Thomas Mowles resumes & CV records
Resumes
Thomas Mowles
Thomas F Mowles Deceased17954 SE 125Th Cir, Summerfield, FL 34491
Thomas Mowles Phones & Addresses
17954 SE 125Th Cir, Summerfield, FL 34491 352-2450974
10682 179Th St, Summerfield, FL 34491 352-2450974
11 Pudding Stone Ln, Jefferson Township, NJ 07438 973-6976333 973-2271309
Oak Ridge, NJ
266 Changebridge Rd, Pine Brook, NJ 07058 973-2271309
Franklin, NJ
Morgan, NJ
Mentions for Thomas F Mowles
Publications & IP owners
Us Patents
Substituted Piperidinomethylindolone And Cyclopent(B)Indolone Derivatives
US Patent:
4707484, Nov 17, 1987
Filed:
Nov 25, 1986
Appl. No.:
6/934756
Inventors:
Leo Berger - Montclair NJ
Wallace M. Dairman - Manahawkin NJ
Thomas F. Mowles - Pine Brook NJ
Gary L. Olson - Westfield NJ
Wallace M. Dairman - Manahawkin NJ
Thomas F. Mowles - Pine Brook NJ
Gary L. Olson - Westfield NJ
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ
International Classification:
A61K 31395
C07D52100
C07D52100
US Classification:
514278
Abstract:
Compounds of the formula ##STR1## wherein R. sub. 1 is hydrogen, lower alkyl or acyl; R. sub. 2 and R. sub. 3 independently are lower alkyl, aralkyl or alkenyl or R. sub. 2 and R. sub. 3 together form a ring of 5 to 8 carbon atoms; R. sub. 4 is phenyl, substituted phenyl, cyclohexyl, substituted cyclohexyl, cyclopentyl, substituted cyclopentyl, cycloheptyl, or substituted cycloheptyl; R. sub. 5 is hydrogen or lower alkyl; R. sub. 6 is hydrogen, lower alkyl or acyl; and pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I and pharmaceutically acceptable acid addition salts thereof are anti-emetic agents which lack central nervous system side effects.
Growth Hormone Releasing Factor Analogs
US Patent:
4734399, Mar 29, 1988
Filed:
Oct 23, 1986
Appl. No.:
6/922572
Inventors:
Arthur M. Felix - West Caldwell NJ
Edgar P. Heimer - Sparta NJ
Thomas F. Mowles - Pine Brook NJ
Edgar P. Heimer - Sparta NJ
Thomas F. Mowles - Pine Brook NJ
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ
International Classification:
A61K 3743
C07K 710
C07K 710
US Classification:
514 12
Abstract:
The invention is directed to analogs of GRF or fragments thereof wherein the fragment is reduced in number by one to fifteen amino acids from the carboxyl end wherein the analogs have the formula: ##STR1## wherein R is desNH. sub. 2 -Tyr, Tyr, D-Tyr, Ac-Tyr, His or C. sup. alpha. -Methyl-Tyr; R. sub. 1 is Ala, N-Methyl-D-Ala or D-Ala; R. sub. 2 is Lys, Ala, Leu, Val or Ile; R. sub. 3 is Ala, Leu, Val, Ile, Nle, Nval,. beta. -Ala or. alpha. -Aib; R. sub. 4 is Lys, Ala, Leu, Val or Ile; R. sub. 5 is Met, Leu, Nle or Ile; R. sub. 6 is Asn or Ser; X is hydrogen or --COR. sub. 7 ; R. sub. 7 is hydrogen, C. sub. 1-4 alkyl or halo(C. sub. 1-4)alkyl; Y is --OR. sub. 8 or --NR. sub. 9 R. sub. 10 ; R. sub. 8 is hydrogen or C. sub. 1-5 -alkyl; R. sub. 9 and R. sub.
Growth Hormone Releasing Factor Analogs
US Patent:
4622312, Nov 11, 1986
Filed:
Sep 24, 1984
Appl. No.:
6/653163
Inventors:
Arthur M. Felix - West Caldwell NJ
Edgar P. Heimer - Sparta NJ
Thomas F. Mowles - Pine Brook NJ
Edgar P. Heimer - Sparta NJ
Thomas F. Mowles - Pine Brook NJ
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ
International Classification:
A61K 3743
C07K 710
C07K 710
US Classification:
514 12
Abstract:
Novel growth hormone releasing factor analogs in which glycine at position 15 is replaced by appropriately selected amino acids demonstrate enhanced potency for the release of growth hormone and the analogs can be administered to a subject having a deficiency of growth hormone.
Growth Hormone Releasing Factor Analogs
US Patent:
4649131, Mar 10, 1987
Filed:
Aug 6, 1985
Appl. No.:
6/762891
Inventors:
Arthur M. Felix - West Caldwell NJ
Edgar P. Heimer - Sparta NJ
Thomas F. Mowles - Pine Brook NJ
Edgar P. Heimer - Sparta NJ
Thomas F. Mowles - Pine Brook NJ
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ
International Classification:
A61K 3736
A61K 3724
C07K 710
A61K 3724
C07K 710
US Classification:
514 12
Abstract:
Novel growth hormone releasing factor analogs in which glycine at position 15 is replaced by appropriately selected amino acids demonstrate enhanced potency for the release of growth hormone and the analogs can be administered to a subject having a deficiency of growth hormone.
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