Inventors:
Alan Berezov - West Hollywood CA, US
Mark I. Greene - Penn Valley PA, US
Natalie Minkovsky - Philadelphia PA, US
Zheng Cai - Wynnewood PA, US
Hongtao Zhang - Paoli PA, US
Assignee:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA - Philadelphia PA
International Classification:
A61K 31/573
A61K 31/4525
A61K 31/44
A61K 31/4184
A61K 45/06
C07D 405/06
C07D 213/76
C07D 405/04
C07J 7/00
A61K 31/505
C07D 239/42
US Classification:
514171, 514179, 5142358, 51426624, 5142664, 514275, 514320, 514349, 514394, 544332, 546196, 546297, 5483051, 552574
Abstract:
This invention is in the fields of cancer therapy. More particularly it concerns compounds which are useful agents for treating cell proliferative disorders, especially those disorders characterized by over activity and/or inappropriate activity of a EGFR, including EGFR-related cancers, particularly for expanding the efficacy of drugs previously developed for this purpose, and for methods of treatments using the compounds for this purpose.
