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Troy M Mccracken, 43465 Mountain Ave, Berkeley Heights, NJ 07922

Known as:
Troy Michael Mccracken Troy M Mc Michael Mccracken
Related to:
Christine Piotrowski 81

Troy Mccracken Phones & Addresses

465 Mountain Ave, Berkeley Hts, NJ 07922   

Berkeley Heights, NJ   

Westfield, NJ   

Hoboken, NJ   

Jersey City, NJ   

Garwood, NJ   

Columbus, OH   

Wheeling, WV   

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Troy Mccracken resumes & CV records

Resumes

Troy Mccracken Photo 22

Troy Mccracken

Troy Mccracken Photo 23

Medicinal Chemist At Merck

Position:
Scientist at Merck
Location:
Greater New York City Area
Industry:
Pharmaceuticals
Work:
Merck - New Jersey since Jul 2012
Scientist Merck - New Jersey May 2011 - Jun 2012
Associate Scientist Merck - New Jersey Nov 2009 - Apr 2011
Assistant Scientist Schering-Plough - New Jersey Jul 2007 - Nov 2009
Assistant Scientist The Ohio State University Sep 2004 - Jun 2007
Graduate Teaching Assistant The Ohio State University Sep 2004 - Jun 2007
Graduate Research Assistant University of Illinois at Urbana Champaign Jun 2003 - May 2004
Undergraduate Research Assistant
Education:
The Ohio State University 2004 - 2007
M.S., Organic Chemistry University of Illinois at Urbana-Champaign 2000 - 2004
B.S., Chemistry, Economics
Skills:
Drug Discovery, Medicinal Chemistry, R&D, Organic Synthesis, Lead Optimization, Pharmaceutical Industry, Data Analysis, Chromatography

Publications & IP owners

Us Patents

Gamma Secretase Modulators

US Patent:
2011001, Jan 20, 2011
Filed:
Dec 4, 2008
Appl. No.:
12/746041
Inventors:
Xianhai Huang - Warren NJ, US
Anandan Palani - Bridgewater NJ, US
Jun Qin - Somerset NJ, US
Robert Aslanian - Rockaway NJ, US
Zhaoning Zhu - Plainsboro NJ, US
William Greenlee - Teaneck NJ, US
Hubert Josien - Jersey City NJ, US
Wei Zhou - Scotch Plains NJ, US
Xiaohong Zhou - Edison NJ, US
Chad E. Bennett - Metuchen NJ, US
Dmitri Pissarnitski - Scotch Plains NJ, US
Mihirbaran Mandal - Scotch Plains NJ, US
Pawan Dhondi - Elizabeth NJ, US
Troy McCracken - Hoboken NJ, US
Thomas Bara - Linden NJ, US
Zhiqiang Zhao - Scotch Plains NJ, US
Duane Burnett - Bernardsville NJ, US
John Clader - Cranford NJ, US
International Classification:
A61K 31/5383
C07D 471/04
A61K 31/437
C07D 487/04
A61K 31/519
A61K 31/5377
C07D 498/04
C07D 403/02
A61K 31/4178
A61P 25/28
US Classification:
5142305, 546119, 514303, 546115, 514302, 544263, 5142591, 544118, 5142332, 544105, 5483121, 514397
Abstract:
This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I) wherein Ris a fused bicyclic ring of the formula (II). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).

Gamma Secretase Modulators

US Patent:
2011025, Oct 20, 2011
Filed:
Nov 5, 2009
Appl. No.:
13/126056
Inventors:
Zhaoning Zhu - Plainsboro NJ, US
William J. Greenlee - Teaneck NJ, US
David James Cole - Springfield NJ, US
Dmitri A. Pissarnitski - Scotch Plains NJ, US
Gioconda V. Gallo - Summit NJ, US
Hongmei Li - Warren NJ, US
Hubert B. Josien - Jersey City NJ, US
Jun Qin - Edison NJ, US
Chad E. Knutson - Garwood NJ, US
Mihirbaran Mandal - Scotch Plains NJ, US
Monica L. Vicarel - North Brunswick NJ, US
Murali Rajagopalan - Edison NJ, US
Pawan Kumar Dhondi - Elizabeth NJ, US
Ruo Xu - Watchung NJ, US
Thomas A. Bara - Linden NJ, US
Xianhai Huang - Warren NJ, US
Xiaohong Zhu - Edison NJ, US
Zhiqiang Zhao - Scotch Plains NJ, US
John W. Clader - Milton VT, US
Anandan Palani - Bridgewater NJ, US
Theodros Asberom - West Orange NJ, US
Troy McCracken - Garwood NJ, US
Chad E. Bennett - Metuchen NJ, US
International Classification:
A61K 31/55
A61K 31/5383
A61K 31/5377
A61K 31/501
A61K 31/497
A61K 31/506
A61K 31/438
A61K 31/437
C07D 413/10
C07D 498/20
C07D 498/04
A61P 25/00
A61P 25/28
A61K 31/4245
A61K 31/5386
US Classification:
51421021, 51421402, 5142295, 5142302, 5142305, 5142332, 51425204, 51425304, 51425505, 514256, 514278, 514302, 514364, 540578, 544 70, 544101, 544105, 544127, 544238, 544333, 544362, 544405, 546 15, 546115, 548131
Abstract:
In its many embodiments, the present invention provides novel heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.

Gamma Secretase Modulators

US Patent:
2011029, Dec 1, 2011
Filed:
Nov 12, 2009
Appl. No.:
13/128493
Inventors:
Zhaoning Zhu - Plainsboro NJ, US
William J. - Greenlee NJ, US
Xianhai Huang - Warren NJ, US
Jun Qin - Somerset NJ, US
XIaoxiang Liu - River Vale NJ, US
Hongmei Li - Warren NJ, US
Wei Zhou - Kenliworth NJ, US
Anandan Palani - Bridgewater NJ, US
Xiaohong Zhu - Edison NJ, US
Monica L. Vicarel - Basking Ridge NJ, US
Mihirbaran Mandal - Scotch Plains NJ, US
Chad E. Bennett - Metuchen NJ, US
Troy Michael McCracken - Garwood NJ, US
Gioconda V. Gallo - Summit NJ, US
International Classification:
A61K 31/695
C07D 413/10
C07D 471/04
A61P 25/28
A61K 31/519
C07D 498/20
C07F 7/18
C07D 498/04
A61K 31/5395
US Classification:
514 63, 544 66, 544282, 5142292, 51425941
Abstract:
In its many embodiments, the present invention provides a novel class of heterocyclic compounds of Group A or Group, as defined herein, as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.

Gamma Secretase Modulators

US Patent:
2011030, Dec 15, 2011
Filed:
Nov 11, 2009
Appl. No.:
13/128316
Inventors:
Zhaoning Zhu - Plainsboro NJ, US
William J. Greenlee - Teaneck NJ, US
Hongmei Li - Warren NJ, US
Monica L. Vicarel - North Brunswick NJ, US
Jun Qin - Edison NJ, US
Pawan Kumar Dhondi - Elizabeth NJ, US
Xianhai Huang - Warren NJ, US
Anandan Palani - Bridgewater NJ, US
Xiaoxiang Liu - River Vale NJ, US
Hubert B. Josien - Jersey City NJ, US
Ruo Xu - Watchung NJ, US
David James Cole - Springfield NJ, US
Duane A. Burnett - Bernardsville NJ, US
Chad E. Bennett - Metuchen NJ, US
Troy McCracken - Garwood NJ, US
Malcolm MacCoss - Seabrook Island SC, US
International Classification:
A61K 31/553
C07D 498/10
C07D 498/04
A61P 25/28
C07D 413/14
C07D 498/14
A61K 31/5395
C07D 498/20
C07D 413/10
US Classification:
51421108, 544 66, 540545, 5142292
Abstract:
In its many embodiments, the present invention provides a novel class of heterocyclic compounds of the formula: as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more disease associated with the central nervous system using such compounds or pharmaceutical compostions.

Gamma Secretase Modulators

US Patent:
2012012, May 24, 2012
Filed:
Nov 5, 2009
Appl. No.:
13/126680
Inventors:
Zhaoning Zhu - Plainsboro NJ, US
William J. Greenlee - Teaneck NJ, US
Mihir Baran Mandal - Westfield NJ, US
Duane A. Burnett - Bernardsville NJ, US
Chad E. Bennett - Metuchen NJ, US
Troy McCracken - Garwood NJ, US
International Classification:
A61K 31/5386
A61K 31/53
A61K 31/55
C07D 498/04
A61K 31/5383
A61P 25/28
A61K 31/438
C07D 471/10
C07D 498/10
C07D 513/04
C07D 403/10
C07D 471/04
A61K 31/437
US Classification:
5142302, 544183, 514243, 514303, 540554, 544105, 5142305, 546119, 514278, 546 15, 544 70, 546114, 514301, 540501, 540543, 544182, 514242
Abstract:
In its many embodiments, the present invention provides a novel class of heterocyclic compounds of the formula: as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.

Fused Bicyclic Heterocycles Useful As Dipeptidyl Peptidase-Iv Inhibitors

US Patent:
2013032, Dec 5, 2013
Filed:
Mar 1, 2012
Appl. No.:
14/000641
Inventors:
Chad E. Bennett - Metuchen NJ, US
Duane A. Burnett - Bernardsville NJ, US
Hongmei Li - Warren NJ, US
Yonggang Chen - Westfield NJ, US
Troy McCracken - Garwood NJ, US
Monica Vicarel - Ravenna OH, US
International Classification:
C07D 487/04
A61K 45/06
A61K 31/522
A61K 31/519
C07D 473/28
US Classification:
51426322, 544280, 5142651, 544276
Abstract:
The present invention is directed to novel bicyclic heterocycles of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

Heteroaryl-Pyrimidinone Compounds As Pde2 Inhibitors

US Patent:
2018028, Oct 4, 2018
Filed:
May 2, 2016
Appl. No.:
15/571192
Inventors:
- Rahway NJ, US
Jonathan E. Wilson - NJ, US
Troy McCracken - Berkeley Heights NJ, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
A61K 31/513
A61P 25/06
A61P 25/16
A61P 25/18
A61P 25/22
A61P 25/28
Abstract:
The present invention is directed to substituted pyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

Pyrazolyl Pyrimidinone Compounds As Pde2 Inhibitors

US Patent:
2018005, Mar 1, 2018
Filed:
Mar 21, 2016
Appl. No.:
15/559284
Inventors:
- Rahway NJ, US
Jonathan E. Wilson - South Orange NJ, US
Meng Yang - Westfield NJ, US
Dann Parker - Cranford NJ, US
Zack Zhiqiang Guo - Morganville NJ, US
Alejandro Crespo - Westfield NJ, US
Deping Wang - Furlong PA, US
Troy McCracken - Berkeley Heights NJ, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C07D 403/04
C07D 405/14
C07D 401/14
Abstract:
The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

Possible Relatives

Cynthia J Mccracken  David L Mccracken  Dean M Mccracken  Deanna J Mccracken  Deborah L Mccracken  Daniel Mccracken  Aaron Mccracken  Troy J Johnson  Troy A Standefer  Troy W Stanford 

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