Xia Xu resumes & CV records
Resumes
Xia Xu
Xia Xu
Xia Xu
Xia Xu
Location:
United States
Xia Hongwei L Xu, 611933 Moran Dr, Frederick, MD 21702
Xia Xu Phones & Addresses
1933 Moran Dr, Frederick, MD 21702 301-6625938
1944 Crossing Stone Ct, Frederick, MD 21702 301-6625938
Germantown, MD
1885 Wilson Ave, Saint Paul, MN 55119 651-5780163
Ames, IA
Work
Position:
Professional/Technical
Education
Degree:
Graduate or professional degree
Mentions for Xia Hongwei L Xu
Publications & IP owners
Us Patents
Methods For Separation And Detection Of Ketosteroids And Other Carbonyl-Containing Compounds
US Patent:
7807472, Oct 5, 2010
Filed:
Apr 15, 2003
Appl. No.:
10/511409
Inventors:
Xia Xu - Frederick MD, US
Regina G. Ziegler - Bethesda MD, US
David J. Waterhouse - Frederick MD, US
Joseph E. Saavedra - Thurmont MD, US
Larry K. Keefer - Bethesda MD, US
Regina G. Ziegler - Bethesda MD, US
David J. Waterhouse - Frederick MD, US
Joseph E. Saavedra - Thurmont MD, US
Larry K. Keefer - Bethesda MD, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
G01N 33/00
G01N 1/00
G01N 1/00
US Classification:
436 87, 436173, 436817, 4352871
Abstract:
Methods for enhancing detection by mass spectroscopy (MS) and/or chromatographic separability of carbonyl-containing compounds such as steroids are disclosed. Reaction of a carbonyl compound with a sulfonhydrazide compound provides a sulfonhydrazone with enhanced ionization efficiency during the electrospray ionization process. In a particularly disclosed embodiment, derivatization of catechol estrogens with p-toluenesulfonhydrazide enhances both detection by atmospheric pressure ionization-MS (API-MS), such as electron spray ionization-MS (ESI-MS) and separation by liquid chromatography (such as HPLC) under reverse phase conditions. In yet other embodiments, the sulfonhydrazone is further reacted with a sulfonyl halide under alkaline conditions to derivatize hydroxyl groups in the compound. Prior formation of the sulfonhydrazide derivative protects the carbonyl bond of the compound during subsequent alkaline reaction with the sulfonyl halide.
Analysis Of Large Numbers Of Estrogens And Other Steroids And Applications Thereof
US Patent:
2007000, Jan 4, 2007
Filed:
Jun 7, 2006
Appl. No.:
11/449484
Inventors:
Xia Xu - Frederick MD, US
Timothy Veenstra - Jefferson MD, US
Larry Keefer - Bethesda MD, US
Regina Ziegler - Bethesda MD, US
Timothy Veenstra - Jefferson MD, US
Larry Keefer - Bethesda MD, US
Regina Ziegler - Bethesda MD, US
International Classification:
G01N 33/00
US Classification:
436087000
Abstract:
Mass-spectrometry based methods of analyzing estrogens and other steroids from biological samples are disclosed herein. Further disclosed are methods of detecting the presence of illegal steroids in a mammal. Methods of detecting a disease state or condition or elevated risk of a disease state or condition in a mammal are also disclosed. Also disclosed are kits for use in a method for detecting and/or quantifying one or more steroids in a sample by mass spectrometry.
Analysis Of Steroid Hormones In Thin Tissue Sections
US Patent:
2009021, Aug 27, 2009
Filed:
Nov 17, 2008
Appl. No.:
12/272015
Inventors:
Timothy D. Veenstra - Jefferson MD, US
Xia Xu - Frederick MD, US
Josip Blonder - Frederick MD, US
Regina G. Ziegler - Bethesda MD, US
Xia Xu - Frederick MD, US
Josip Blonder - Frederick MD, US
Regina G. Ziegler - Bethesda MD, US
International Classification:
G01N 1/30
US Classification:
435 4052
Abstract:
Mass-spectrometry based methods of analyzing estrogens and other steroids from biological tissue sections samples are disclosed herein. Methods of detecting a disease state or condition or elevated risk of a disease state or condition in a mammal from tissue sections are also disclosed.
Possible Relatives
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