Thomas G O'Sullivan, 56Scituate, MA

2017020, Jul 27, 2017

Jan 26, 2017

15/416942

- Oakland CA, US
Bruce J. Tromberg - Irvine CA, US
Thomas D. O'Sullivan - Laguna Hills CA, US
Siavash Sedighzadeh Yazdi - Irvine CA, US
Albert Cerussi - Cupertino CA, US

The Regents of the University of California - Oakland CA

A61B 5/1455
A61B 5/00
A61B 5/08
A61B 5/145
A61B 5/024

A low cost portable high speed quantitative system for diffuse optical spectroscopic imaging of human tissue. The hybrid system (CWFD) can measure absolute optical properties from 660 nm to 980 nm and recover all tissue chromophore concentrations. The standalone FD module can be utilized to measure scattering at every measurement and recover deoxygenated and oxygenated hemoglobin concentrations. The CW module can operate concurrently with the FD module to also measure water and lipid. The high temporal resolution and large signal-to-noise ratio of the CWFD system may be used to explore tissue oximetry, vascular occlusion, and paced breathing models to measure and analyze tissue hemodynamics response to changes in blood flow. Continuous monitoring of vasculature response to various modified blood perfusion conditions can provide information about local tissue metabolism and physiological state (dysfunction).

2017020, Jul 27, 2017

Jan 20, 2017

15/411674

- Oakland CA, US
Goutham Ganesan - Irvine CA, US
Thomas O'Sullivan - Laguna HIlls CA, US
Shaista Malik - Orange CA, US
Bruce J. Tromberg - Irvine CA, US
Pietro Galassetti - Washington DC, US

A61B 5/00
A61B 5/145
A61B 5/1455

A quantitative, non-invasive optical spectroscopy technique for measuring dynamic changes in adipose tissue structure and metabolism in vivo. The technique requires multiple wavelengths of light in the near-infrared (650-1000 nm). Using these wavelengths of light, adipose tissue is illuminated and light that returns to a photodetector is analyzed. From the return signals, the absorption and reduced scattering coefficients (μand μ′) at each wavelength are calculated. The obtained pa and μ′ values allow for quantification of biomarkers and indices which allow for measurement of fat composition and metabolism. The concentration of oxy- and deoxy-hemoglobin, the fractional water and lipid content, and information about the size distribution of light scatterers in the adipose tissue are also determined. A detailed and quantitative understanding of fat composition and metabolism is thereby provided which describes the effectiveness of interventions to improve the health of a patient.

2016034, Dec 1, 2016

May 31, 2016

15/169426

- Oakland CA, US
Kyle Cutler - Irvine CA, US
Chris Van Wagenen - Irvine CA, US
Thomas O'Sullivan - Irvine CA, US
Gopi Meenakshisundaram - Irvine CA, US
Aditi Majumder - Irvine CA, US
Albert Cerussi - Irvine CA, US

The Regents of the University of California - Oakland CA

A61B 5/06
A61B 5/00

In accordance with various embodiments herein, disclosed herein is an apparatus comprising an imaging probe-based device operably linked to an automated tracking system. Furthermore, in various embodiments, the apparatus may be used to track the position and movement of a handheld imaging probe, including with respect to a subject's 3D surface profile. In one embodiment, a device may be used to track the position and movement of a handheld imaging probe with respect to a subject's 3D surface profile, while simultaneously acquiring optical data.