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Walter Scott Willett DeceasedNorthville, MI

Walter Willett Phones & Addresses

Northville, MI   

1246 Walton Blvd, Pontiac, MI 48340    248-3733161   

Bloomfield Hills, MI   

Doylestown, PA   

Troy, MI   

Detroit, MI   

3820 Comley Cir, Doylestown, PA 18902   

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Position: Service Occupations

Education

Degree: High school graduate or higher

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Walter Willett

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Walter Willett

Dr. Walter Willett, MD, DrPH., (born in 1945 in Hart, Michigan) is an American physician and nutrition researcher. Currently, Dr. Willett is the Fredrick ...

Us Patents

Glycopegylated Erythropoietin Formulations

US Patent:
7842661, Nov 30, 2010
Filed:
May 25, 2006
Appl. No.:
11/440839
Inventors:
Shawn DeFrees - North Wales PA, US
Robert J. Bayer - San Diego CA, US
David A. Zopf - Wayne PA, US
Jichao Kang - Pennington NJ, US
Walter Scott Willett - Doylestown PA, US
Assignee:
Novo Nordisk A/S - Bagsvaerd
International Classification:
C07K 14/00
C07K 14/505
A61K 38/00
A61K 38/16
US Classification:
514 2, 514 8, 514 12, 530303, 530324, 530351, 53038823
Abstract:
The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

Manufacturing Process For The Production Of Peptides Grown In Insect Cell Lines

US Patent:
2006024, Nov 2, 2006
Filed:
Mar 30, 2006
Appl. No.:
11/396215
Inventors:
Yun Kang - Livingston NJ, US
Walter Willett - Doylestown PA, US
Thomas Klimek - Philadelphia PA, US
Basil Campbell - Gaithersburg MD, US
Paul Cino - Jamison PA, US
Bradley Thomas - Quakertown PA, US
John Bermel - Telford PA, US
Chun-Chiang Chen - Gaithersburg MD, US
Assignee:
Neose Technologies,Inc. - Horsham PA
International Classification:
C12P 21/06
C12N 9/24
C12N 5/06
C07K 14/53
C07K 14/51
US Classification:
435069100, 435320100, 435348000, 435200000, 530351000, 530414000, 530399000
Abstract:
The present invention provides a manufacturing method for the production of peptides that are grown in insect cell lines. The peptides are grown in insect cell cultures that are infected with baculovirus particles in a culture supplemented with a lipid mixture. The peptides are then isolated from the insect cell culture using a method that employs a tangential flow filtration cascade. The isolated peptides are glycopeptides having an insect specific glycosylation pattern. The glycopeptides may then be conjugated to a modifying group via linkage through a glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase.

Cyclodextrin Affinity Purification

US Patent:
2007010, May 10, 2007
Filed:
May 5, 2004
Appl. No.:
10/555123
Inventors:
Joseph Villafranca - New Hope PA, US
David Hakes - Willow Grove PA, US
Karl Johnson - Hatboro PA, US
Walter Willett - Doylestown PA, US
Chester Meyers - Medford NJ, US
International Classification:
C12P 21/06
C12P 19/62
C12P 19/28
C12P 19/04
C12N 9/10
US Classification:
435069100, 435085000, 435101000, 435193000, 435076000
Abstract:
A method of immobilizing a molecular species that include a starch-binding domain is provided. There also is provided a material upon which the molecular species is immobilized, and a material that is capable of immobilizing the species The method includes binding the species to a solid support, e.g., membranes, chromatographic supports and the like. The immobilized species is optionally purified by the method of the invention. Alternatively, the immobilized species is use in another method, such as in a synthesis as a synthetic reagent, or to purify another species that has an affinity for the immobilized species. Exemplary immobilized molecular species include bioactive agents, and biomolecules.

One Pot Desialylation And Glycopegylation Of Therapeutic Peptides

US Patent:
2007010, May 10, 2007
Filed:
Oct 13, 2006
Appl. No.:
11/580669
Inventors:
Shawn DeFrees - North Wales PA, US
David Zopf - Wayne PA, US
Susann Taudte - Pennsburg PA, US
Walter Willett - Doylestown PA, US
Robert Bayer - San Diego CA, US
Matthew Kalo - San Diego CA, US
Assignee:
Neose Technologies, Inc. - Horsham PA
International Classification:
A61K 38/36
C12P 21/06
US Classification:
514008000, 435068100
Abstract:
The present invention provides conjugates between peptides and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.

Glycopegylated Granulocyte Colony Stimulating Factor

US Patent:
2009020, Aug 13, 2009
Filed:
Jan 10, 2006
Appl. No.:
11/794560
Inventors:
Shawn Defrees - North Wales PA, US
Henrik Clausen - Holte, DK
David A. Zopf - Wayne PA, US
Caryn Bowe - Doylestown PA, US
Susann Taudte - Pennsburg PA, US
Michael Felo - Merrimack NH, US
Walter S. Willett - Doylestown PA, US
International Classification:
A61K 38/16
C07K 14/00
C12P 21/02
US Classification:
514 8, 530395, 435 681
Abstract:
The present invention provides conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.

Glycopegylated Factor Vii And Factor Viia

US Patent:
2009030, Dec 10, 2009
Filed:
Aug 21, 2006
Appl. No.:
12/064012
Inventors:
Shawn DeFrees - North Wales PA, US
David A. Zopf - Wayne PA, US
Susann Taudte - Pennsburg PA, US
Walter S. Willett - Doylestown PA, US
Mattew Kalo - San Francisco CA, US
Robert J. Bayer - San Diego CA, US
Assignee:
Novo Nordisk A/S - Bagsvaerd
International Classification:
A61K 38/36
C12P 21/02
A61P 7/04
US Classification:
514 12, 435 681
Abstract:
The present invention provides conjugates between Factor VII or Factor VIIa peptides and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.

One Pot Desialylation And Glycopegylation Of Therapeutic Peptides

US Patent:
2010033, Dec 30, 2010
Filed:
May 20, 2010
Appl. No.:
12/784323
Inventors:
Shawn DeFrees - North Wales PA, US
David A. Zopf - Wayne PA, US
Susann Taudte - Pennsburg PA, US
Walter Scott Willett - Doylestown PA, US
Robert J. Bayer - San Diego CA, US
Matthew Kalo - San Francisco CA, US
Assignee:
NOVO NORDISK A/S - Bagsvaerd
International Classification:
C12N 9/96
US Classification:
435188
Abstract:
The present invention provides conjugates between peptides and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.

Glycopegylated Erythropoietin Formulations

US Patent:
2011000, Jan 6, 2011
Filed:
May 25, 2006
Appl. No.:
11/914104
Inventors:
Shawn DeFrees - North Wales PA, US
Robert J. Bayer - San Diego CA, US
David A. Zopf - Wayne PA, US
Jichao Kang - Pennington NJ, US
Walter Scott Willett - Doylestown PA, US
Assignee:
Novo Nordisk A/S - Bagsvaerd
International Classification:
C07K 14/505
A61K 38/18
US Classification:
514 77, 530397
Abstract:
The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

Isbn (Books And Publications)

Eat, Drink, And Be Healthy: The Harvard Medical School Guide To Healthy Eating

Author:
Walter C. Willett
ISBN #:
0743266420

Nutritional Epidemiology

Author:
Walter Willett
ISBN #:
0195045017

Nutritional Epidemiology

Author:
Walter Willett
ISBN #:
0195122976

Eat, Drink, And Be Healthy : The Harvard Medical School Guide To Healthy Eating

Author:
Walter Willett
ISBN #:
0684863375

Eat, Drink, And Be Healthy : The Harvard Medical School Guide To Healthy Eating

Author:
Walter Willett
ISBN #:
0743223225

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