Steven F Bolling, 693111 Daleview Dr, Ann Arbor, MI 48105

6387037, May 14, 2002

Dec 23, 1999

09/470841

Steven F. Bolling - Ann Arbor MI
Morteza Gharib - San Marino CA
Gabriel Aldea - Seattle WA
Mary Lynn Gaddis - Newport Beach CA
Anthony J. Viole - Foothill Ranch CA

Orqis Medical Corporation - Lake Forest CA

A61M 110

600 16, 600 17

An extracardiac pumping system and method for using it supplement the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patients heart. A battery powered pump may be implanted subcutaneously and attached to an inflow conduit fluidly coupled to a patients femoral artery via a subcutaneous anastomosis connection. The pump draws blood from the inflow conduit and discharges it through an outflow conduit fluidly coupled to a second peripheral artery via another subcutaneous anastomosis connection. The battery may be charged extracorporeally and the pump may be operated in either a continuous or pulsatile fashion in synchronization with the patients heart. The conduits can be housed in a multi-lumen catheter and a reservoir may be provided which fluidly communicates with the inflow conduits. An additional feature may keep blood traveling extracorporeally within the system at or near body temperature.

6390969, May 21, 2002

Apr 21, 2000

09/552979

Steven F. Bolling - Ann Arbor MI
Morteza Gharib - San Marino CA
Gabriel Aldea - Seattle WA
Mary Lynn Gaddis - Newport Beach CA
Anthony Viole - Foothill Ranch CA

Orqis Medical Corporation - Lake Forest CA

A61M 110

600 16, 600 17

An extracardiac pumping for supplementing the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patients heart, and method of using same. One embodiment of the extracardiac system comprises an implantable or portable subcardiac pump, whereby the pump draws blood through an inflow conduit fluidly coupled to a non-primary artery via a cannula and discharges blood through an outflow conduit fluidly coupled to a second non-primary artery via a cannula, wherein at least one of the cannulas projects well into the patients vascular system. The pump may be operated continuously or in a pulsatile fashion, synchronous with the patients heart, thereby potentially reducing the afterload of the heart.

6428464, Aug 6, 2002

Apr 9, 1999

09/289231

Steven F. Bolling - Ann Arbor MI

Orqis Medical Corporation - Lake Forest CA

A61M 110

600 16

An extracardiac pumping for supplementing the circulation of blood through a patient without any component thereof being connected to the patients heart, and method of using same. The extracardiac system comprises a pump implanted subcutaneously at or about the patients groin in a minimally-invasive procedure, wherein the pump is powered by a battery, and means for charging the battery extracorporeally, wherein the pump draws blood through an inflow conduit fluidly coupled to the patients femoral artery via a subcutaneous anastomosis connection, and discharges blood through an outflow conduit fluidly coupled to a peripheral artery that stems from the patients aortic arch via a subcutaneous anastomosis connection. The pump may be operated continuously or in a pulsatile fashion, synchronous with the patients heart, thereby potentially reducing the pumping load on the heart.

6610004, Aug 26, 2003

Feb 15, 2002

10/078260

Anthony Viole - Foothill Ranch CA
Laksen Sirimanne - Irvine CA
Steven F. Bolling - Ann Arbor MI
Shawn OLeary - Mission Viejo CA
Robert Pecor - Aliso Viejo CA
Ryan Kelly - San Diego CA
Wolfgang Werner - Carlsbad CA
Masoud Beizai - Laguna Hills CA

Orqis Medical Corporation - Lake Forest CA

A61M 110

600 16, 600 17

An extracardiac pumping for supplementing the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patients heart, and methods of using same. One embodiment of the intravascular extracardiac system comprises a pump with inflow and outflow conduits that are sized and configured to be implantable intravascularly through a non-primary vessel, whereby it may positioned where desired within the patients vasculature. The system comprises a subcardiac pump that may be driven directly or electromagnetically from within or without the patient. The pump is configured to be operated continuously or in a pulsatile fashion, synchronous with the patients heart, thereby potentially reducing the afterload of the heart. In another embodiment, the system is positioned extracorporeally, with the inflow conduit and outflow conduit applied percutaneously to a non-primary vessel for circulating blood to and from the non-primary vessel or between the non-primary vessel and another blood vessel within the patients vasculature.

6685621, Feb 3, 2004

Jun 11, 2002

10/171023

Steven F. Bolling - Ann Arbor MI
Ken Charhut - Lake Forest CA

Orois Medical Corporation - Lake Forest CA

A61M 110

600 16, 623 311

A method for further reducing the load on a heart suffering (ventricular size maintenance) from congestive heart failure comprising the application of a subcardiac pump having inflow and outflow conduits configured to fluidly connect to non-primary vessels in such a manner as to reduce the load on and/or the size of the heart prior to applying a device intended to reduce the stress on a wall of the ailing heart.

6805710, Oct 19, 2004

Oct 9, 2002

10/267272

Steven F. Bolling - Ann Arbor MI
Richard S. Rhee - Diamond Bar CA

Edwards Lifesciences Corporation - Irvine CA

A61F 224

623 236, 623238

An annuloplasty ring for correcting maladies of the mitral annulus that not only reshapes the annulus but also reconfigures the adjacent left ventricular muscle wall. The ring may be continuous and is made of a relatively rigid material, such as Stellite. The ring has a generally oval shape that is three-dimensional at least on the posterior side. A posterior portion of the ring rises or bows upward from adjacent sides to pull the posterior aspect of the native annulus farther up than its original, healthy shape. In doing so, the ring also pulls the ventricular wall upward which helps mitigate some of the effects of congestive heart failure. Further, one or both of the posterior and anterior portions of the ring may also bow inward.

6889082, May 3, 2005

Nov 6, 2002

10/289467

Steven F. Bolling - Ann Arbor MI, US
Anthony Viole - Foothill Ranch CA, US
Shawn O'Leary - Mission Viejo CA, US

Orqis Medical Corporation - Lake Forest CA

A61M001/10

607 16, 607 17

An extracardiac pumping for supplementing the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patient's heart, and methods of using same. One embodiment provides a vascular graft that has a first end that is sized and configured to couple to a non-primary blood vessel and a second end that is fluidly coupled to a pump to conduct blood between the pump and the non-primary blood vessel. An outflow conduit is also provided that has a first end sized and configured to be positioned within the same or different blood vessel, whether primary or non-primary, through the vascular graft. The outflow conduit is fluidly coupled to the pump to conduct blood between the pump and the patient. The vascular graft may be connected to the blood vessel subcutaneously to permit application of the extracardiac pumping system in a minimally-invasive procedure.

7048680, May 23, 2006

Jun 6, 2001

09/876281

Anthony Viole - Foothill Ranch CA, US
Laksen Sirimanne - Tustin CA, US
Steven F. Bolling - Ann Arbor MI, US
Shawn O'Leary - Mission Viejo CA, US
Wolfgang Werner - Carlsbad CA, US

Orqis Medical Corporation - Lake Forest CA

A61N 1/362

600 16, 604 43

A multilumen catheter that maximizes the blood flow into and out of the patient's vasculature while also providing for passive and/or active perfusion of tissue downstream of where the catheter resides in the vasculature. The inventive catheter comprises a proximal end, a first distal and a second distal end. Lumens extending from the proximal end to each of these distal ends provide for blood circulation within one or between two blood vessels. At least one aperture in one of the lumens positioned near the proximal end provides for active perfusion of blood to the patient's vasculature downstream of where the aperture resides in the vasculature when the catheter is inserted into the patient for treatment. The inventive catheter may comprise a third lumen positioned entirely within the patient's vasculature, providing passive perfusion of blood to the patient's vasculature downstream of where the third lumen resides in the vasculature when the catheter is inserted into the patient for treatment.