Wing Tom, 40New Hyde Park, NY

6498168, Dec 24, 2002

Jul 11, 2001

09/902849

Derek Lowe - Scotch Plains NJ
Wei Chang - Livingston NJ
Joseph Kozlowski - Princeton NJ
Joel G. Berger - Cedar Grove NJ
Robert McQuade - Scotch Plains NJ
Allen Barnett - Pine Brook NJ
Margaret Sherlock - Bloomfield NJ
Wing Tom - Cedar Grove NJ
Sundeep Dugar - Bridgewater NJ
John W Clader - Cranford NJ
Samuel Chackalamannil - East Brunswick NJ
Wang Yuguang - North Brunswick NJ
Stuart W. McCombie - Caldwell NJ
Jayaram R. Tagat - Westfield NJ
Susan F. Vice - Mountainside NJ
Wayne Vaccaro - Yardley PA
Michael J. Green - Skillman NJ
Margaret E. Browne - Bloomfield NJ
Theodros Asberom - West Orange NJ

Schering Corporation - Kenilworth NJ

C07D40102

514316, 546186, 546187, 546188, 546189

Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) wherein R, R , R , R , R , R , R , R , X, Y, and Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimers disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations of compounds of the above formula or other compounds capable of enhancing acetylcholine release with acetylcholinesterase inhibitors.

7105505, Sep 12, 2006

Apr 16, 2003

10/417391

Qingbei Zeng - Edison NJ, US
Robert G. Aslanian - Rockaway NJ, US
Michael Y. Berlin - Flemington NJ, US
Christopher W. Boyce - Flemington NJ, US
Jianhua Cao - Scotch Plains NJ, US
Joseph A. Kozlowski - Princeton NJ, US
Pietro Mangiaracina - Monsey NY, US
Kevin D. McCormick - Edison NJ, US
Mwangi W. Mutahi - Orange NJ, US
Stuart B. Rosenblum - West Orange NJ, US
Neng-Yang Shih - North Caldwell NJ, US
Daniel M. Solomon - Edison NJ, US
Wing C. Tom - Cedar Grove NJ, US

Schering Corporation - Kenilworth NJ

A61K 31/495

51421021, 544224, 544336, 546184, 546192, 546193, 546194

Disclosed are novel compounds of the formula.

7879880, Feb 1, 2011

Dec 19, 2006

11/641153

Daniel M. Solomon - Edison NJ, US
Robert G. Aslanian - Rockaway NJ, US
Michael Y. Berlin - Flemington NJ, US
Manuel de Lera Ruiz - Branchburg NJ, US
Kevin D. McCormick - Basking Ridge NJ, US
Mwangi W. Mutahi - Nyeri, KE
Wing C. Tom - Cedar Grove NJ, US

Schering Corporation - Kenilworth NJ

A61K 31/5377
A61K 31/496
A61K 31/4545
C07D 487/04
C07D 413/14
C07D 401/14
C07D 401/12

514318, 5142345, 51425301, 514303, 514316, 544354, 544360, 544130, 546118, 546187, 546193

Disclosed are compounds of the formula.

2002008, Jun 27, 2002

Sep 18, 2001

09/955383

Neng-Yang Shih - North Caldwell NJ, US
Robert Aslanian - Rockaway NJ, US
Daniel Solomon - Edison NJ, US
Stuart Rosenblum - West Orange NJ, US
Mwangi Mutahi - Fords NJ, US
Wing Tom - Cedar Grove NJ, US
Kevin Mc Cormick - Edison NJ, US
John Piwinski - Clinton Township NJ, US
Ronald Wolin - San Diego CA, US

A61K031/4545
A61K031/454
A61K031/4164
C 07D 4 1/14
C 07D 4 1/02

514/318000, 514/333000, 514/396000, 546/193000, 546/194000, 548/335100

The present invention discloses novel substituted imidazole compounds which have Hreceptor antagonist or dual histamine-Hand Hreceptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such imidazoles as well as methods of using them to treat allergy, nasal congestion, inflammatory and CNS-related diseases and others.

5023265, Jun 11, 1991

Jun 1, 1990

7/532304

Margaret H. Scherlock - Bloomfield NJ
Wing C. Tom - Cedar Grove NJ

Schering Corporation - Kenilworth NJ

A61K 31435
C07D47104

514300

Substituted 1H-pyrrolopyridine-3-carboxamides and their use in pharmaceutical compositions and in treating inflammation are disclosed.

5981520, Nov 9, 1999

Jun 17, 1998

9/099221

Neng-Yang Shih - North Caldwell NJ
David J. Blythin - North Caldwell NJ
Xiao Chen - Edison NJ
Wing C. Tom - Cedar Grove NJ
John J. Piwinski - Clinton Township NJ
Kevin D. McCormick - Edison NJ

Schering Corporation - Kenilworth NJ

A61K 31495
C07D40112
C07D40114
C07D41314

514212

The invention relates to compounds of the formula ##STR1## These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.

5883096, Mar 16, 1999

Feb 16, 1996

8/602403

Derek Lowe - Scotch Plains NJ
Wei Chang - Livingston NJ
Joseph Kozlowski - Princeton NJ
Joel G. Berger - Cedar Grove NJ
Robert McQuade - Scotch Plains NJ
Allen Barnett - Pine Brook NJ
Margaret Sherlock - Bloomfield NJ
Wing Tom - Cedar Grove NJ
Sundeep Dugar - Bridgewater NJ
John W. Clader - Cranford NJ
Samuel Chackalamannil - East Brunswick NJ
Wang Yuguang - North Brunswick NJ
Stuart W. McCombie - Caldwell NJ
Jayaram R. Tagat - Westfield NJ
Susan F. Vice - Mountainside NJ
Wayne Vaccaro - Yardley PA
Michael J. Green - Skillman NJ
Margaret E. Browne - Bloomfield NJ
Theodros Asberom - West Orange NJ

Schering Corporation - Kenilworth NJ

C07D29508
C07D30781
C07D33358
A61K 31495

514252

Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds of formula I ##STR1## wherein one of Y and Z is N and the other is N, CH, or C-alkyl; X is --O--, --SO. sub. 0-2 --, amino, substituted amino, --CO--, --CH. sub. 2 --, mono or di-substituted methylene, --CS--, --CONR. sup. 20 --, --NR. sup. 20 --SO. sub. 2 --, --NR. sup. 20 CO--, --SO. sub. 2 NR. sup. 20 --, --CH. dbd. CH--, --C. tbd. C-- or --NHC(O)NH--; R is optionally substituted phenyl, aryl or cycloalkyl, or other substituents as defined in the specification; R. sup. 1 and R. sup. 21 are H, CN or optionally substituted alkyl, or other substituents as defined in the specification; R. sup. 2 is optionally substituted cycloalkyl or piperidyl, or other substituents as defined in the specification; and R. sup. 3, R. sup. 4, R. sup. 5, R. sup. 20, R. sup. 27 and R. sup. 28 are as defined in the specification; are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease; pharmaceutical compositions and methods of preparation are also disclosed, as well as synergistic combinations of compounds of the above formula or other compounds capable of enhancing acetylcholine release with acetylcholinesterase inhibitors.

6037352, Mar 14, 2000

Nov 19, 1998

9/195742

Derek Lowe - Scotch Plains NJ
Wei Chang - Livingston NJ
Joseph Kozlowski - Princeton NJ
Joel G. Berger - Cedar Grove NJ
Robert McQuade - Scotch Plains NJ
Allen Barnett - Pine Brook NJ
Margaret Sherlock - Bloomfield NJ
Wing Tom - Cedar Grove NJ
Sundeep Dugar - Bridgewater NJ
John W Clader - Cranford NJ
Samuel Chackalamannil - East Brunswick NJ
Wang Yuguang - North Brunswick NJ
Stuart W. McCombie - Caldwell NJ
Jayaram R. Tagat - Westfield NJ
Susan F. Vice - Mountainside NJ
Wayne Vaccaro - Yardley PA
Michael J. Green - Skillman NJ
Margaret E. Browne - Bloomfield NJ
Theodros Asberom - West Orange NJ

Schering Corporation - Kenilworth NJ

A61K 31445
C07D21100
C07D21108

514316

Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) ##STR1## wherein R, R. sup. 1, R. sup. 2, R. sup. 3, R. sup. 4, R. sup. 21, R. sup. 27, R. sup. 28, X, Y, and Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations of compounds of the above formula or other compounds capable of enhancing acetylcholine release with acetylcholinesterase inhibitors.