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Yao Ma, 51Richmond, RI

Yao Ma Phones & Addresses

Richmond, RI   

31 Beacon St, Westwood, MA 02090    781-3263525   

31 Beacon St, Westwood, MA 02090    781-3263525   

205 Wood St, Lexington, MA 02421    781-8623306    781-8626866   

450 Normandy Dr, Norwood, MA 02062   

27 Old Carriage Rd, West Warwick, RI 02893    401-8283593   

Groton, CT   

Shrewsbury, MA   

Worcester, MA   

Social networks

Yao Ma

Linkedin

Work

Company: Merck Nov 2009 to 2012 Address: Merck Position: Medicinal chemist, group leader ii --- merck

Education

Degree: Doctor of Philosophy (Ph.D.) School / High School: Worcester Polytechnic Institute 1995 to 2000 Specialities: Organic Chemistry

Skills

Drug Discovery • Medicinal Chemistry • Drug Design • Organic Synthesis • Lead Change • High Throughput Screening

Industries

Pharmaceuticals

Mentions for Yao Ma

Resumes

Resumes

Yao Ma Photo 1

Medicinal Chemist At Merck

Position:
Medicinal Chemist, Group Leader II --- Merck at Merck
Location:
Greater Boston Area
Industry:
Pharmaceuticals
Work:
Merck - Merck since Nov 2009
Medicinal Chemist, Group Leader II --- Merck
Schering-Plough Research Institute 2005 - 2009
Group Leader I, II --- Schering-Plough
NeoGenesis Pharmaceuticals 2000 - 2004
Senior Scientist, Principal Scientist --- NeoGenesis
Education:
Worcester Polytechnic Institute 1995 - 2000
Doctor of Philosophy (Ph.D.), Organic Chemistry
Institute of Chemistry, Academia Sinica 1988 - 1991
Master's degree, Organic Chemistry
Beijing Normal University 1984 - 1988
Bachelor's degree, Chemistry
Skills:
Drug Discovery, Medicinal Chemistry, Drug Design, Organic Synthesis, Lead Change, High Throughput Screening

Business Records

Name / TitleCompany / ClassificationPhones & Addresses
Yao Ma
Director
TOP CHINESE INC 1185 Washington St SUITE 2, West Newton, MA 02465
205 Wood St Lexington Ma 02421 Usa<Br/>205 Wood St, Lexington, MA 02421

Publications

Us Patents

Hdm2 Polypeptides

US Patent:
7705127, Apr 27, 2010
Filed:
Oct 10, 2008
Appl. No.:
12/249314
Inventors:
Thomas E. Hesson - Burlington NJ,
Hung V. Le - Rockaway NJ,
Yao Ma - Lexington MA,
Vincent S. Madison - Mountain Lakes NJ,
Anthony F. Mannarino - Melrose MA,
Paul Reichert - Montville NJ,
Corey O. Strickland - Martinsville NJ,
Shahriar Shane Taremi - Upper Montclair NJ,
Yaolin Wang - Edison NJ,
Rumin Zhang - Edison NJ,
Jose Duca - Cranford NJ,
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07K 14/00
US Classification:
530350
Abstract:
The present invention relates to HDM2 polypeptides and mutants thereof which are complexed with various compounds, e. g. , HDM2 inhibitors.

Substituted Piperidines That Increase P53 Activity And The Uses Thereof

US Patent:
7884107, Feb 8, 2011
Filed:
Jun 27, 2007
Appl. No.:
11/769030
Inventors:
Yao Ma - Westwood MA,
Brian Robert Lahue - Millbury MA,
Yaolin Wang - Edison NJ,
Stephane L. Bogen - Somerset NJ,
Matthew Ernst Voss - Nassau NY,
Latha G. Nair - Edison NJ,
Yuan Tian - Newton MA,
Ronald J. Doll - Convent Station NJ,
Zhuyan Guo - Scotch Plains NJ,
Corey O. Strickland - Martinsville NJ,
Rumin Zhang - Edison NJ,
Mark A. McCoy - Acton MA,
Weidong Pan - Somerset NJ,
Elise M. Siegel - Jersey City NJ,
Craig R. Gibeau - Arlington MA,
Assignee:
Merck - Kenilworth NJ
International Classification:
A61K 31/54
C07D 413/00
C07D 403/00
C07D 405/00
US Classification:
51425313, 544130, 544364, 5142255
Abstract:
In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.

Hdm2 Polypeptides

US Patent:
7888474, Feb 15, 2011
Filed:
Mar 12, 2010
Appl. No.:
12/723184
Inventors:
Thomas E. Hesson - Burlington NJ,
Hung V. Le - Rockaway NJ,
Yao Ma - Lexington MA,
Vincent S. Madison - Ukiah CA,
Anthony F. Mannarino - Melrose MA,
Paul Reichert - Montville NJ,
Corey O. Strickland - Martinsville NJ,
Shahriar Shane Taremi - Cambridge MA,
Yaolin Wang - Short Hills NJ,
Rumin Zhang - Edison NJ,
Jose Duca - Cranford NJ,
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07K 14/00
US Classification:
530350
Abstract:
The present invention relates to HDM2 polypeptides and mutants thereof which are complexed with various compounds, e. g. , HDM2 inhibitors.

Method Of Using Substituted Piperidines That Increase P53 Activity

US Patent:
2008000, Jan 3, 2008
Filed:
Jun 27, 2007
Appl. No.:
11/769003
Inventors:
Yaolin Wang - Edison NJ,
Rumin Zhang - Edison NJ,
Yao Ma - Westwood MA,
Brian Robert Lahue - Millbury MA,
Gerald W. Shipps - Stoneham MA,
International Classification:
A61K 31/496
A61K 31/4545
A61K 31/454
US Classification:
51425309, 51425313, 514318, 51425312, 514316, 514317
Abstract:
The present invention discloses a method of using compounds, which have HDM2 protein antagonist activity, to treat or prevent cancer, other diseases caused by abnormal cell proliferation, diseases associated with HDM2, or diseases caused by inadequate P53 activity.

Substituted Piperidines That Increase P53 Activity And The Uses Thereof

US Patent:
2012020, Aug 16, 2012
Filed:
Oct 5, 2010
Appl. No.:
13/501685
Inventors:
Stephane L. Bogen - Somerset NJ,
Yao Ma - Lexington MA,
Yaolin Wang - Short Hills NJ,
Brian Robert Lahue - Millbury MA,
Latha G. Nair - Edison NJ,
Manami Shizuka - Lexington MA,
Matthew Ernst Voss - Nassau NY,
Weidong Pan - Somerset NJ,
Yuan Tian - Newton MA,
Bheemashankar A. Kulkarni - Bangalore,
Craig R. Gibeau - Natick MA,
Yuan Liu - Belmont MA,
Giovanna Scapin - Staten Island NY,
Diane Rindgen - North Plainfield NJ,
Ronald J. Doll - Convent Station NJ,
Timothy J. Guzi - Sudbury MA,
Danny J. Hicklin - Montclair NJ,
Amin Nomeir - Milford NJ,
Malcolm MacCoss - Brookline MA,
International Classification:
A61K 31/4545
A61P 35/02
A61P 35/00
C07D 409/14
C07D 401/14
US Classification:
514316, 546187
Abstract:
The present invention provides a compound of Formula (1) as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.

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