Teresa Mak Chan, 7923 Langdon Rd, Wayland, MA 01778

7939283, May 10, 2011

Jul 12, 2002

10/194638

Teresa Chan - Wayland MA, US
Joseph F. Lawlor - Arlington MA, US
Gordon C. Siek - Somerville MA, US
Arleen Chase - Billerica MA, US
Joseph D. Musto - Dover MA, US

Fisher Scientific Company L.L.C. - Pittsburgh PA

G01N 33/53
G01N 33/543

435 75, 435 71, 435 794, 435 792, 435 4, 436518, 436523, 436525, 436528

Assays, such as immunoassays, and related articles are disclosed.

4311690, Jan 19, 1982

Jun 14, 1979

6/048628

Robert J. Buehler - Holliston MA
Teresa H. Chan - Burlington MA
Franklin Lim - Richmond VA

Damon Corporation - Needham Heights MA

G01N 3356
A61K 4300
B01J 1302

424 1

Disclosed is a process for determining the concentration of unbound hormone, e. g. , thyroxine, cortisol, or testosterone, in a liquid sample containing hormone and protein capable of binding the hormone. The sample is incubated with antibody specific to the hormone to be detected and a distinguishable analogue of the hormone, both of which are separated from the sample by semipermeable membranes capable of excluding the passage of natural protein and antibody but which allow passage of the hormone and its analogue. Preferably, the antibody and analogue are contained in semipermeable microcapsules. Free hormone in the sample permeates the membranes and competes for sites of attachment to the antibody with the analogue. The antibody and free hormones are then separated. The amount of analogue present either in association with the antibody or in the remainder of the reaction system is indicative of the level of free hormone originally present in the sample.

4731326, Mar 15, 1988

Jun 4, 1984

6/616991

Russell E. Thompson - Marshfield MA
Robert H. Rubin - Brookline MA
Nina T. Rubin - Brookline MA
Teresa H. Chan - Burlington MA

Ortho Diagnostic Systems Inc. - Raritan NJ

G01N 33535
G01N 33545
G01N 33574
G01N 33577

435 7

Methods are provided for the detection of proximal convoluted tubule causing diseases or kidney harmful drug monitoring by detecting the presence of shed normal proximal tubule associated antigens in a body fluid such as urine. The preferred embodiment employs an ELISA sandwich format wherein one monoclonal antibody specific for a first epitopic site on said antigen is immobilized on a solid phase and a second antibody, specific for a second epitopic site on said antigen is directly or indirectly labeled.

4791067, Dec 13, 1988

Jun 25, 1987

7/066306

Mark I. Sheiman - Nanuet NY
Kwok K. Yeung - Suffern NY
Teresa H. Chan - Wayland MA

Fisher Scientific Co. - Pittsburgh PA

G01N 33546
G01N 33577

436513

An assay method and kit for a hapten such as theophylline employs a first, latex reagent and a second, antibody reagent. By using a monoclonal antibody of the IgA class in the second reagent, interference by patient rheumatoid factor is prevented.