BackgroundCheck.run
Search For

Thomas R Cech, 761545 Rockmont Cir, Boulder, CO 80301

Known as:
Thomas P Cech Tom Cech Thomas Jenkins
Related to:
Jennifer N Cech 38

Thomas Cech Phones & Addresses

1545 Rockmont Cir, Boulder, CO 80301    303-4994843   

North Potomac, MD   

Edwards, CO   

Chevy Chase, MD   

11516 Morning Ride Dr, Potomac, MD 20854   

Rockville, MD   

Eagle, CO   

1545 Rockmont Cir, Boulder, CO 80305   

Social networks

Thomas R Cech

Linkedin

Work

Company: Cech labs Position: Principal investigator

Industries

Biotechnology
Get Report
Control this profile

Mentions for Thomas R Cech

Thomas Cech resumes & CV records

Resumes

Thomas Cech Photo 21

Principal Investigator

Location:
Boulder, CO
Industry:
Biotechnology
Work:
Cech Labs
Principal Investigator

Publications & IP owners

Wikipedia

Thomas Cech Photo 23

Thomas Cech

Thomas Robert ech (Czech) (December 8, 1947 in Chicago) is a Nobel Laureate in chemistry. He grew up in Iowa City, Iowa. In 1966, he entered Grinnell College where he obtained a B.A ...

Us Patents

Antisense Compositions For Detecting And Inhibiting Telomerase Reverse Transcriptase

US Patent:
6444650, Sep 3, 2002
Filed:
Mar 31, 1998
Appl. No.:
09/052919
Inventors:
Thomas R. Cech - Boulder CO
Joachim Lingner - Epalinges, CH
Toru Nakamura - Boulder CO
Karen B. Chapman - Sausalito CA
Gregg B. Morin - Palo Alto CA
Calvin B. Harley - Palo Alto CA
William H. Andrews - Richmond CA
Assignee:
Geron Corporation - Menlo Park CA
University Technology Corporation - Boulder CO
International Classification:
A01N 4304
US Classification:
514 44, 536 232, 536 235
Abstract:
The present invention provides TRT antisense oligonucleotides, methods of detecting TRT, methods of diagnosing telomerase-related conditions, methods of diagnosing and providing a prognosis for cancer, and methods of treating telomerase-related conditions, including cancer.

Human Telomerase Catalytic Subunit: Diagnostic And Therapeutic Methods

US Patent:
6475789, Nov 5, 2002
Filed:
Aug 14, 1997
Appl. No.:
08/912951
Inventors:
Thomas R. Cech - Boulder CO
Joachim Lingner - Epalinges, CH
Toru Nakamura - Boulder CO
Karen B. Chapman - Sausalito CA
Gregg B. Morin - Palo Alto CA
Calvin B. Harley - Palo Alto CA
William H. Andrews - Richmond CA
Assignee:
University Technology Corporation - Boulder CO
Geron Corporation - Menlo Park CA
International Classification:
C12N 508
US Classification:
435366, 4353201, 435 691, 536 232, 424 941
Abstract:
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis, and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.

Cells Immortalized With Telomerase Reverse Transcriptase For Use In Drug Screening

US Patent:
6617110, Sep 9, 2003
Filed:
Nov 24, 2000
Appl. No.:
09/721456
Inventors:
Thomas R. Cech - Boulder CO
Joachim Lingner - Epalinges, CH
Toru Nakamura - Boulder CO
Karen B. Chapman - Sausalito CA
Gregg B. Morin - Palo Alto CA
Calvin B. Harley - Palo Alto CA
William H. Andrews - Richmood CA
Assignee:
Geron Corporation - Menlo Park CA
University Technology Corporation - Boulder CO
International Classification:
C12G 168
US Classification:
435 6, 435194, 435 692, 435325, 435 29, 536 232
Abstract:
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.

Antisense Compositions For Detecting And Inhibiting Telomerase Reverse Transcriptase

US Patent:
6627619, Sep 30, 2003
Filed:
Sep 14, 2001
Appl. No.:
09/953052
Inventors:
Thomas R. Cech - Boulder CO
Joachim Lingner - Epalinges, CH
Toru Nakamura - Boulder CO
Karen B. Chapman - Sausalito CA
Gregg B. Morin - Palo Alto CA
Calvin B. Harley - Palo Alto CA
William H. Andrews - Richmond CA
Assignee:
Geron Corporation - Menlo Park CA
University Technology Corporation - Boulder CO
International Classification:
A01N 4304
US Classification:
514 44, 435193, 435194, 435 6, 536 232, 536 245, 536 235
Abstract:
The present invention provides TRT antisense oligonucleotides, methods of detecting TRT, methods of diagnosing telomerase-related conditions, methods of diagnosing and providing a prognosis for cancer, and methods of treating telomerase-related conditions, including cancer.

Rna Ribozyme Polymerases, Dephosphorylases, Restriction Endoribonucleases And Methods

US Patent:
6696250, Feb 24, 2004
Filed:
Oct 10, 2000
Appl. No.:
09/686341
Inventors:
Thomas R. Cech - Boulder CO
Arthur J. Zaug - Louisville CO
Michael D. Been - Durham NC
Assignee:
Competitive Technologies, Inc. - Westport CT
International Classification:
C12Q 168
US Classification:
435 6, 435 9131, 536 232
Abstract:
RNA enzymes or ribozymes can act as endoribonucleases, catalyzing the cleavage of RNA molecules with a sequence specificity of cleavage greater than that of known ribonucleases and approaching that of the DNA restriction endonucleases, thus serving as RNA sequence specific endoribonucleases. An example is a shortened form of the self-splicing ribosomal RNA intervening sequence of Tetrahymena (L-19 IVS RNA). Site-specific mutagenesis of the enzyme active site of the L-19 IVS RNA alters the substrate sequence specificity in a predictable manner, allowing a set of sequence-specific endoribonucleases to be synthesized. Varying conditions allow the ribozyme to act as a polymerase (nucleotidyltransferase), a dephosphorylase (acid phosphatase or phosphotransferase) or a sequence-specific endoribonuclease.

Protection-Of-Telomere-1 (Pot-1) Proteins

US Patent:
6753411, Jun 22, 2004
Filed:
Mar 26, 2001
Appl. No.:
09/816248
Inventors:
Peter Baumann - Boulder CO
Thomas R. Cech - Potomac MD
Assignee:
The Regents of the University of Colorado - Colorado
International Classification:
C07K 14435
US Classification:
530350, 435193, 536 231, 536 235
Abstract:
A protein identified in humans and , Pot1 , binds single-stranded telomeric DNA and both stabilizes chromosome ends and regulates telomerase activity. Compounds that stabilize or disrupt the Pot1 -DNA interaction will be useful in regulating the telomere length of a cell. Because telomere length is involved in the regulation of cellular life-span, the life-span of useful cell populations may be prolonged or undesirable cells may be caused to cease proliferation. The identification of a Pot1 protein and its encoding DNA provides methods of screening useful compounds or diagnosing illnesses that involve altered expression or structure of a Pot1 protein or gene.

Method For Detecting Polynucleotides Encoding Telomerase

US Patent:
6808880, Oct 26, 2004
Filed:
Jan 19, 2001
Appl. No.:
09/766253
Inventors:
Thomas R. Cech - Boulder CO
Joachim Lingner - Epalinges, CH
Toru Nakamura - Boulder CO
Karen B. Chapman - Sausalito CA
Gregg B. Morin - Palo Alto CA
Calvin Harley - Palo Alto CA
William H. Andrews - Richmond CA
Assignee:
Geron Corporation - Menlo Park CA
Regents of the University of Colorado - Boulder CO
International Classification:
C12Q 168
US Classification:
435 6, 536 231, 536 235, 536 2431, 536 2432, 536 2433
Abstract:
The present invention is directed to novel telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various telomerase protein subunits and motifs, including the 123 kDa and 43 kDa telomerase protein subunits of , and related sequences from Schizosaccharomyces, Saccharomyces sequences, and human telomerase. The present invention is also directed to polypeptides comprising these telomerase protein subunits, as well as functional polypeptides and ribonucleoproteins that contain these subunits.

Alteration Of Sequence Of A Target Molecule

US Patent:
6897016, May 24, 2005
Filed:
Oct 2, 1998
Appl. No.:
09/165514
Inventors:
Bruce A. Sullenger - Westminster CO, US
Thomas R. Cech - Boulder CO, US
Assignee:
The Regents of the University of Colorado - Boulder CO
International Classification:
C12Q001/68
C12P019/34
C07H021/02
US Classification:
435 6, 435 5, 435 911, 435 912, 536 231, 536 245, 514 44
Abstract:
Method for splicing a target nucleic acid molecule with a separate nucleic acid molecule. Such splicing generally causes production of a chimeric protein with advantageous features over that protein naturally produced from the target nucleic acid prior to splicing. The method includes contacting the target nucleic acid molecule with a catalytic nucleic acid molecule including the separate nucleic acid molecule. Such contacting is performed under conditions in which at least a portion of the separate nucleic acid molecule is spliced with at least a portion of the target nucleic acid molecule to form a chimeric nucleic acid molecule. In this method, the catalytic nucleic molecule is chosen so that it is not naturally associated with the separate nucleic acid molecule.

Amazon

Thomas Cech Photo 24

The Rna World, 2Nd Edition (Monograph 37) (Cold Spring Harbor Monograph)

Author:
Raymond F. Gesteland, Thomas R. Cech, John F. Atkins
Publisher:
Cold Spring Harbor Laboratory Press
Binding:
Paperback
Pages:
709
ISBN #:
0879695897
EAN Code:
9780879695897
As both an informational molecule and a catalyst, RNA may hold clues to the emergence of genetic self-replication and the origins of life. The first, 1993 edition of this important work was acclaimed as unique and authoritative. The new edition has been revised, updated, and extended, and offers a c...
Thomas Cech Photo 25

Rna Worlds: From Life's Origins To Diversity In Gene Regulation

Publisher:
Cold Spring Harbor Laboratory Press
Binding:
Hardcover
Pages:
366
ISBN #:
0879699469
EAN Code:
9780879699468
Once thought to be just a messenger that allows genetic information encoded in DNA to direct the formation of proteins, RNA (ribonucleic acid) is now known to be a highly versatile molecule that has multiple roles in cells. It can function as an enzyme, scaffold various subcellular structures, and r...
Thomas Cech Photo 26

Principles Of Water Resources: History, Development, Management, And Policy

Author:
Thomas V. Cech
Publisher:
Wiley
Binding:
Paperback
Pages:
488
ISBN #:
047148475X
EAN Code:
9780471484752
A comprehensive look at our most precious resource With its broad coverage of the history of water availability and use, as well as government development, management, and policy of water usage, Thomas Cech's Principles of Water Resources, Second Edition is ideal for students from a wide range of ba...
Thomas Cech Photo 27

Introduction To Water Resources And Environmental Issues

Author:
Karrie Lynn Pennington, Thomas V. Cech
Publisher:
Cambridge University Press
Binding:
Hardcover
Pages:
468
ISBN #:
0521869889
EAN Code:
9780521869881
How much water does the world need to support growing human populations? What factors influence water quality, droughts, floods, and waterborne diseases? What are the potential effects of climate change on the world's water resources? These questions and more are discussed in this thorough introduct...
Thomas Cech Photo 28

Principles Of Water Resources: History, Development, Management, And Policy

Author:
Thomas V. Cech
Publisher:
Wiley
Binding:
Hardcover
Pages:
576
ISBN #:
0470136316
EAN Code:
9780470136317
With all new and updated material, the third edition provides civil engineers with a complete history of water availability. It also delves into government development, management, and policy of water usage. New information is included on international water issues, water measurement, and telemetry....
Thomas Cech Photo 29

The Double Life Of Rna (Howard Hughes Medical Institute Holiday Lectures On Science)

Author:
Thomas R. Cech
Publisher:
Howard Hughes Medical Center
Binding:
DVD
In these 4 lectures, HHMI president and Nobel laureate Thomas R. Cech explains the role of RNA in cellular biology. He also discusses other implications of RNA catalysis. Lectures were given in 1995.
Thomas Cech Photo 30

Genes We Share With Yeast, Flies, Worms And Mice: New Clues To Human Health And Disease

Publisher:
Diane Pub Co
Binding:
Paperback
Pages:
100
ISBN #:
0756720192
EAN Code:
9780756720193
Genes We Share With Yeast. Diane Pub Co, 2003.
Thomas Cech Photo 31

Principles Of Water Resources: History, Development, Management, And Policy

Author:
Thomas V. Cech
Publisher:
John Wiley & Sons
Binding:
Hardcover
Pages:
488
ISBN #:
0471658103
EAN Code:
9780471658108
Principles of Water Resources: History, Development, Management, and Policy

Isbn (Books And Publications)

Molecular Biology Of Rna: Proceedings Of A Director'S Sponsors-Ucla Symposium, Held At Keystone, Colorado, April 4-10, 1988

Author:
Thomas Cech
ISBN #:
0845126938

Translational Control

Author:
Thomas Cech
ISBN #:
0879695269

Genes We Share With Yeast, Flies, Worms And Mice: New Clues To Human Health And Disease

Author:
Thomas R. Cech
ISBN #:
0756720192

The Rna World

Author:
Thomas R. Cech
ISBN #:
0879695617

The Rna World

Author:
Thomas R. Cech
ISBN #:
0879697393

Principles Of Water Resources: History, Development, And Policy

Author:
Thomas V. Cech
ISBN #:
0471438618

Possible Relatives

David L Cech  Dale G Cech  Daniel J Cech  Dennis M Cech  Erin O Cech  Frank A Cech  George L Cech  Thomas D Johnson  Thomas Stamps  Thomas W Stancil 

NOTICE: You may not use BackgroundCheck or the information it provides to make decisions about employment, credit, housing or any other purpose that would require Fair Credit Reporting Act (FCRA) compliance. BackgroundCheck is not a Consumer Reporting Agency (CRA) as defined by the FCRA and does not provide consumer reports.