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Ted C Judd, 5117179 Braxton St, Granada Hills, CA 91344

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17179 Braxton St, Granada Hills, CA 91344    805-8162385   

610 Geranium Ln, Simi Valley, CA 93065   

Thousand Oaks, CA   

156 Summer St, Somerville, MA 02143   

312 Prospect Rd, Fort Collins, CO 80526   

775 Lake St, Fort Collins, CO 80521   

1009 Glenmoor Dr, Fort Collins, CO 80521   

Ventura, CA   

Buffalo, NY   

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Us Patents

Beta-Secretase Modulators And Methods Of Use

US Patent:
7838676, Nov 23, 2010
Filed:
Nov 14, 2006
Appl. No.:
11/599901
Inventors:
Qiufen Xue - Newbury Park CA, US
Brian K. Albrecht - Cambridge MA, US
Denise Lyn Andersen - Simi Valley CA, US
Michael Bartberger - Sherman Oaks CA, US
James Brown - Moorpark CA, US
Ryan Brown - Belmont MA, US
Stuart C. Chaffee - Philadelphia PA, US
Yuan Cheng - Newbury Park CA, US
Michael Croghan - Thousand Oaks CA, US
Russell Graceffa - Hampton NH, US
Scott Harried - Woodland Hills CA, US
Stephen Hitchcock - Westlake Village CA, US
Randall Hungate - Camarillo CA, US
Ted Judd - Simi Valley CA, US
Matthew Kaller - Ventura CA, US
Charles Kreiman - Watertown MA, US
Daniel La - Brookline MA, US
Patricia Lopez - West Hills CA, US
Craig Masse - Cambridge MA, US
Holger Monenschein - Camarillo CA, US
Thomas Nguyen - Thousand Oaks CA, US
Thomas Nixey - Newbury Park CA, US
Vinod F. Patel - Acton MA, US
Lewis Pennington - Camarillo CA, US
Matthew Weiss - Boston MA, US
Bryant Yang - Simi Valley CA, US
Wenge Zhong - Thousand Oaks CA, US
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
C07D 498/02
C07D 401/00
US Classification:
546 18, 546115
Abstract:
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I.

Beta-Secretase Modulators And Methods Of Use

US Patent:
7872009, Jan 18, 2011
Filed:
Nov 14, 2006
Appl. No.:
11/600264
Inventors:
Brian K. Albrecht - Cambridge MA, US
Denise Lyn Andersen - Simi Valley CA, US
Michael Bartberger - Sherman Oaks CA, US
James Brown - Moorpark CA, US
Ryan Brown - Belmont MA, US
Stuart C. Chaffee - Philadelphia PA, US
Yuan Cheng - Newbury Park CA, US
Michael Croghan - Thousand Oaks CA, US
Russell Graceffa - Hampton NH, US
Scott Harried - Woodland Hills CA, US
Stephen Hitchcock - Westlake Village CA, US
Randall Hungate - Camarillo CA, US
Ted Judd - Simi Valley CA, US
Matthew Kaller - Ventura CA, US
Charles Kreiman - Watertown MA, US
Daniel La - Brookline MA, US
Patricia Lopez - West Hills CA, US
Craig Masse - Cambridge MA, US
Holger Monenschein - Camarillo CA, US
Thomas Nguyen - Thousand Oaks CA, US
Thomas Nixey - Newbury Park CA, US
Vinod F. Patel - Acton MA, US
Lewis Pennington - Camarillo CA, US
Matthew Weiss - Boston MA, US
Qiufen Xue - Newbury Park CA, US
Bryant Yang - Simi Valley CA, US
Wenge Zhong - Thousand Oaks CA, US
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
A61K 31/50
US Classification:
51425201, 544238, 544298, 544408, 546242, 549398
Abstract:
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I.

Beta-Secretase Modulators And Methods Of Use

US Patent:
7973047, Jul 5, 2011
Filed:
May 13, 2010
Appl. No.:
12/779858
Inventors:
Wenge Zhong - Thousand Oaks CA, US
Stephen Hitchcock - Westlake Village CA, US
Brian K. Albrecht - Cambridge MA, US
Michael D. Bartberger - Sherman Oaks CA, US
James Brown - Moorpark CA, US
Ryan Brown - Belmont MA, US
Stuart C. Chaffee - Philadelphia PA, US
Yuan Cheng - Newbury Park CA, US
Michael Croghan - Thousand Oaks CA, US
Russell Graceffa - Hampton NH, US
Scott Harried - Woodland Hills CA, US
Dean Hickman - Moorpark CA, US
Daniel Horne - Thousand Oaks CA, US
Randall Hungate - San Francisco CA, US
Ted Judd - Simi Valley CA, US
Matthew Kaller - Ventura CA, US
Charles Kreiman - Watertown MA, US
Daniel La - Brookline MA, US
Patricia Lopez - West Hills CA, US
Craig E. Masse - Cambridge MA, US
Thomas Nixey - Newbury Park CA, US
Vinod F. Patel - Acton MA, US
Lewis Pennington - Ventura CA, US
Matthew Weiss - Boston MA, US
Qiufen Xue - Newbury Park CA, US
Bryant Yang - Simi Valley CA, US
Holger Monenschein - Camarillo CA, US
Thomas Nguyen - Thousand Oaks CA, US
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
A61K 31/438
C07D 471/00
US Classification:
514278, 546 18
Abstract:
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I.

Beta-Secretase Modulators And Methods Of Use

US Patent:
8163766, Apr 24, 2012
Filed:
Oct 21, 2010
Appl. No.:
12/909566
Inventors:
Wenge Zhong - Thousand Oaks CA, US
Stephen A. Hitchcock - Jupiter FL, US
Vinod F. Patel - Acton MA, US
Yuan Cheng - Newbury Park CA, US
Michael Croghan - Thousand Oaks CA, US
Randall W. Hungate - Camarillo CA, US
Daniel La - Brookline MA, US
Patricia Lopez - West Hills CA, US
Matthew K. Kaller - Ventura CA, US
Holger Monenschein - Camarillo CA, US
Thomas Nguyen - Newbury Park CA, US
Thomas Nixey - Newbury Park CA, US
Lewis Pennington - Ventura CA, US
Matthew Weiss - Boston MA, US
Ted Judd - Simi Valley CA, US
Russell Graceffa - Hampton NH, US
Qiufen Xue - Newbury Park CA, US
Charles Kreiman - Watertown MA, US
Brian K. Albrecht - Cambridge MA, US
Denise Lyn Andersen - Simi Valley CA, US
Michael Bartberger - Sherman Oaks CA, US
James Brown - Moorpark CA, US
Ryan Brown - Watertown MA, US
Stuart C. Chaffee - Philadelphia PA, US
Scott Harried - Woodland Hills CA, US
Craig Masse - Cambridge MA, US
Bryant Yang - Simi Valley CA, US
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
A61K 31/436
US Classification:
514278, 546 15, 549330
Abstract:
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I.

Substituted Hydroxyethyl Amine Compounds As Beta-Secretase Modulators And Methods Of Use

US Patent:
8163909, Apr 24, 2012
Filed:
May 23, 2008
Appl. No.:
12/154513
Inventors:
Wenge Zhong - Thousand Oaks CA, US
Stephen Hitchcock - Westlake Village CA, US
Vinod F. Patel - Acton MA, US
Michael Croghan - Thousand Oaks CA, US
Thomas Dineen - Somerville MA, US
Scott Harried - Woodland Hills CA, US
Daniel Horne - Thousand Oaks CA, US
Ted Judd - Simi Valley CA, US
Matthew Kaller - Ventura CA, US
Charles Kreiman - Watertown MA, US
Patricia Lopez - West Hills CA, US
Holger Monenschein - Camarillo CA, US
Thomas Nguyen - Thousand Oaks CA, US
Matthew Weiss - Boston MA, US
Qiufen Xue - Newbury Park CA, US
Bryant Yang - Simi Valley CA, US
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
A61K 31/438
A61P 25/28
C07D 491/107
US Classification:
546 15, 514278
Abstract:
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I.

Substituted Hydroxyethyl Amine Compounds As Beta-Secretase Modulators And Methods Of Use

US Patent:
8552181, Oct 8, 2013
Filed:
Mar 1, 2012
Appl. No.:
13/410201
Inventors:
Wenge Zhong - Thousand Oaks CA, US
Stephen Hitchcock - Jupiter FL, US
Vinod F. Patel - Acton MA, US
Michael Croghan - Thousand Oaks CA, US
Thomas Dineen - Somerville MA, US
Scott Harried - Woodland Hills CA, US
Daniel Horne - Simi Valley CA, US
Ted Judd - Simi Valley CA, US
Matthew Walker - Ventura CA, US
Charles Kreiman - Watertown MA, US
Patricia Lopez - West Hills CA, US
Holger Monenschein - Jupiter FL, US
Thomas Nguyen - Thousand Oaks CA, US
Matthew Weiss - Boston MA, US
Qiufen Xue - Newbury Park CA, US
Bryant Yang - Simi Valley CA, US
Russell Graceffa - Hampton NH, US
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
C07D 471/10
C07D 491/107
C07D 495/10
US Classification:
544 70, 546 16, 546 18
Abstract:
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase activity and for the treatment of diseases, including Alzheimer's disease (AD) and related CNS conditions, mediated thereby. In one embodiment, the compounds have a general Formula I.

Beta-Secretase Modulators And Methods Of Use

US Patent:
2007018, Aug 9, 2007
Filed:
Nov 10, 2006
Appl. No.:
11/595187
Inventors:
Wenge Zhong - Thousand Oaks CA, US
Stephen Hitchcock - Westlake Village CA, US
Brian Albrecht - Cambridge MA, US
Michael Bartberger - Sherman Oaks CA, US
James Brown - Moorpark CA, US
Ryan Brown - Belmont MA, US
Stuart Chaffee - Philadelphia PA, US
Yuan Cheng - Newbury Park CA, US
Michael Croghan - Thousand Oaks CA, US
Russell Graceffa - Hampton NH, US
Scott Harried - Woodland Hills CA, US
Dean Hickman - Moorpark CA, US
Daniel Horne - Thousand Oaks CA, US
Randall Hungate - San Francisco CA, US
Ted Judd - Simi Valley CA, US
Matthew Kaller - Ventura CA, US
Charles Kreiman - Watertown MA, US
Daniel La - Brookline MA, US
Patricia Lopez - West Hills CA, US
Craig Masse - Cambridge MA, US
Holger Monenschein - Camarillo CA, US
Thomas Nguyen - Thousand Oaks CA, US
Thomas Nixey - Newbury Park CA, US
Vinod Patel - Acton MA, US
Lewis Pennington - , US
Matthew Weiss - Boston MA, US
Qiufen Xue - Newbury Park CA, US
Bryant Yang - Simi Valley CA, US
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
A61K 31/4747
A61K 31/4743
A61K 31/4741
A61K 31/4025
A61K 31/353
A61K 31/277
A61K 31/165
C07D 491/02
US Classification:
514278000, 514469000, 514422000, 514456000, 514521000, 514631000, 514302000, 514313000, 514471000, 514453000, 546115000, 546016000, 548525000, 549336000, 558410000
Abstract:
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, W, R, R, R, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

Amino-Oxazines And Amino-Dihydrothiazine Compounds As Beta-Secretase Modulators And Methods Of Use

US Patent:
2011025, Oct 13, 2011
Filed:
Mar 14, 2011
Appl. No.:
13/047693
Inventors:
Jian J. CHEN - Camarillo CA, US
Wenge ZHONG - Thousand Oaks CA, US
Bryant YANG - Simi Valley CA, US
Wenyuan QIAN - Camarillo CA, US
Patricia LOPEZ - West Hills CA, US
Ryan WHITE - Somerville MA, US
Matthew WEISS - Boston MA, US
Ted JUDD - Simi Valley CA, US
Timothy POWERS - Malibu CA, US
Yuan CHENG - Newbury Park CA, US
Thomas DINEEN - Somerville MA, US
Oleg EPSTEIN - Belmont MA, US
Jonathan LOW - Granada Hills CA, US
Isaac MARX - Somerville MA, US
Ana Elena MINATTI - Woodland Hills CA, US
Michele POTASHMAN - Cambridge MA, US
Nick A. PARAS - Glendale CA, US
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
A61K 31/547
A61P 25/28
C07D 513/10
C07D 498/20
A61K 31/5386
US Classification:
5142272, 544 71, 5142328, 544 6
Abstract:
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula Iwherein A, A, A, A, A, A, R, R, X, Y and Z of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

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