William Wayne Seitz, 7114707 Evergreen Ridge Way, Houston, TX 77062

7048951, May 23, 2006

May 24, 2000

10/296110

William A. Seitz - Dickinson TX, US
Robert E. Garfield - Friendswood TX, US
Alexandru T. Balaban - Columbia MD, US
Randall J. Stewart - Galveston TX, US

Nioxx, LLC - Dickinson TX

A61K 33/00

424718, 514474, 514458, 514578

A simple, biocompatible system and procedure for generating nitric oxide (NO) is described. A mixture of powdered sodium nitrite, ascorbic acid, and maleic acid (or another organic acid of adequate strength) immediately generates nitric oxide (NO) on treatment with water. To slow down the NO generation, one may prepare an ointment from a nonaqueous medium (petrolatum, Vaseline™) and the three powdered ingredients, which on being applied topically on the skin will release NO as water permeates through this medium; alternatively, one may convert the aqueous sodium nitrite solution into a gel with hydroxyethylcellulose (or other gel-forming compound) and combine this gel with another gel obtained from aqueous ascorbic and maleic acids with hydroxyethylcellulose for topical application (on intact skin, burns intra-cavity, burns, intra-cavity, etc. ). The two gels may be admixed immediately before use (possibly from a single container with separate chambers and dual nozzle, via pushing or squeezing the two gels through the nozzle), or may be applied in sandwich-like fashion (possibly as a transdermal patch) for further slowing down the delivery of NO.

7456197, Nov 25, 2008

Jul 1, 2004

10/882667

Alexandru T. Balaban - Galveston TX, US
William A. Seitz - Dickinson TX, US
Marc A. C. Ilies - Philadelphia PA, US
Edward Bradbridge Thompson - Galveston TX, US
Robert E. Garfield - Galveston TX, US
Betty H. Johnson - Beaumont TX, US
Aaron L. Miller - Galveston TX, US
Melissa J. Wentz - Pearland TX, US

The Texas A&M University System - College Station TX

C07D 401/02
C12N 15/85

514318, 546255, 5462681, 546347, 435455, 514317, 514358

Pyridinium cationic lipids useful as non-viral gene delivery agents are disclosed. The agents are prepared by reaction of pyrylium salts with primary amines. Also disclosed are methods of trasfectind cells using the pyridinium cationic lipids as gene transfer agents.

2009013, May 28, 2009

Nov 24, 2008

12/276949

Alexandru T. Balaban - Galveston TX, US
William A. Seitz - Dickinson TX, US
Marc A. C. Ilies - Philadelphia PA, US
Edward Bradbridge Thompson - Galveston TX, US
Robert E. Garfield - Galveston TX, US
Betty H. Johnson - Beaumont TX, US
Aaron L. Miller - Galveston TX, US
Melissa J. Wentz - Pearland TX, US

C12N 15/87
C07F 9/58

435455, 546 22

Pyridinium cationic lipids useful as non-viral gene delivery agents are disclosed. The agents are prepared by reaction of pyrylium salts with primary amines. Also disclosed are methods of trasfectind cells using the pyridinium cationic lipids as gene transfer agents.

2013033, Dec 12, 2013

Nov 29, 2012

13/688511

William A. Seitz - Dickinson TX, US
Kenneth A. Smith - Houston TX, US

NIOXX LLC - Dickinson TX

A61M 35/00

422225, 422129, 422236

A simple, biocompatible two-component system and procedure for generating nitric oxide (NO) is described. One component comprises sodium nitrite or other nitrite source, and the other component comprises a reductant, an acid and a base although in certain embodiments the reductant and acid functions are provided by the same component. When these two components are mixed directly at a local site of administration or immediately prior to application and the mixture generates nitric oxide (NO) for topical application. The activated system is therapeutic for treatment of multiple conditions, including promotion of healing, disinfection, promotion of hair growth, and treatment of male and female sexual dysfunction.

5698738, Dec 16, 1997

May 15, 1995

8/440970

Robert E. Garfield - Friendswood TX
Alexandru T. Balaban - Galveston TX
William A. Seitz - Dickinson TX
Douglas J. Klein - Galveston TX
Melanie Lesko - Friendswood TX

Board of Regents, The University of Texas System
The Texas A&M University System

A61K 31135
C07C24306

564112

Nitric oxide has proved to mediate many important physiological processes. The nitric oxide donors of the present invention have a NONOate anion linked to an ortho-substituted aryl, a heteroaromatic substituent, asteroid, or a catecholamine. Preferred ortho substituents are alkoxy, halo, and alkyl. The cation of the salt is an alkali metal, an alkaline-earth metal, an ammonium or substituted ammonium group. Nitric oxide donors provided herein are more stable than that of nitrogen-bonded NONOates described previously. The by product left after release of NO, and the nitric oxide donors themselves, are very probably less carcinogenic than the corresponding nitrogen-bonded NONOates.

6103275, Aug 15, 2000

Jun 10, 1998

9/095174

William A. Seitz - Dickinson TX
Robert E. Garfield - Friendswood TX
Alexandru T. Balaban - Columbia MD
Randall J. Stewart - Galveston TX

Nitric Oxide Solutions - Dickinson TX

A61K 3300

424718

A simple, biocompatible system and procedure for generating nitric oxide (NO) is described. A mixture of powdered sodium nitrite, ascorbic acid, and maleic acid (or another organic acid of adequate strength) immediately generates nitric oxide (NO) on treatment with water. To slow down the NO generation, one may prepare an ointment from a nonaqueous medium (petrolatum, vaseline) and the three powdered ingredients, which on being applied topically on the skin will release NO as water permeates through this medium; alternatively, one may convert the aqueous sodium nitrite solution into a gel with hydroxyethylcellulose (or other gel-forming compound) and combine this gel with another gel obtained from aqueous ascorbic and maleic acids with hydroxyethylcellulose for topical application (on intact skin, burns, intra-cavity, etc. ). The two gels may be admixed immediately before use (possibly from a single container with separate chambers and dual nozzle, via pushing or squeezing the two gels through the nozzle), or may be applied in sandwich-like fashion (possibly as a transdermal patch) for further slowing down the delivery of NO.