Inventors:
Richard M Weier - Lake Bluff IL
Paul W Collins - Deerfield IL
Michael A Stealey - Libertyville IL
Thomas E Barta - Evanston IL
Renee M Huff - Park Ridge IL
Assignee:
G D Searle Co. - Chicago IL
International Classification:
A01N 4350
US Classification:
514396, 514398, 548254, 5483117, 5483421, 5483335, 5483345, 5483371, 5483381, 5483411, 5483425, 5483255, 5483251, 5483451, 5483435, 5483431
Abstract:
A class of compounds is described for treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula wherein R is selected from lower alkyl, lower haloalkyl, lower hydroxyalkyl, lower alkoxyalkyl, lower alkenyloxyalkyl, mercapto, lower alkylcarbonyl, lower haloalkylcarbonyl, phenylcarbonyl, lower aralkylcarbonyl, lower aralkenyl, lower aryloxyalkyl, lower aralkyloxyalkyl, lower arylsulfonyl, lower aralkylsulfonyl, lower arylthioalkyl, lower heteroarylalkylthioalkyl, and heteroaryl selected from 2-thienyl, 2-furyl, 3-furyl, 2-pyridyl, 4-pyridyl and 2-benzofuryl; wherein R and R are independently selected from heteroaryl, cycloalkyl and aryl, wherein the heteroaryl, cycloalkyl and aryl radicals are substituted at a substitutable position with one or more radicals selected from hydrido, halo, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, aminosulfonyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower alkoxyalkyl, lower haloalkoxy, amino, lower alkylamino, phenylamino and nitro; and wherein R is selected from hydrido, lower alkyl and acyl; or a pharmaceutically-acceptable salt thereof.
