Virginia Irvin Gordon, 85143 W 53Rd St, Long Beach, CA 90805

6489132, Dec 3, 2002

Sep 2, 1999

09/388974

Virginia C. Gordon - Huntington Beach CA
John T. Sorensen - Costa Mesa CA
Soheila Mirhashemi - Laguna Niguel CA
Michael Mittelstein - Laguna Niguel CA
John F. Elias - Buena Park CA

Safety Associates, Inc. - Tustin CA

G01N 3353

435 792, 435 71, 435179, 435180, 436175, 436177, 436178, 436518, 436527, 436530, 436824, 436825, 422 56, 422 58, 422 60, 422 681, 422 82, 422102, 422147, 422188, 422190, 422211, 422213, 422216, 422236, 422239, 422240, 422101, 210200, 210201, 210203, 210238, 210252, 210253, 210255, 210263, 210290, 210295, 210301, 210322, 210314, 2103231, 210348, 21050029, 210600, 210634, 210649, 210767, 210800, 210806, 210908

Methods and apparatus for qualitatively or quantitatively determining one or more analytes in matrices such as foods, biological fluids, etc. An embodiment for determination of a single analyte comprises a sample receiving vessel, a first membrane and a reagent-containing well. The prepared sample passes through the first membrane whereby extraneous matter is removed, and a filtrate enters the reagent-containing well to provide a filtrate-reagent admixture from which the analyte may be determined. An embodiment for determination for multiple analytes includes one or more additional membranes in series with the first membrane, each such additional membrane being operative to capture one or more analytes. Each of the additional analytes may then be eluted from the membrane upon which it has been captured, into a separate reagent-containing well to provide eluant-reagent admixture from which each desired analyte may be determined. Formulations for preparation additives are also included.

6852289, Feb 8, 2005

Mar 26, 2001

09/817446

Virginia C. Gordon - Huntington Beach CA, US
Barbara J. Peasley - Brea CA, US
John F. Elias - Buena Park CA, US
John T. Sorensen - Costa Mesa CA, US
Michael Mittelstein - Laguna Niguel CA, US
Soheila Mirhashemi - Laguna Niguel CA, US

Saftest, Inc. - Tempe AZ

B01L011/00
B01D024/00
C12M003/00

422101, 4352871, 4352884, 4352885, 210335

Methods and apparatus for qualitatively or quantitatively determining one or more analytes in matrices such as foods, biological fluids, etc. An embodiment for determination of a single analyte comprises a sample receiving vessel, a first membrane and a reagent-containing well. The prepared sample passes through the first membrane whereby extraneous matter is removed, and a filtrate enters the reagent-containing well to provide a filtrate-reagent admixture from which the analyte may be determined. An embodiment for determination for multiple analytes includes one or more additional membranes in series with the first membrane, each such additional membrane being operative to capture one or more analytes. Each of the additional analytes may then be eluted from the membrane upon which it has been captured, into a separate reagent-containing well to provide eluant-reagent admixture from which each desired analyte may be determined. Formulations for preparation additives are also included.

2003014, Aug 7, 2003

Dec 20, 2002

10/325505

Virginia Gordon - Huntington Beach CA, US

Saftest, Inc. - Phoenix AZ

C12Q001/68
C12M001/34
G01N033/558

435/006000, 435/287200, 436/514000

Methods and systems for determining the presence of one or more analytes in various types of matricies, such as foods, oils, biological fluids, etc. Membranes are used to remove extraneous matter (e.g., solid particles) and/or to bind specific interferents or analytes. Specific assays are provided for determining citric acid, total fat (or % fat), free fatty acids, protein content and specific nucleic acid content indicative of the presence of DNA and/or RNA of certain microbes (e.g., pathogens) or genetically altered substances (e.g., genetically engineered grain).

2004019, Oct 7, 2004

Feb 27, 2004

10/789864

John Sorensen - Costa Mesa CA, US
Michael Mittelstein - Laguna Niguel CA, US
Soheila Mirhashemi - Laguna Niguel CA, US
Virginia Gordon - Huntington Beach CA, US
Bennett Root - Huntington Beach CA, US
Barbara Peasley - Brea CA, US
John Elias - Buena Park CA, US

Safety Associates, Inc.

B01L011/00
G01N033/03

422/101000, 436/111000, 436/060000, 436/119000

Methods and apparatus for qualitatively or quantitatively determining one or more analytes in matrices such as foods, biological fluids, etc. An embodiment for determination of a single analyte comprises a sample receiving vessel, a first membrane and a reagent-containing well. The prepared sample passes through the first membrane whereby extraneous matter is removed, and a filtrate enters the reagent-containing well to provide a filtrate-reagent admixture from which the analyte may be determined. An embodiment for determination for multiple analytes includes one or more additional membranes in series with the first membrane, each such additional membrane being operative to capture one or more analytes. Each of the additional analytes may then be eluted from the membrane upon which it has been captured, into a separate reagent-containing well to provide eluant-reagent admixture from which each desired analyte may be determined. Formulations for preparation additives are also included. Additionally, there's provided an embodiment of above-described invention for determination of an analyte which is present in a matrix at low (e.g., sub-detectable) levels, wherein the filter of the apparatus is utilized to capture and concentrate the analyte, to provide a filtrate-reagent admixture wherein the analyte is present at detectable concentration.

5958714, Sep 28, 1999

Oct 2, 1996

8/723636

Virginia C. Gordon - Huntington Beach CA
John T. Sorensen - Costa Mesa CA
Soheila Mirhashemi - Laguna Niguel CA
Michael Mittelstein - Laguna Niguel CA
John F. Elias - Buena Park CA

Safety Associates, Inc. - Tustin CA

G01N 3353

435 792

Methods and apparatus for qualitatively or quantitatively determining one or more analytes in matrices such as foods, biological fluids, etc. An embodiment for determination of a single analyte comprises a sample receiving vessel, a first membrane and a reagent-containing well. The prepared sample passes through the first membrane whereby extraneous matter is removed, and a filtrate enters the reagent-containing well to provide a filtrate-reagent admixture from which the analyte may be determined. An embodiment for determination for multiple analytes includes one or more additional membranes in series with the first membrane, each such additional membrane being operative to capture one or more analytes. Each of the additional analytes may then be eluted from the membrane upon which it has been captured, into a separate reagent-containing well to provide eluant-reagent admixture from which each desired analyte may be determined. Formulations for preparation additives are also included.

5411888, May 2, 1995

Jul 27, 1993

8/098735

Virginia C. Gordon - Huntington Beach CA
Soheila Mirhashemi - Laguna Niguel CA
Rosalind W. Wei - Costa Mesa CA

Invitro International - Irvine CA

G01N 1300
G01N 2129

436 5

Methods for determining the corrosivity of a substance to human skin or membrane are disclosed. In one approach, corrosivity is evaluated by measuring the time required for the test substance to transit a biobarrier that mimics human skin or membranes or the time required to cause a component of such biobarrier to break down and transit the membrane. The invention also envisions alternative approaches which involve series of layers of dyes and corrosive-resistant materials coated onto microspheres or test strips. Use of these methods provides a rapid determination of the corrosivity of test materials.

4613574, Sep 23, 1986

May 4, 1984

6/607483

Hyman C. Bergman - Los Angeles CA
James F. Godfrey - Venice CA
Virginia C. Gordon - Pacific Palisades CA

Preventive Diagnostics Corporation - Carson CA

G01N 2175
G01N 3350

436 2

A reagent and method for in vitro determination of the eye irritating properties of individual compounds and/or mixtures is disclosed. The material to be assessed is combined with the reagent which provides a response, for example, the production of a precipitate, which is proportional to the deleterious response elicited by the material in the human eye.

5612222, Mar 18, 1997

Jan 11, 1995

8/371276

Virginia C. Gordon - Huntington Beach CA
Soheila Mirhashemi - Laguna Niguel CA
Rosalind W. Wei - Costa Mesa CA

In Vitro International - Irvine CA

G01N 1300
G01N 2129

436 5

Methods and a device for determining the corrosivity of a substance to human skin or membrane are disclosed. In one approach, corrosivity is evaluated by measuring the time required for the test substance to transit a biobarrier that mimics human skin or membranes or the time required to cause a component of such biobarrier to break down and transit the membrane. The invention also envisions alternative approaches which involve series of layers of dyes and corrosive-resistant materials coated onto microspheres or test strips. Use of these methods provides a rapid determination of the corrosivity of test materials.