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Sofia Patricia Becerra, 716218 Stoneham Ct, Bethesda, MD 20817

Known as:
Sofia P Becerra Sofia P Beccerra Patricia S Becerra Sofia P B Notario Sofia Debecerra
Related to:
Michael W Brassard 68

Sofia Becerra Phones & Addresses

6218 Stoneham Ct, Bethesda, MD 20817   

Washington, DC   

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Sofia Maridalma Siguenza Becerra

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Mining & Metals
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Us Patents

Retinal Pigmented Epithelium Derived Neurotrophic Factor And Methods Of Use

US Patent:
6451763, Sep 17, 2002
Filed:
Aug 29, 1995
Appl. No.:
08/520373
Inventors:
Gerald J. Chader - Bethesda MD
Sofia Patricia Becerra - Bethesda MD
Ignacio R. Rodriguez - Rockville MD
Fintan R. Steele - Washington DC
Lincoln V. Johnson - Pasadena CA
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
A61K 3818
US Classification:
514 12, 514 2
Abstract:
The present invention relates to a purified retinal pigmented epithelium derived neurotrophic factor composition and a method for purifying such a retinal pigmented epithelium neurotrophic factor. The present invention also relates to a recombinant DNA molecule comprising a gene encoding a retinal pigmented epithelium derived neurotrophic factor having the DNA sequence or the amino acid sequence in SEQ ID NO:1 and to an organism transformed with the recombinant DNA molecule. In addition, the present invention relates to a method of treating tumors, ocular diseases, nerve injuries, and conditions resulting from the activity of serine proteases, which comprises administering PEDF.

Pigment Epithelium-Derived Factor: Sequence Of The Pedf Gene

US Patent:
7179621, Feb 20, 2007
Filed:
Aug 1, 2000
Appl. No.:
09/630629
Inventors:
Gerald J. Chader - Bethesda MD, US
Ignacio R. Rodriguez - Rockville MD, US
Sofia Patricia Becerra - Bethesda MD, US
Fintan R. Steele - Washington DC, US
Lincoln V. Johnson - Pasadena CA, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
C12N 15/18
C12N 15/79
C12N 15/63
C12N 1/21
US Classification:
435 694, 435325, 4352523, 4352401, 536 2351
Abstract:
Nucleic acids encoding the neurotrophic protein known as pigment epithelium derived factor (PEDF), a truncated version of PEDF referred to as rPEDF, and equivalent proteins, vectors comprising such nucleic acids, host cells into which such vectors have been introduced, recombinant methods for producing PEDF, rPEDF, and equivalent proteins, the rPEDF protein and equivalent proteins of rPEDF and PEDF-BP, -BX and BA, and the PEDF protein produced by recombinant methods. Effects and uses of these variants on 1) neuronal differentiation (neurotrophic effect) 2) neuron survival (neuronotrophic effect) and 3) glial inhibition (gliastatic effect) are described.

Retinal Pigmented Epithelium Derived Neurotrophic Factor

US Patent:
2003009, May 22, 2003
Filed:
Aug 9, 2002
Appl. No.:
10/216373
Inventors:
Fintan Steele - Washington DC, US
Gerald Chader - Bethesda MD, US
Sofia Becerra - Bethesda MD, US
Lincoln Johnson - Pasadena CA, US
Ignacio Rodriguez - Rockville MD, US
International Classification:
A61K038/18
C07K014/475
US Classification:
514/012000, 530/399000
Abstract:
The present invention relates to a purified retinal pigmented epithelium derived neurotrophic factor composition and a method for purifying such a retinal pigmented epithelium neurotrophic factor. The present invention also relates to a recombinant DNA molecule comprising a gene encoding a retinal pigmented epithelium derived neurotrophic factor having the DNA sequence or the amino acid sequence in SEQ ID NO:1 and to an organism transformed with the recombinant DNA molecule. In addition, the present invention relates to a method of treating tumors, ocular diseases, nerve injuries, and conditions resulting from the activity of serine proteases, which comprises administering PEDF.

Pigment Epithelium-Derived Factor: Characterization, Genomic Organization And Sequence Of The Pedf Gene

US Patent:
2006000, Jan 12, 2006
Filed:
Aug 10, 2005
Appl. No.:
11/201443
Inventors:
Gerald Chader - Bethesda MD, US
Ignacio Rodriguez - Rockville MD, US
Sofia Becerra - Bethesda MD, US
Fintan Steele - Washington DC, US
Lincoln Johnson - Pasadena CA, US
Assignee:
The United States of America, As Represented by the Dept. of Health and Human Services - Rockville MD
International Classification:
C12N 5/06
C07H 21/04
C07K 14/705
US Classification:
435325000, 435069100, 435320100, 530350000, 536023500
Abstract:
Nucleic acids encoding the neurotrophic protein known as pigment epithelium-derived factor (PEDF), a truncated version of PEDF referred to as rPEDF, and equivalent proteins, vectors comprising such nucleic acids, host cells into which such vectors have been introduced, recombinant methods for producing PEDF, rPEDF, and equivalent proteins, the rPEDF protein and equivalent proteins of rPEDF and PEDF-BP, -BX and BA, and the PEDF protein produced by recombinant methods. Effects and uses of these variants on 1) neuronal differentiation (neurotrophic effect) 2) neuron survival (neuronotrophic effect) and 3) glial inhibition (gliastatic effect) are described.

Pedf-R Receptor And Uses

US Patent:
2009016, Jun 25, 2009
Filed:
Aug 5, 2004
Appl. No.:
10/566540
Inventors:
Sofia Patricia Becerra - Bethesda MD, US
Luigi Notari - North Bethesda MD, US
Jorge Laborda - Albacete, ES
Julio Escribano-Martinez - Albacete, ES
International Classification:
A61K 39/395
C07H 21/04
C07K 14/705
C12N 15/63
C12N 5/10
C12P 21/02
C07K 16/28
A61K 48/00
A61K 31/7088
A61P 25/00
C12N 5/16
G01N 33/566
C12Q 1/68
A61K 38/17
US Classification:
4241391, 536 245, 536 235, 530350, 4353201, 435325, 435 691, 5303891, 435331, 53038822, 436501, 435 6, 514 12, 514 44
Abstract:
A pigment epithelium derived factor (“PEDF”) receptor designated PEDF-R and PEDF-R encoding nucleic acid and amino acid sequences. Wild type PEDF-R, PEDF-R variants, soluble PEDF-R variants, chimeric PEDF-R, and antibodies which bind to the PEDF-R (including agonist and neutralizing antibodies), as well as various uses for these molecules are described. Assay systems for detecting ligands to PEDF-R, systems for studying the physiological role of PEDF-R and its ligands, diagnostic techniques for identifying PEDF-related conditions, therapeutic techniques for the treatment of PEDF-related and PEDF-R related conditions, and methods for identifying molecules homologous to PEDF-R.

Pigment Epithelium-Derived Factor: Characterization Of Its Novel Biological Activity And Sequences Encoding And Expressing The Protein And Methods Of Use

US Patent:
5840686, Nov 24, 1998
Filed:
Jun 7, 1994
Appl. No.:
8/257963
Inventors:
Gerald J. Chader - Bethesda MD
Sofia Patricia Becerra - Bethesda MD
Joan P. Schwartz - Bethesda MD
Takayuki Taniwaki - Koga-Machi, JP
Yukihiro Sugita - Rockville MD
Assignee:
The United States of America as represented by the Department of Health
and Human Services - Washington DC
International Classification:
A61K 3817
US Classification:
514 12
Abstract:
Nucleic acids encoding the neurotrophic protein known as pigment epithelium-derived factor (PEDF), a truncated version of PEDF referred to as rPEDF, and equivalent proteins, vectors comprising such nucleic acids, host cells into which such vectors have been introduced, recombinant methods for producing PEDF, rPEDF, and equivalent proteins, the rPEDF protein and equivalent proteins of rPEDF and PEDF -BP, -BX and BA, and the PEDF protein produced by recombinant methods Effects and uses of these variants on 1) neuronal differentiation (neurotrophic effect) 2) neuron survival (neuronotrophic effect) and 3) glial inhibition (gliastatic effect) are described.

Possible Relatives

Cynthia L Becerra  David M Becerra  Daisy M Becerra  Deborah K Becerra  Daniella Becerra  Danny S Becerra  Diana Becerra  Sofia E Johnson  Sofia L Jones  Sofia R Khawaja 

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