Inventors:
Daniel R. Twardzik - Bainbridge Island WA
Andre Pernet - Lake Forest IL
Thomas S. Felker - Vashon WA
Stefan Paskell - Bainbridge Island WA
Assignee:
Kaleidos Pharma, Inc. - Seattle WA
International Classification:
A61K 3818
US Classification:
514 12, 514866, 530300, 530324
Abstract:
Disclosed are TGF- polypeptides, related polypeptides, fragments and mimetics thereof useful in stimulating stem cell or precursor cell proliferation, migration and differentiation. The methods of the invention are useful to treat tissue injury as well as expand stem cell populations in, or obtained from, gastrointestinal, musculoskeletal, urogenital, neurological and cardiovascular tissues. The methods include ex vivo and in vivo applications.