Inventors:
- Boston MA, US
Tinghu Zhang - Brookline MA, US
Yao Liu - Brookline MA, US
Mengyang Fan - Allston MA, US
Yang Gao - Boston MA, US
Assignee:
Dana-Farber Cancer Institute, Inc. - Boston MA
International Classification:
C07D 205/04
C07D 207/14
C07D 211/56
C07D 223/12
C07D 495/04
C07D 211/42
C07D 209/12
C07C 233/44
C07D 401/12
C07D 401/06
C07D 471/04
C07D 487/10
C07D 487/04
C07D 403/04
C07D 413/04
C07D 405/14
A61K 45/06
Abstract:
Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, compositions, and mixtures thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing diseases (e.g., proliferative diseases (e.g., cancers, such as carcinoma, sarcoma, lung cancer, thyroid cancer, skin cancer, ovarian cancer, colorectal cancer, prostate cancer, pancreatic cancer, esophageal cancer, liver cancer, breast cancer)) in a subject. Provided are methods of inhibiting a TEAD transcription factors (e.g., TEAD1, TEAD2, TEAD3, TEAD4) in a subject.