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Stephanie D Abraham, 30Seattle, WA

Stephanie Abraham Phones & Addresses

Seattle, WA   

Tacoma, WA   

Olympia, WA   

Beaverton, OR   

Hoolehua, HI   

6221 Nels St SW, Olympia, WA 98512    360-3520954   

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Stephanie Abraham

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Us Patents

Monoclonal Antibodies And Their Use

US Patent:
8097428, Jan 17, 2012
Filed:
Jan 20, 2011
Appl. No.:
13/010737
Inventors:
Markus Grompe - Portland OR, US
Philip R. Streeter - Portland OR, US
Craig Dorrell - Portland OR, US
Stephanie L. Abraham - Clancy MT, US
Kelsea M. Shoop - Oregon City OR, US
Assignee:
Oregon Health & Science University - Portland OR
International Classification:
G01N 33/567
US Classification:
435 721, 4353201, 435325, 435326, 435332, 536 235, 4241521, 5303871, 5303873, 5303882, 5303913, 5303917
Abstract:
Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic endocrine cells or a subset thereof, and/or a precursor thereof. Isolated monoclonal antibodies are also disclosed herein that specifically bind a cell surface antigen expressed on human pancreatic exocrine cells or human ductal cells. Humanized forms of these antibodies, and functional fragments of these antibodies, are also disclosed. The antibodies can be conjugated to an effector molecule, such as a detectable marker, a therapeutic agent, or a toxin. These antibodies are of use to detect and isolate pancreatic cells or a subset thereof. The antibodies can be used for in vitro or in vivo detection and/or isolation of pancreatic endocrine cells. Methods of treating a pancreatic tumor are also disclosed. In several examples, the isolated monoclonal antibodies bind pancreatic endocrine cells and can be used to detect diabetes or a pancreatic endocrine cell tumor.

Monoclonal Antibodies And Their Use

US Patent:
8247186, Aug 21, 2012
Filed:
Dec 13, 2011
Appl. No.:
13/324929
Inventors:
Markus Grompe - Portland OR, US
Philip R. Streeter - Portland OR, US
Craig Dorrell - Portland OR, US
Stephanie L. Abraham - Clancy MT, US
Kelsea M. Shoop - Oregon City OR, US
Assignee:
Oregon Health & Science University - Portland OR
International Classification:
G01N 33/567
US Classification:
435 721, 4353201, 435325, 435326, 435332, 5303871, 5303873, 5303882, 5303913, 5303917, 4241521, 536 235
Abstract:
Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic endocrine cells or a subset thereof, and/or a precursor thereof. Isolated monoclonal antibodies are also disclosed herein that specifically bind a cell surface antigen expressed on human pancreatic exocrine cells or human ductal cells. Humanized forms of these antibodies, and functional fragments of these antibodies, are also disclosed. The antibodies can be conjugated to an effector molecule, or a detectable marker. These antibodies are of use to detect and/or isolate pancreatic cells or a subset thereof. Methods of treating a pancreatic tumor are also disclosed.

Monoclonal Antibodies And Their Use

US Patent:
2009009, Apr 16, 2009
Filed:
Apr 27, 2007
Appl. No.:
12/298761
Inventors:
Markus Grompe - Portland OR, US
Philip R. Streeter - Oregon City OR, US
Craig Dorrell - Portland OR, US
Stephanie L. Abraham - Clancy MT, US
Kelsea M. Lanxon-Cookson - Oregon City OR, US
International Classification:
A61K 39/395
C07K 16/18
C12N 15/11
G01N 33/53
G01N 33/574
C12N 15/00
C12N 5/06
US Classification:
4241521, 5303882, 5303911, 5303913, 5303917, 536 2353, 4353201, 435331, 435 721, 435375, 435 723, 435378
Abstract:
Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic endocrine cells or a subset thereof, and/or a precursor thereof. Isolated monoclonal antibodies are also disclosed herein that specifically bind a cell surface antigen expressed on human pancreatic exocrine cells or human ductal cells. Humanized forms of these antibodies, and functional fragments of these antibodies, are also disclosed. The antibodies can be conjugated to an effector molecule, such as a detectable marker, a therapeutic agent, or a toxin. These antibodies are of use to detect and isolate pancreatic cells or a subset thereof. The antibodies can be used for in vitro or in vivo detection and/or isolation of pancreatic endocrine cells. Methods of treating a pancreatic tumor are also disclosed. In several examples, the isolated monoclonal antibodies bind pancreatic endocrine cells and can be used to detect diabetes or a pancreatic endocrine cell tumor.

Isbn (Books And Publications)

The Boxer: An Owner'S Guide To A Happy Healthy Pet

Author:
Stephanie Abraham
ISBN #:
0876053940

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