Inventors:
Eifion Phillips - Rochester NY
Robert Mack - Rochester NY
John Macor - Flemington NJ
Simon Semus - Bensalem PA
Assignee:
AstraZeneca AB - Sodertalje
International Classification:
C07D49122
US Classification:
544 70, 544230, 546 14, 546 18, 540543
Abstract:
A compound of formula wherein n is 0 or 1; m is 0 or 1; p is 0 or 1; X is oxygen or sulfur; Y is CH, N or NO; W is oxygen, H or F ; A is N or C(R ); G is N or C(R ); D is N or C(R ); with the proviso that no more than one of A, G, and D is nitrogen, but at least one of Y, A, G, and D is nitrogen or NO; R is hydrogen or C to C alkyl; R , R , and R are independently hydrogen, halogen, C , C alkyl, C , C alkenyl, C alkynyl, aryl, heteroaryl, OH, OC , C alkyl, CO R , âCN, âNO , âNR R , âCF , âOSO CF or R and R , or R and R , respectively, may together form another six membered aromatic or heteroaromatic ring sharing A and G, or G and D, respectively, containing between zero and two nitrogen atoms, and substituted with one to two of the following substituents: independently hydrogen, halogen, C -C alkyl, C -C alkenyl, C -C alkynyl, aryl, heteroaryl, OH, OC -C alkyl, CO R , âCN, âNO , âNR R , âCF , âOSO CF ; R and R are independently hydrogen, C -C alkyl, C(O)R , C(O)NHR , C(O)OR , SO R or may together be (CH ) Q(CH ) where Q is O, S, NR , or a bond; j is 2 to 7, k is 0 to 2; R , R , R , R , and R are independently C -C alkyl, aryl, or heteroaryl, or an enantiomer thereof, and the pharmaceutically acceptable salts thereof, processes for preparing them, composition containing them, and their use in therapy, especially in the treatment or prophylaxis of psychotic disorders and intellectual impairment disorders.
