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Yuhong Zhang, 631290 N Pt Dr UNIT L, Stevens Point, WI 54481

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Us Patents

Method Of Screening Test Substances For Treating Or Preventing A Disease Mediated By Plasma Cells

US Patent:
2003022, Dec 4, 2003
Filed:
Apr 11, 2003
Appl. No.:
10/413538
Inventors:
David Ron - New York NY, US
Marcella Calfon - New York NY, US
Heather Harding - Brooklyn NY, US
Yuhong Zhang - Elmhurst NY, US
International Classification:
A61K031/00
C12Q001/68
G01N033/567
US Classification:
435/006000, 435/007210, 514/001000
Abstract:
The present invention relates to a method of screening a compound for potential effectiveness in treating or preventing a mammalian disease mediated by plasma cells or a mammalian disease caused by virus infection of mammalian cells. Compounds are tested for their ability to inhibit IRE1-mediated processing of untranslatable XBP-1 mRNA into translatable XBP-1 mRNA. Drugs that are useful in treating or preventing a mammalian disease mediated by plasma cells and a method for detecting XBP-1 activity in living cells are also described.

Method Of Screening Test Substances For Treating Or Preventing A Disease Mediated By Plasma Cells

US Patent:
2010010, Apr 29, 2010
Filed:
Dec 30, 2009
Appl. No.:
12/649849
Inventors:
David Ron - New York NY, US
Marcella Calfon - New York NY, US
Heather Harding - Brooklyn NY, US
Yuhong Zhang - Elmhurst NY, US
Assignee:
NEW YORK UNIVERSITY - New York NY
International Classification:
C12Q 1/68
C07H 21/02
US Classification:
435 6, 536 231
Abstract:
The present invention relates to a method of screening a compound for potential effectiveness in treating or preventing a mammalian disease mediated by plasma cells or a mammalian disease caused by virus infection of mammalian cells. Compounds are tested for their ability to inhibit IRE1-mediated processing of untranslatable XBP-1 mRNA into translatable XBP-1 mRNA. Drugs that are useful in treating or preventing a mammalian disease mediated by plasma cells and a method for detecting XBP-1 activity in living cells are also described.

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