Resumes & CV records
Resumes
Vincent P Stanton, 94474 Belmont St, Watertown, MA 02472
Vincent Stanton Phones & Addresses
474 Belmont St, Watertown, MA 02472 617-9268016
Brookline, MA
2149 Massachusetts Ave, Cambridge, MA 02140 617-6619517
41 Whidah Rd, North Chatham, MA 02650 508-9454363
Newton, MA
Social networks
Vincent P Stanton
Linkedin
Mentions for Vincent P Stanton
Publications & IP owners
Us Patents
Identification Of Genetic Components Of Drug Response
US Patent:
2002001, Jan 31, 2002
Filed:
Jan 22, 2001
Appl. No.:
09/767892
Inventors:
Vincent Stanton - Belmont MA, US
International Classification:
C12Q001/68
C12Q001/00
C12Q001/00
US Classification:
435/006000, 435/004000
Abstract:
The present invention is concerned generally with the field of identifying an appropriate treatment regimen for a disease based upon genotype in mammals, particularly in humans. It is further concerned with the genetic basis of inter-patient variation in response to therapy, including drug therapy. Specifically, this invention describes the identification of gene sequence variances useful in the field of therapeutics for optimizing efficacy and safety of drug therapy. These variances may be useful during the drug development process and in guiding the optimal use of already approved compounds. DNA sequence variances in candidate genes (i.e., genes that may plausibly affect the action of a drug) are tested in clinical trials, leading to the establishment of diagnostic tests useful for improving the development of new pharmaceutical products and/or the more effective use of existing pharmaceutical products. Methods for identifying genetic variances and determining their utility in the selection of optimal therapy for specific patients are also described. In general, the invention relates to methods for identifying patient population subsets that respond to drug therapy with either therapeutic benefit or side effects (i.e., symptomatology prompting concern about safety or other unwanted signs or symptoms).
Gene Sequence Variances In Genes Related To Folate Metabolism Having Utility In Determining The Treatment Of Disease
US Patent:
2002003, Apr 4, 2002
Filed:
Dec 7, 2000
Appl. No.:
09/733651
Inventors:
Vincent Stanton - Belmont MA, US
International Classification:
A61K031/00
C12Q001/68
C12Q001/68
US Classification:
514/001000, 435/006000
Abstract:
The present disclosure describes the use of genetic variance information for folate transport or metabolism genes or pyrimidine transport or metabolism genes in the selection of effective methods of treatment of a disease or condition. The variance information is indicative of the expected response of a patient to a method of treatment. Methods of determining relevant variance information and additional methods of using such variance information are also described.
Probes For Variance Detection
US Patent:
2002008, Jun 27, 2002
Filed:
Jan 7, 2002
Appl. No.:
10/040721
Inventors:
Vincent Stanton - Belmont MA, US
International Classification:
C12Q001/68
US Classification:
435/006000, 204/461000
Abstract:
Disclosed are methods and reagents for detecting nucleotide mismatches (for example, due to sequence variances) in a nucleic acid sample involving the use of a nucleic acid probe derived from a hemizygous cell. Methods for determining the haplotype of a nucleic acid sample are also disclosed. Also disclosed are methods for producing the probe and kits containing the probe.
Inhibitors Of Alternative Alleles Of Genes Encoding Products That Mediate Cell Response To Environmental Changes
US Patent:
2002012, Sep 12, 2002
Filed:
Feb 14, 2001
Appl. No.:
09/782837
Inventors:
David Housman - Newton MA, US
Fred Ledley - Needham MA, US
Vincent Stanton - Belmont MA, US
Fred Ledley - Needham MA, US
Vincent Stanton - Belmont MA, US
Assignee:
Variagenics, Inc., a Delaware corporation
International Classification:
C07H021/02
C07H021/04
C12N005/06
C12N005/16
C07H021/04
C12N005/06
C12N005/16
US Classification:
435/344000, 536/023100
Abstract:
Disclosed are methods for the treatment of proliferative disorders using compounds and/or environmental conditions which result in a difference in sensitivity of targeted and non-targeted cells. Certain of the methods involve the identification and use of allele-specific inhibitors of conditionally essential genes.
Genotyping By Mass Spectrometric Analysis Of Allelic Fragments
US Patent:
2002015, Oct 17, 2002
Filed:
Mar 26, 2002
Appl. No.:
10/107751
Inventors:
Vincent Stanton - Belmont MA, US
Jeffrey Olson - Chelmsford MA, US
Jia Wolfe - Winchester MA, US
Martin Zillmann - Shrewsbury MA, US
Jeffrey Olson - Chelmsford MA, US
Jia Wolfe - Winchester MA, US
Martin Zillmann - Shrewsbury MA, US
Assignee:
Variagenics, Inc.
International Classification:
C12Q001/68
C12P019/34
C12P019/34
US Classification:
435/006000, 435/091200
Abstract:
The present invention relates to a method for genotyping a diploid organism by cleaving segments of two alleles such that 7-20 nucleotide fragments that contain a suspected polymorphic locus are produced and comparing the masses of those fragments.
Restriction Enzyme Genotyping
US Patent:
2003007, Apr 17, 2003
Filed:
Apr 4, 2002
Appl. No.:
10/116420
Inventors:
Jeffrey Olson - Chelmsford MA, US
Martin Zillmann - Shrewsbury MA, US
Vincent Stanton - Belmont MA, US
Martin Zillmann - Shrewsbury MA, US
Vincent Stanton - Belmont MA, US
International Classification:
C12Q001/68
C12P019/34
C12P019/34
US Classification:
435/006000, 435/091200
Abstract:
Methods for determing genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information.
Methods For Targeting Rna Molecules
US Patent:
2003007, Apr 17, 2003
Filed:
Sep 26, 2002
Appl. No.:
10/256987
Inventors:
Ling Shen - Marlboro MA, US
Gregory Verdine - Lexington MA, US
James Basilion - Brookline MA, US
Vincent Stanton - Belmont MA, US
Gregory Verdine - Lexington MA, US
James Basilion - Brookline MA, US
Vincent Stanton - Belmont MA, US
Assignee:
Variagenics, Inc., a Delaware corporation
International Classification:
C12Q001/68
US Classification:
435/006000
Abstract:
Described are methods for identifying targets in RNA molecules based on differences in RNA secondary structure related to sequence variances between different allelic forms. Also described are methods for identifying or developing small molecules which can be used to modulate a target RNA by creation of protein-small-molecule-RNA complexes, as well as compositions which include such small molecules and methods of using those small molecules and compositions.
Methods For Genetic Analysis Of Dna To Detect Sequence Variances
US Patent:
2003008, May 1, 2003
Filed:
May 23, 2001
Appl. No.:
09/863733
Inventors:
Vincent Stanton - Belmont MA, US
International Classification:
C12Q001/68
C12P019/34
C12P019/34
US Classification:
435/006000, 435/091200
Abstract:
Methods for determing genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information.
NOTICE: You may not use BackgroundCheck or the information it provides to make decisions about employment, credit, housing or any other purpose that would require Fair Credit Reporting Act (FCRA) compliance. BackgroundCheck is not a Consumer Reporting Agency (CRA) as defined by the FCRA and does not provide consumer reports.