William S O'Shaughnessy, 48Lincoln Center, MA

2010015, Jun 17, 2010

Dec 7, 2009

12/632686

Jun Li - Brookline MA, US
Trevor Squier - Peabody MA, US
Zheng Zhang - Cambridge MA, US
Chad Huval - Somerville MA, US
William Shannan O'Shaughnessy - Boston MA, US
Michael Hencke - Cambridge MA, US
Michael Bouchard - Wyomissing PA, US
Christopher R. Loose - Cambridge MA, US

A61L 29/14
C08F 290/14
B32B 5/02
B32B 15/08
B32B 27/04
B32B 27/36
B32B 9/04
B32B 27/38
C08F 112/08
C08F 283/04
C08F 283/06
C08F 283/12
C08F 220/56
C08F 210/00
C07H 1/00
C07H 23/00
C08J 3/28
B05D 3/06

604523, 525 50, 442123, 428446, 428457, 428461, 428458, 428412, 428447, 428413, 428418, 5253333, 525453, 5253303, 5253294, 525418, 525474, 525477, 525523, 5253262, 5253337, 5361231, 536121, 522149, 427553

Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted from the substrate, or optionally from an undercoating layer on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.

2007025, Nov 1, 2007

Feb 15, 2007

11/675500

Christopher Loose - Cambridge MA, US
William O'Shaughnessy - Boston MA, US
LinO Ferreira - Cambridge MA, US
Andreas Zumbuehl - Bern, CH
Robert Langer - Newton MA, US
Gregory Stephanopoulos - Winchester MA, US

A61K 9/70
A61F 2/00
A61K 38/00

424423000, 424443000, 514002000

Antimicrobial peptides enable an alternate approach to developing antimicrobial coatings due to their targeting of the membranes of the bacteria. High specific activity is achieved by orienting the peptides so that the antimicrobial ends of the peptides maximally contact the bacteria. In one embodiment, one end of the peptide is covalently attached directly to the substrate. In another embodiment, the peptides are immobilized on the substrate using a coupling agent or tether. Non-covalent methods include coating the peptide onto the substrate or physiochemically immobilizing the peptides on the substrate using highly specific interactions, such as the biotin/avidin or streptavidin system. The compositions are substantially non-leaching, antifouling, and non-hemolytic. The immobilized peptides retain sufficient flexibility and mobility to interact with and de endocytosed by the bacteria, viruses, and/or fungi upon exposure. Immobilizing the peptides to the substrate reduces concerns regarding toxicity of the peptides and the development of antimicrobial resistance, while presenting substantially all of the peptide at the site of action at the surface of the substrate.

2016007, Mar 17, 2016

Apr 29, 2014

14/787544

- Cambridge MA, US
William Shannan O'Shaughnessy - Cambridge MA, US
Seth Johnson - Watertown MA, US
Karen K. Gleason - Cambridge MA, US

B08B 17/06
C23C 16/50
B05D 3/06
C23C 16/02

Liquid-impregnated textured coatings containing one or more materials on a variety of surfaces are described herein. The coatings can be prepared by chemical vapor deposition techniques or other techniques known in the art. The texture can be random, fractal, or patterned. The texture can be pores, cavities, and/or micro- and/or nanoscale features/structures. The capillary forces arising from the nano- or microscopic texture of the coating stabilizes the liquid within the textured features and at the surface of the coating resulting in non-wetting properties for a variety of surfaces. They coatings may be formed in a single layer or as multiple layers. In order to maximize ease of deposition and processing, the coating may be formed of graded composition to optimize both bulk and surface properties without the need for multiple coatings.