Tyler Greer resumes & CV records
Resumes
Tyler Greer
Tyler Greer
Tyler J Greer, 38Elmsford, NY
Tyler Greer Phones & Addresses
Elmsford, NY
11 Abbey Ln UNIT 1303, Danbury, CT 06810 989-4241190
Middleton, WI
Ann Arbor, MI
Gladwin, MI
White Plains, NY
Mentions for Tyler J Greer
Publications & IP owners
Us Patents
Novel Isobaric Tandem Mass Tags For Quantitative Proteomics And Peptidomics
US Patent:
2013007, Mar 28, 2013
Filed:
Sep 14, 2012
Appl. No.:
13/619164
Inventors:
Lingjun Li - Madison WI, US
Feng Xiang - Midland MI, US
Tyler Greer - Middleton WI, US
Dustin Frost - Madison WI, US
Zhidan Liang - Madison WI, US
Feng Xiang - Midland MI, US
Tyler Greer - Middleton WI, US
Dustin Frost - Madison WI, US
Zhidan Liang - Madison WI, US
International Classification:
C07D 207/46
US Classification:
436 86, 548542
Abstract:
Compositions and methods of tagging peptides and other molecules using novel isobaric tandem mass tagging reagents, including novel N,N-dimethylated amino acid 8-plex and 16-plex isobaric tandem mass tagging reagents. The tagging reagents comprise: a) a reporter group having at least one atom that is optionally isotopically labeled; b) a balancing group, also having at least one atom that is optionally isotopically labeled, and c) an amine reactive group. The tagging reagents disclosed herein serve as attractive alternatives for isobaric tag for relative and absolute quantitation (iTRAQ) and tandem mass tags (TMTs) due to their synthetic simplicity, labeling efficiency and improved fragmentation efficiency.
Electron Transfer Dissociation And Mass Spectrometry For Improved Protein Sequencing Of Monoclonal Antibodies
US Patent:
2022032, Oct 13, 2022
Filed:
Feb 25, 2022
Appl. No.:
17/681156
Inventors:
- Tarrytown NY, US
Milos Cejkov - Ridgewood NJ, US
Tyler Greer - Elmsford NY, US
Reid O'Brien Johnson - Hartsdale NY, US
Milos Cejkov - Ridgewood NJ, US
Tyler Greer - Elmsford NY, US
Reid O'Brien Johnson - Hartsdale NY, US
International Classification:
G01N 33/68
G01N 30/72
G01N 30/72
Abstract:
The present disclosure provides an improved method for accurately measuring the amino acid sequence of a therapeutic protein, in particular, an antibody, to insure the homogeneity of the protein such that it is suitable for administering to a human subject for treating a disease or disorder. The methods employ analytical physical chemistry techniques, in particular, a guided electron-transfer dissociation (ETD) and mass spectrometry (MS) approach for robust sequence coverage of the molecule with high accuracy and speed of use.
Method To Prevent Sample Preparation-Induced Disulfide Scrambling In Non-Reduced Peptide Mapping
US Patent:
2023009, Mar 23, 2023
Filed:
Sep 15, 2022
Appl. No.:
17/945398
Inventors:
- Tarrytown NY, US
Tyler Greer - Elmsford NY, US
Xiaojing Zheng - Gaithersburg MD, US
Tyler Greer - Elmsford NY, US
Xiaojing Zheng - Gaithersburg MD, US
International Classification:
G01N 33/68
C07K 1/16
C07K 1/16
Abstract:
The present invention generally pertains to methods of preventing disulfide scrambling in non-reducing liquid chromatography-mass spectrometry analysis of a protein of interest. In particular, the present invention pertains to the addition of cystamine to a non-reducing liquid chromatography-mass spectrometry analysis of an antibody to prevent disulfide scrambling.
Methods For Characterizing Host-Cell Proteins
US Patent:
2021010, Apr 15, 2021
Filed:
Oct 15, 2020
Appl. No.:
17/071399
Inventors:
- Tarrytown NY, US
Reid O'Brien Johnson - Hartsdale NY, US
Tyler Greer - Elmsford NY, US
Reid O'Brien Johnson - Hartsdale NY, US
Tyler Greer - Elmsford NY, US
International Classification:
G01N 33/68
G01N 33/94
G01N 33/94
Abstract:
Methods for characterizing host-cell proteins in a sample matrix are provided.
Novel Isobaric Tandem Mass Tags For Quantitative Proteomics And Peptidomics
US Patent:
2016035, Dec 8, 2016
Filed:
Jun 14, 2016
Appl. No.:
15/182329
Inventors:
- Madison WI, US
Feng XIANG - Midland MI, US
Tyler GREER - Middleton WI, US
Dustin FROST - Madison WI, US
Zhidan LIANG - Madison WI, US
Feng XIANG - Midland MI, US
Tyler GREER - Middleton WI, US
Dustin FROST - Madison WI, US
Zhidan LIANG - Madison WI, US
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
G01N 33/68
C07D 207/46
C07D 207/46
Abstract:
Compositions and methods of tagging peptides and other molecules using novel isobaric tandem mass tagging reagents, including novel N, N-dimethylated amino acid 8-plex and 16-plex isobaric tandem mass tagging reagents. The tagging reagents comprise: a) a reporter group having at least one atom that is optionally isotopically labeled; b) a balancing group, also having at least one atom that is optionally isotopically labeled, and c) an amine reactive group. The tagging reagents disclosed herein serve as attractive alternatives for isobaric tag for relative and absolute quantitation (iTRAQ) and tandem mass tags (TMTs) due to their synthetic simplicity, labeling efficiency and improved fragmentation efficiency.
NOTICE: You may not use BackgroundCheck or the information it provides to make decisions about employment, credit, housing or any other purpose that would require Fair Credit Reporting Act (FCRA) compliance. BackgroundCheck is not a Consumer Reporting Agency (CRA) as defined by the FCRA and does not provide consumer reports.