Thomas A Grover, 82102 Fair Way, Chelan, WA 98816

5556779, Sep 17, 1996

Feb 13, 1995

8/388252

Aditya Khindaria - Logan UT
Thomas A. Grover - Hyde Park UT
Steven D. Aust - North Logan UT

Utah State University Foundation - Logan UT

C12P 300
C02F 302

435192

This invention describes a method for catalyzing sequential reductive dehalogenation reactions on aliphatic halocarbons using free radical intermediates. More specifically, this invention involves the use of biologically derived peroxidases in the generation of a variety of oxidation or reduction agents consisting of cation radicals, anion radicals, neutral radicals, or oxygen radicals. Such oxidation and reduction agents can be employed in combination to carry out sequential reductive dehalogenation reactions on aliphatic halocarbons to thereby degrade various recalcitrant organic compounds such as organic environmental pollutants.

5389356, Feb 14, 1995

Jan 5, 1993

8/001106

Steven D. Aust - Logan UT
David P. Barr - Logan UT
Thomas A. Grover - Hyde Park UT
Manish M. Shah - Logan UT
Namhyun Chung - Logan UT

Utah State University Foundation - Logan UT

C02F 302

423659

Composition and methods for carrying out a variety of oxidation reactions, reduction reactions, or both utilizing a free radical generating catalyst, a mediator, and a reductant are disclosed, The free radical generating catalyst is generally a peroxidase obtained from living organisms, such as white rot fungi. Suitable peroxidases include lignin peroxidase, horse radish peroxidase, and lactoperoxidase. Suitable mediators include veratryl alcohol, iodine, methoxybenzenes, Mn II, and ABTS. Suitable reductants include EDTA, oxalate, hydroquinones, quinones plus quinone reductase, and hydrogen peroxide. The free radical generating catalyst is generally activated in the presence of hydrogen peroxide and reacts with the mediator to form the free radical of the mediator, which is an oxidant. The free radical of the mediator in turn reacts with the reductant to form the free radical of the reductant, which is also a reductant. The free radical oxidants and reductants can react directly with targeted substrates to carry out either oxidation or reduction reactions, or they can further react in other intermediate reactions to form additional oxidants and reductants.

5468628, Nov 21, 1995

Jan 4, 1995

8/368555

Steven D. Aust - Logan UT
David P. Barr - Logan UT
Thomas A. Grover - Hyde Park UT
Manish M. Shah - Logan UT
Namhyun Chung - Logan UT

Utah State University Foundation - Logan UT

C12P 300
C02F 302

435168

Composition and methods; for carrying out a variety of oxidation reactions, reduction reactions, or both utilizing a free radical generating catalyst, a mediator, and a reductant are disclosed. The free radical generating catalyst is generally a peroxidase obtained from living organisms, such as white rot fungi. Suitable peroxidases include lignin peroxidase, horse radish peroxidase, and lactoperoxidase. Suitable mediators include veratryl alcohol, iodine, methoxybenzenes, Mn II, and ABTS. Suitable reductants include EDTA, oxalate, hydroquinones, quinones plus quinone reductase, and hydrogen peroxide.

4089329, May 16, 1978

Mar 18, 1976

5/668020

Lucien Alfred Couvillon - Salt Lake City UT
Thomas Reaks Grover - San Francisco CA
Charles Dewitt Baker - Salt Lake City UT
William Sanford Topham - Chagrin Falls OH

University of Utah Research Institute - Salt Lake City UT

A61B 316

128 2T

A noninvasive, continuous monitoring device for measuring intraocular pressure without interference with vision or normal activity of the patient. A miniature, planar-faced pressure transducer is fixed in a protruding section of a compliant hydrogel ring which has been tooled to conform to the spherical surface of the sclera. The hydrogel ring is placed noninvasively under the eyelids within the conjunctival cul-de-sac, the transducer being located in the lower temperal quadrant. Applanation of the sclera against the planar surface of the transducer results as a consequence of pressure from the separated tissues. Intraocular pressure readings are based on the variations in resistance in the strain gage elements of the transducer caused by the applied stress to the transducer diaphragm. Data is transmitted through connecting wires to a telemetry unit which transmits the data to a receiver-transcriber console. The total system permits free, uninhibited movement by the patient during the monitoring process and provides a record of intraocular pressure as a function of time-of-day.