Inventors:
P. Douglas Boatman - San Diego CA, US
Benjamin R. Johnson - San Diego CA, US
Jae-Kyu Jung - San Diego CA, US
Michelle Kasem - Chula Vista CA, US
Thomas O. Schrader - San Diego CA, US
Philip J. Skinner - San Diego CA, US
Steven Colletti - Princeton Junction NJ, US
Assignee:
Arena Pharmaceuticals, Inc. - San Diego CA
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C07D 471/04
A61K 31/437
A61K 31/55
A61P 3/06
A61P 3/10
A61P 9/10
US Classification:
51421707, 514303, 546118, 540597
Abstract:
The present invention is directed to certain 3H-imidazo[4,5-b]pyridin-5-ol derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the GPR81 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of GPR81 associated disorders, for example, dyslipidemia, atherosclerosis, atheromatous disease, hypertension, coronary heart disease, stroke, insulin resistance, impaired glucose tolerance, type 2 diabetes, syndrome X, obesity, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type 1 diabetes and acne.