Yong Qiu Zhang, 37Cape Girardeau, MO

2006016, Jul 27, 2006

Dec 26, 2003

10/540817

Yong Zhang - Jamaica NY, US
Fei Ye - Beijing, CN
Fan Li - Beijing, CN

A61K 36/539
A61K 31/737
A61K 31/7008

424741000, 514062000, 514054000

This invention described various formula composite of for various diseases and conditions. The formula takes the advantage of our recent discovery of can inhibit cyclooxygenase-2 (COX-2) activity and expression, resulting in decrease of prostaglandin synthesis. COX-2 is involved in many biological processes, such as inflammation, pain, carcinogenesis, etc. Combination of with lycopene can be used for cancer prevention, especially smoking induced. Combination of with glucosamine and chondroitin can be used for arthritis. Finally, this invention disclosed various method to prepare this formula and composition.

2021032, Oct 21, 2021

Jul 23, 2019

17/250448

- Tokyo, JP
Chad J. SWANSON - Woodcliff Lake NJ, US
Yong ZHANG - Woodcliff Lake NJ, US
Shobha DHADDA - Woodcliff Lake NJ, US
Jinping WANG - Woodcliff Lake NJ, US
Lynn KRAMER - Woodcliff Lake NJ, US

C07K 16/18
A61K 31/542
A61P 25/28

Provided herein are methods of reducing clinical decline in a subject having early Alzheimer's disease, methods of converting an amyloid positive subject having early Alzheimer's disease to amyloid negative, methods of reducing brain amyloid level in a subject, and methods of preventing Alzheimer's disease, the methods comprising administering a composition comprising a therapeutically effective amount of at least one anti-Aβ protofibril antibody. In some embodiments, the subject is ApoE4-positive. In some embodiments, the at least one anti-Aβ protofibril antibody is BAN2401.

2017017, Jun 22, 2017

Dec 20, 2016

15/384429

Raphaelle Berger - New York NY, US
Yi-Heng Chen - Whippany NJ, US
Guoqing Li - Belle Mead NJ, US
Joie Garfunkle - Kriens, CH
Shouwu Miao - Edison NJ, US
Subharekha Raghavan - Teaneck NJ, US
Cameron J. Smith - Montgomery Village MD, US
John Stelmach - Westfield NJ, US
Alan Whitehead - Scotch Plains NJ, US
Rui Zhang - Plainsboro NJ, US
Yong Zhang - West Windsor NJ, US
Jianmin Fu - Beijing, CN
Gang Ji - Beijing, CN
Falong Jiang - Beijing, CN

C07D 487/04
A61K 31/519
C07D 519/00
A61K 45/06

The invention provides compounds of the Formula (I)or a pharmaceutically acceptable salts thereof, wherein X, Y, Z, R, R, R, R, and the subscripts m, p, and q are as described herein. The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate (“cGMP”), and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose.

2016030, Oct 20, 2016

Dec 5, 2014

15/103140

Xiaoqing HAN - Rahway NJ, US
Alan WHITEHEAD - Rahway NJ, US
Subharekha RAGHAVAN - Rahway NJ, US
Jonathan GROEPER - Indianapolis IN, US
Jian GUO - Zhengzhou, Henan, CN
Yong ZHANG - Rahway NJ, US
- Rahway NJ, US

Merck Sharp & Dohme Corp. - Rahway NJ

C07D 519/00
A61K 31/519
A61K 45/06

A compound of Formula I or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I, or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula I or a pharmaceutically acceptable salt thereof.

2016030, Oct 20, 2016

Dec 5, 2014

15/103148

Xiaoqing HAN - Rayway NJ, US
Alan WHITEHEAD - Rahway NJ, US
Subharekha RAGHAVAN - Rahway NJ, US
Timothy A. CERNAK - Boston MA, US
Spencer DREHER - Rahway NJ, US
Jonathan GROEPER - Indianapolis IN, US
Jian GUO - Henan, CN
Yong ZHANG - Rahway NJ, US
- Rahway NJ, US

Merck Sharp & Dohme Corp. - Rahway NJ

C07D 519/00
A61K 45/06
A61K 31/519

A compound of Formula I or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I, or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula I or a pharmaceutically acceptable salt thereof.

2014037, Dec 25, 2014

Jan 30, 2013

14/375145

- Basel, CH
Matthew Squires - Basel, CH
Catherne Reddick - Orange NJ, US
Yong Zhang - East Hanover NJ, US

NOVARTIS AG - Basel

A61K 31/496
A61K 31/565

514171

A pharmaceutical combination comprising (a) a RTK inhibitor selected from the group consisting of compounds of Formula I or a tautomer thereof, compounds of Formula II or a tautomer thereof, compounds of Formula III or a tautomer thereof, a pharmaceutically acceptable salt of the compound, a pharmaceutically acceptable salt of the tautomer, or a mixture thereof; and (b) one or more anti-estrogen compounds, or a pharmaceutically acceptable salt thereof; such as tamoxifen, toremifene, fulvestrant, raloxifene or raloxifene hydrochloride; the uses of such combination in the treatment or prevention of proliferative diseases: and methods of treating a subject suffering from a proliferative disease; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.