Vanessa M King, 5739 Parkside Ave, Miller Place, NY 11764

2014001, Jan 9, 2014

Jun 27, 2013

13/928430

Tommaso Mansi - Westfield NJ, US
Wei Keat Lim - Jersey City NJ, US
Vanessa King - Princeton NJ, US
Andreas Kremer - Wien, AT
Bogdan Georgescu - Plainsboro NJ, US
Xudong Zheng - Plainsboro NJ, US
Ali Kamen - Skillman NJ, US
Andreas Keller - Puttlingen, DE
Cord Friedrich Staehler - Hirschberg an der Bergstrasse, DE
Emil Wirsz - Furth, DE
Dorin Comaniciu - Princeton Junction NJ, US

SIEMENS CORPORATION - Iselin NJ
SIEMENS AG OSTERREICH - Wien
SIEMENS AKTIENGESELLSCHAFT - Munich

G06F 19/00

703 11

A system operating in a plurality of modes to provide an integrated analysis of molecular data, imaging data, and clinical data associated with a patient includes a multi-scale model, a molecular model, and a linking component. The multi-scale model is configured to generate one or more estimated multi-scale parameters based on the clinical data and the imaging data when the system operates in a first mode, and generate a model of organ functionality based on one or more inferred multi-scale parameters when the system operates in a second mode. The molecular model is configured to generate one or more first molecular findings based on a molecular network analysis of the molecular data, wherein the molecular model is constrained by the estimated parameters when the system operates in the first mode. The linking component, which is operably coupled to the multi-scale model and the molecular model, is configured to transfer the estimated multi-scale parameters from the multi-scale model to the molecular model when the system operates in the first mode, and generate, using a machine learning process, the inferred multi-scale parameters based on the molecular findings when the system operates in the second mode.