Inventors:
Judy Caron - Westwood MA, US
Thomas Wessel - Lenox MA, US
Karim Lalji - West Vancouver CA, US
Mark Varney - Laguna Niguel CA, US
Roger P. Bakale - Malvern PA, US
Surendra P. Singh - Shrewsbury MA, US
H. Scott Wilkinson - Westborough MA, US
Xiping Su - Woodbridge CT, US
Zhengxu Han - Shrewsbury MA, US
Stefan G. Koenig - Shrewsbury MA, US
Assignee:
Sunovion Pharmaceuticals Inc. - Marlborough MA
International Classification:
C07C 209/62
Abstract:
One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e. g. , menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.