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Hong Yi Xue, 7614 Brookdale Rd, E Brunswick, NJ 08816

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Austin, TX   

Santa Clara, CA   

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East Brunswick, NJ   

North Miami, FL   

946 Tamarack Ln APT 2, Sunnyvale, CA 94086   

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Us Patents

Contact Lenses Made With Hema-Compatible Polysiloxane Macromers

US Patent:
2017000, Jan 12, 2017
Filed:
Feb 25, 2015
Appl. No.:
15/115271
Inventors:
- St. Michael, BB
Charlie Chen - San Ramon CA, US
Yuan Xu - Fremont CA, US
Yuwen Liu - Dublin CA, US
Ying Zheng - Pleasanton CA, US
Paul Richardson - San Ramon CA, US
Hong Xue - Pleasanton CA, US
Assignee:
CooperVision International Holding Company, LP - St. Michael
International Classification:
C08F 220/20
C08G 77/46
B29C 35/02
C08G 77/20
Abstract:
HEMA-compatible siloxane monomers are described that can be used to manufacture contact lenses that combine the attributes of HEMA-based contact lenses with the high oxygen permeability of silicone hydrogel lenses. Optically clear silicone hydrogel contact lens can be manufactured that comprise a polymeric lens body that is the reaction product of a polymerizable composition comprising: a) at least 25 wt. % of at least one hydroxyalkyl methacrylate; and b) at least 20 wt. % of at least one HEMA-compatible polysiloxane.

Crosslinked Zwitterionic Hydrogels

US Patent:
2017000, Jan 12, 2017
Filed:
Jul 15, 2016
Appl. No.:
15/211278
Inventors:
- Seattle WA, US
Hong Xue - Pleasanton CA, US
Wei Yang - Seattle WA, US
Louisa R. Carr - Schenectady NY, US
Assignee:
University of Washington through its Center for Commercialization - Seattle WA
International Classification:
C08L 33/14
C08J 3/075
C12Q 1/54
Abstract:
Zwitterionic crosslinking agents, crosslinked zwitterionic hydrogels prepared from copolymerization of zwitterionic monomers with the zwitterionic crosslinking agent, methods for making crosslinked zwitterionic hydrogels, and devices that include and methods that use the crosslinked zwitterionic hydrogels.

Primary Amine-Containing Silicone Hydrogel Contact Lenses And Related Compositions And Methods

US Patent:
2016005, Feb 25, 2016
Filed:
Apr 30, 2014
Appl. No.:
14/781041
Inventors:
- St Michael, BB
Hong Xue - Pleasanton CA, US
Assignee:
CooperVision International Holding Company., LP - St. Michael
International Classification:
G02B 1/04
B65B 25/00
B29C 35/00
Abstract:
Miscible polymerizable compositions comprising at least one primary amine-containing methacrylate monomer, or at least one primary amine-containing methacrylamide monomer, in addition to 20-80 wt. % siloxane monomer, 20-80 wt. % hydrophilic monomer, cross-linking agent, and polymerization initiator, are described. These polymerizable compositions can be used to form silicone hydrogel contact lenses, and in methods of manufacturing silicone hydrogel contact lenses.

Crosslinked Zwitterionic Hydrogels

US Patent:
2015003, Feb 5, 2015
Filed:
Aug 12, 2014
Appl. No.:
14/457801
Inventors:
- Seattle WA, US
Hong Xue - Pleasanton CA, US
Wei Yang - Seattle WA, US
Louisa R. Carr - Schenectady NY, US
Assignee:
University of Washington through its Center for Commercialization - Seattle WA
International Classification:
C08L 33/10
US Classification:
428480, 524766
Abstract:
Zwitterionic crosslinking agents, crosslinked zwitterionic hydrogels prepared from copolymerization of zwitterionic monomers with the zwitterionic crosslinking agent, methods for making crosslinked zwitterionic hydrogels, and devices that include and methods that use the crosslinked zwitterionic hydrogels.

Production And Purification Of Carboxylic Betaine Zwitterionic Monomers

US Patent:
2014027, Sep 18, 2014
Filed:
Mar 14, 2014
Appl. No.:
14/212407
Inventors:
- Seattle WA, US
Hong Xue - Pleasanton CA, US
Yingquan Song - Sammamish WA, US
Assignee:
Zwitter Technology, LLC - Seattle WA
International Classification:
C07C 227/40
US Classification:
560218
Abstract:
A method is provided for the production and purification of carboxylic betaine-based zwitterionic vinyl monomers, such as (meth)acrylic or (meth)acrylamide monomer containing a betaine-type group of the formula:wherein A is an ester, amide, benzyl, pyridinyl, or imidazolyl; R is hydrogen or methyl; and n is an integer from 0 to 10.The method involves the reaction of acrylic acid with aminoalkyl (meth)acrylate or N-amino-alkyl (meth)acrylamide having a basic tertiary nitrogen atom in the presence of a free radical inhibitor, this reaction leads to a betaine:acid complex that can be either separated from the reaction media into pure betaine:acid complex powder or further purified into pure monomer powder by passing the reaction mixture through a base resin followed by precipitation in a nonsolvent or direct precipitation in a nonsolvent containing an organic base.

Reactive Dyes For Contact Lenses

US Patent:
2014020, Jul 17, 2014
Filed:
Jul 17, 2012
Appl. No.:
14/131915
Inventors:
Yuan Xu - Fremont CA, US
Charlie Chen - San Ramon CA, US
Charles A. Francis - Union City CA, US
Shane Mao - San Ramon CA, US
Hong Xue - Pleasanton CA, US
Xining Zhang - Union City CA, US
International Classification:
C09B 1/34
G02B 1/04
C09B 1/16
US Classification:
523107, 560221, 528 26
Abstract:
A method for preparing a polymerizable monomer-dye compound is provided in which a monomer, a reactive dye, and base are combined under substantially anhydrous reaction conditions to form the polymerizable monomer-dye compound, wherein the monomer comprises a pendant reactive group that covalently links to the reactive dye to form the monomer-dye compound.

Silicone Hydrogel Contact Lenses For Sustained Release Of Beneficial Polymers

US Patent:
2014017, Jun 26, 2014
Filed:
Dec 18, 2013
Appl. No.:
14/109979
Inventors:
- St. Michael, BB
Victoria Rogers - Pleasanton CA, US
Junhao Ge - Pleasanton CA, US
Hong Xue - Pleasanton CA, US
Yuwen Liu - Pleasanton CA, US
Arthur Back - Pleasanton CA, US
Yun Zhang - Pleasanton CA, US
Ying Ye - Irvine CA, US
Peter Zhu - Los Altos CA, US
Assignee:
CooperVision International Holding Company, LP - St. Michael
International Classification:
A45C 11/00
B65B 55/02
US Classification:
206205, 53428, 53425
Abstract:
Silicone hydrogel contact lenses comprising an ionic component sustain release of beneficial cationic polymers.

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