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Steven Jon Henriksen, 79410 Glencrest Dr, Solana Beach, CA 92075

Known as:
Steven J Henriksen Steven Dr Henriksen Steven Te Henriksen Steven D Henriksen Steven J Henricksen Steven Henrikson
Related to:
Susan Banzer Haufe 48 Edward Mccormick Colin Coffey 58 Margaret Mcloughlin 67 Constance Coffey 53 Karen Banzer

Steven Henriksen Phones & Addresses

410 Glencrest Dr, Solana Beach, CA 92075    858-7558960    619-3033395   

McMinnville, OR   

Beaverton, OR   

Camano Island, WA   

Santa Barbara, CA   

La Jolla, CA   

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Us Patents

Cortistatin: Neuropeptides

US Patent:
6479642, Nov 12, 2002
Filed:
May 15, 1997
Appl. No.:
08/857389
Inventors:
J. Gregor Sutcliffe - Cardiff CA
Luis De Lecea - Del Mar CA
Steven J. Henriksen - Solana Beach CA
George R. Siggins - Del Mar CA
Assignee:
The Scripps Research Institute - La Jolla CA
International Classification:
C07K 14575
US Classification:
530399, 530350, 530324, 530326, 530327
Abstract:
The present invention relates generally to nucleic acids encoding a novel neuropeptide designated cortistatin. The cortistatin nucleic acids, proteins and polypeptides thereof along with anti-cortistatin antibodies are useful in both screening methods, diagnostic methods and therapeutic methods related to modulation of sleep and disorders thereof.

Antibodies To Cortistatin: Neuropeptides, Compositions And Methods

US Patent:
6814967, Nov 9, 2004
Filed:
Jan 18, 2001
Appl. No.:
09/766396
Inventors:
J. Gregor Sutcliffe - Cardiff CA
Luis De Lecea - Del Mar CA
Steven J. Henriksen - Solana Beach CA
George R. Siggins - Del Mar CA
Assignee:
The Scripps Research Institute - La Jolla CA
International Classification:
A61K 39395
US Classification:
4241391, 4241331, 4241451, 4241581, 435336, 5303879, 53038824, 5303892
Abstract:
The present invention relates generally to nucleic acids encoding a novel neuropeptide designated cortistatin. The cortistatin nucleic acids, proteins and polypeptides thereof along with anti-cortistatin antibodies are useful in both screening methods, diagnostic methods and therapeutic methods related to modulation of sleep and disorders thereof.

Cortistatin: Neuropeptides, Compositions And Methods

US Patent:
2002013, Sep 19, 2002
Filed:
Jan 30, 2002
Appl. No.:
10/062375
Inventors:
J. Sutcliffe - Cardiff CA, US
Luis Lecea - Del Mar CA, US
Steven Henriksen - Solana Beach CA, US
George Siggins - Del Mar CA, US
International Classification:
C12Q001/68
A61K038/22
C07H021/04
C12P021/02
C12N005/06
C07K014/575
US Classification:
536/023500, 530/399000, 514/012000, 435/006000, 435/069100, 435/325000, 435/320100
Abstract:
The present invention relates generally to nucleic acids encoding a novel neuropeptide designated cortistatin. The cortistatin nucleic acids, proteins and polypeptides thereof along with anti-cortistatin antibodies are useful in both screening methods, diagnostic methods and therapeutic methods related to modulation of sleep and disorders thereof.

Cortistatin: Neuropeptides, Compositions And Methods

US Patent:
2005024, Nov 10, 2005
Filed:
Oct 14, 2004
Appl. No.:
10/966648
Inventors:
J. Sutcliffe - Cardiff CA, US
Luis De Lecea - Del Mar CA, US
Steven Henriksen - Solana Beach CA, US
George Siggins - Del Mar CA, US
International Classification:
C12Q001/68
C07H021/04
A61K039/395
C07K014/655
C07K016/26
US Classification:
424145100, 435006000, 435069100, 435320100, 435325000, 530350000, 530388100, 536023500
Abstract:
The present invention relates generally to nucleic acids encoding a novel neuropeptide designated cortistatin, anti-cortistatin antibodies and pharmaceutical compositions thereof. The cortistatin nucleic acids, proteins and polypeptides along with anti-cortistatin antibodies are useful in both screening methods, diagnostic methods and therapeutic methods related to modulation of sleep and disorders thereof.

Cortistatin: Neuropeptides, Compositions And Methods

US Patent:
2006004, Mar 2, 2006
Filed:
May 10, 2005
Appl. No.:
11/126772
Inventors:
J. Sutcliffe - Cardiff CA, US
Luis De Lecea - Del Mar CA, US
Steven Henriksen - Solana Beach CA, US
George Siggins - Del Mar CA, US
Assignee:
The Scripps Research Institute - La Jolla CA
International Classification:
C07K 14/575
A61K 38/22
C07H 21/04
C12P 21/06
US Classification:
530405000, 435069100, 435320100, 435325000, 514012000, 536023500
Abstract:
The present invention relates generally to nucleic acids encoding a novel neuropeptide designated cortistatin. The cortistatin nucleic acids, proteins and polypeptides thereof along with anti-cortistatin antibodies are useful in both screening methods, diagnostic methods and therapeutic methods related to modulation of sleep and disorders thereof.

Inhibitors Of Oleamide Hydrolase

US Patent:
6096784, Aug 1, 2000
Filed:
Jan 5, 1999
Appl. No.:
9/225428
Inventors:
Richard A. Lerner - La Jolla CA
Dale L. Boger - La Jolla CA
Steven J. Henriksen - Solana Beach CA
Assignee:
The Scripps Research Institute - La Jolla CA
International Classification:
A01N 3706
US Classification:
514549
Abstract:
Inhibitors of oleamide hydrolase, responsible for the hydrolysis of an endogenous sleep-inducing lipid (1, cis-9-octadecenamide) were designed and synthesized. The most potent inhibitors possess an electrophilic carbonyl group capable of reversibly forming a (thio) hemiacetal or (thio) hemiketal to mimic the transition state of a serine or cysteine protease catalyzed reaction. In particular, the tight binding. alpha. -keto ethyl ester 8 (1. 4 nM) and the trifluoromethyl ketone inhibitor 12 (1. 2 nM) were found to have exceptional inhibitory activity. In addition to the inhibitory activity, some of the inhibitors displayed agonist activity which resulted in the induction of sleep in laboratory animals.

Method For Sleep Induction

US Patent:
5612380, Mar 18, 1997
Filed:
Jan 5, 1995
Appl. No.:
8/369036
Inventors:
Richard A. Lerner - La Jolla CA
Dale Boger - La Jolla CA
Ben Cravatt - San Diego CA
Gary E. Siuzdak - San Diego CA
Steven J. Henriksen - Solana Beach CA
Assignee:
The Scripps Research Institute - La Jolla CA
International Classification:
A61K 3116
US Classification:
514627
Abstract:
Sleep may be induced by administration of fatty acid primary amides, including cis-9,10-octadecenoamide. Furthermore, sleep deprivation may be assayed by analyzing cerebrospinal fluid with respect to the presence of fatty acid primary amides, including cis-9,10-octadecenoamide. The presence of cis-9,10-octadecenoamide in cerebrospinal fluid is correlated with comparative sleep deprivation.

Inhibitors Of Oleamide Hydrolase

US Patent:
5856537, Jan 5, 1999
Filed:
Jun 26, 1996
Appl. No.:
8/670284
Inventors:
Richard A. Lerner - La Jolla CA
Dale L. Boger - La Jolla CA
Steven J. Henriksen - Solana Beach CA
Assignee:
The Scripps Research Institute - La Jolla CA
International Classification:
C07C23300
US Classification:
554 61
Abstract:
Inhibitors of oleamide hydrolase, responsible for the hydrolysis of an endogenous sleep-inducing lipid (1, cis-9-octadecenamide) were designed and synthesized. The most potent inhibitors possess an electrophilic carbonyl group capable of reversibly forming a (thio) hemiacetal or (thio) hemiketal to mimic the transition state of a serine or cysteine protease catalyzed reaction. In particular, the tight binding. alpha. -keto ethyl ester 8 (1. 4 nM) and the trifluoromethyl ketone inhibitor 12 (1. 2 nM) were found to have exceptional inhibitory activity. In addition to the inhibitory activity, some of the inhibitors displayed agonist activity which resulted in the induction of sleep in laboratory animals.

Possible Relatives

David Henriksen  Deborah S Henriksen  Donald R Henriksen  Eileen V Henriksen  Elizabeth C Henriksen  Emily Henriksen  Eric L Henriksen  Steven D Johnson  Steven B Standiford  Steven B Standley 

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