William C Parsons, 44400 Nineteen North Dr, Pittsburgh, PA 15237

2008028, Nov 13, 2008

Mar 25, 2005

10/594367

Jun Liang - Palo Alto CA, US
Prasun K. Chakravarty - Edison NJ, US
Deborah E. Pan - Cranford NJ, US
William H. Parsons - Belle Mead NJ, US
Pengcheng P. Shao - Fanwood NJ, US
Feng Yee - Scotch Plains NJ, US
Bishan Zhou - Hoboken NJ, US

A61K 31/4965
C07D 241/24

51421018, 544406, 51425506

Biaryl substituted pyrazinone compounds represented by Formula I, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, urinary incontinence, itchiness, allergic dermatitis, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

D346562, May 3, 1994

Apr 23, 1992

7/873290

William H. Parsons - Birmingham AL
Lloyd W. Hillman - Huntsville AL

D10111