Wallace - Newtown Square PA, US
Nicholas Weber - Philadelphia PA, US
Menelas Pangalos - Pennington NJ, US
William Kelley - Reading MA, US
International Classification:
A61K 39/395
C07K 16/22
US Classification:
424145100, 530388250
Abstract:
The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

Molecular Targets And Compounds, And Methods To Identify The Same, Useful In The Treatment Of Neurodegenerative Diseases

US Patent:
2011007, Mar 31, 2011
Filed:
Feb 3, 2009
Appl. No.:
12/865281
Inventors:
David Frederik Fischer - Leiden, NL
Richard Antonius Jozef Janssen - Leiden, NL
Remko De Pril - Leiden, NL
Desiré Maria Petronella Catharina Van Steenhoven - Leiden, NL
Seung Kwak - Princeton NJ, US
David S. Howland - Princeton NJ, US
Ethan Signer - Princeton NJ, US
International Classification:
A61K 31/713
G01N 33/53
C40B 30/04
C07H 21/02
A61P 25/00
US Classification:
514 44 A, 436501, 435 71, 506 9, 536 245
Abstract:
The present invention relates to methods and assays for identifying agents capable of inhibiting the mutant huntingtin protein, inhibiting or reducing polyglutamine-induced protein aggregation, and/or altering huntingtin protein conformation, which inhibition is useful in the prevention, amelioration and/or treatment of neurodegenerative diseases, and protein aggregation diseases more generally. In particular, the present invention provides methods and assays for identifying agents for use in the prevention and/or treatment of Huntington's disease. The invention provides polypeptide and nucleic acid TARGETs and siRNA sequences based on these

Target Sequences And Methods To Identify The Same, Useful In Treatment Of Neurodegenerative Diseases

US Patent:
2011010, May 5, 2011
Filed:
Feb 3, 2009
Appl. No.:
12/865295
Inventors:
David Frederik Fishcher - Leiden, NL
Richard Antonius Janssen - Leiden, NL
Remko De Pril - Leiden, NL
Desiré Maria Petronella Catharina Van Steenhoven - Leiden, NL
Seung Kwak - Princeton NJ, US
David S. Howland - Princeton NJ, US
Ethan Signer - Princeton NJ, US
International Classification:
A61K 31/713
G01N 33/68
C40B 30/04
C07H 21/02
C07H 21/00
C12N 15/85
C12N 15/861
C12N 15/86
C12N 15/869
C12N 15/867
C12N 5/071
A61K 31/7088
A61P 25/28
A61P 25/16
A61P 25/00
US Classification:
514 44 A, 435 71, 506 9, 536 245, 536 231, 4353201, 435375, 514 44 R
Abstract:
The present invention relates to methods and assays for identifying agents capable of inhibiting the mutant huntingtin protein, inhibiting or reducing cell death, in particular cell death associated with polyglutamine-induced protein aggregation, which inhibition is useful in the prevention, amelioration and/or treatment of neurodegenerative diseases, and Huntington's disease more generally. In particular, the present invention provides methods and assays for identifying agents for use in the prevention and/or treatment of Huntingtons disease. The invention provides polypeptide and nucleic acid TARGETs and siRNA sequences based on these TARGETS.

Possible Relatives

Daniel S Kwak  Doo S Kwak  Duk W Kwak  Eugene Kwak  Eunice H Kwak  Eunju K Kwak  Gina H Kwak  Seung C Kang  Seung K Kim  Seung H Lee 

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