Zhenyu Zhu resumes & CV records
Resumes
Zhenyu Zhu
Zhenyu Zhu
Zhenyu C Zhu, 5316 Bluejay Rd, Lynnfield, MA 01940
Zhenyu Zhu Phones & Addresses
Lynnfield, MA
21 Goldsmith Ave, Beverly, MA 01915 978-9691230
42 Beckford St, Beverly, MA 01915
Ipswich, MA
948 Bellevue Pl, Jackson, MS 39202
21 Goldsmith Ave, Beverly, MA 01915
Education
Degree:
High school graduate or higher
Mentions for Zhenyu C Zhu
Publications & IP owners
Us Patents
Method For Cloning And Expression Of Bpml Restriction Endonuclease In E. Coli
US Patent:
6413758, Jul 2, 2002
Filed:
Oct 20, 2000
Appl. No.:
09/693146
Inventors:
Jian-ping Xiao - Wenham MA
Zhenyu Zhu - Beverly MA
Zhenyu Zhu - Beverly MA
Assignee:
New England Biolabs, Inc. - Beverly MA
International Classification:
C12N 922
US Classification:
435199, 4352523, 4353201, 536 232
Abstract:
The present invention relates to recombinant DNA which encodes the BpmI restriction endonuclease as well as BpmI methyltransferase, expression of BpmI restriction endonuclease from cells containing the recombinant DNA. BpmI endonuclease is a fusion of two distinct elements with a possible structural domains of restriction-methylation-specificity (R-M-S). This domain organization is analogous to the type I restriction-modification system with three distinct subunits, restriction, methylation, and specificity (R, M, and S). Because BpmI is quite distinct to other type IIs restriction enzymes, it is proposed that BpmI belongs to a subgroup of type II restriction enzymes called type IIf (f stands for fusion of restriction-modification-specificity domains). The Type IIf group of restriction enzyme includes Eco57I, BpmI, GsuI, BseRI and some other restriction enzymes that cut downstream sequences at long distance, 10-20 bp downstream of recognition sequence, such as MmeI (N20/N18)).
Method For Cloning And Expression Of Asisi Restriction Endonuclease And Asisi Methylase In E. Coli
US Patent:
6514737, Feb 4, 2003
Filed:
Aug 20, 2001
Appl. No.:
09/933313
Inventors:
Zhenyu Zhu - Beverly MA
Assignee:
New England Biolabs, Inc. - Beverly MA
International Classification:
C12N 912
US Classification:
435194
Abstract:
The present invention relates to recombinant DNA which encodes the AsiSI restriction endonuclease as well as AsiSI methylase, expression of AsiSI restriction endonuclease and AsiSI methylase in cells containing the recombinant DNA.
Method For Cloning And Expression Of Bsmai Restriction Endonuclease And Bsmai Methylase In E. Coli
US Patent:
6596524, Jul 22, 2003
Filed:
Sep 20, 2001
Appl. No.:
09/957005
Inventors:
Zhenyu Zhu - Beverly MA
Jing Zhou - Beverly MA
Jing Zhou - Beverly MA
Assignee:
New England Biolabs, Inc. - Beverly MA
International Classification:
C12N 922
US Classification:
435199, 4353201, 43525233, 536 232
Abstract:
The present invention relates to recombinant DNA which encodes the BsmAI restriction endonuclease as well as BsmAI methylase, expression of BsmAI restriction endonuclease and BsmAI methylase in cells containing the recombinant DNA, and purification of BsmAI endonuclease to near homogeneity.
Method For Cloning And Expression Of Bsai Restriction Endonuclease And Bsai Methylase In E. Coli
US Patent:
6723546, Apr 20, 2004
Filed:
Mar 26, 2002
Appl. No.:
10/106275
Inventors:
Zhenyu Zhu - Beverly MA
Assignee:
New England Biolabs, Inc. - Beverly MA
International Classification:
C12N 922
US Classification:
435194, 4353201, 43525233, 536 232
Abstract:
The present invention relates to recombinant DNA which encodes the BsaI restriction endonuclease as well as BsaI methylase, expression of BsaI restriction endonuclease and BsaI methylase in cells containing the recombinant DNA, and purification of BsaI restriction endonuclease to near homogeneity.
Method For Cloning And Expression Of Tth111Ii Restriction Endonuclease-Methylase In E. Coli
US Patent:
6919194, Jul 19, 2005
Filed:
Jan 8, 2003
Appl. No.:
10/338731
Inventors:
Zhenyu Zhu - Beverly MA, US
Derek Robinson - Boxford MA, US
Jack Benner - South Hamilton MA, US
Derek Robinson - Boxford MA, US
Jack Benner - South Hamilton MA, US
Assignee:
New England Biolabs, Inc. - Beverly MA
International Classification:
C12N009/22
C12N015/55
C12N015/55
US Classification:
435199, 4353201, 4352523, 536 232
Abstract:
The present invention relates to recombinant DNA which encodes the Tth111II restriction endonuclease-methylase fusion protein (Tth111IIRM), expression of Tth111II restriction endonuclease-methylase fusion protein in cells containing the recombinant DNA, and purification of Tth111II endonuclease-methylase fusion protein to near homogeneity.
Nicking Endonuclease Methods And Compositions
US Patent:
7820424, Oct 26, 2010
Filed:
Jul 22, 2005
Appl. No.:
11/631438
Inventors:
Zhenyu Zhu - Beverly MA, US
Timothy Meixsell - Topsfield MA, US
Timothy Meixsell - Topsfield MA, US
Assignee:
New England Biolabs, Inc. - Ipswich MA
International Classification:
C12N 9/16
C07K 14/00
C12P 21/00
C12N 15/00
C12N 1/21
C12N 5/10
C12Q 1/44
C07H 21/00
C07K 14/00
C12P 21/00
C12N 15/00
C12N 1/21
C12N 5/10
C12Q 1/44
C07H 21/00
US Classification:
435196, 435 19, 435 691, 4353201, 4352523, 435325, 530350, 536 232
Abstract:
A nicking endonuclease is described which has an amino acid sequence with at least 70% identity to SEQ ID NO:6 and comprising a mutation at least one of an arginine or glutamic acid corresponding to position 507 and position 546 respectively in SEQ ID NO:6.
Method For Cloning And Expression Of Stui Restriction Endonuclease And Stui Methylase In
US Patent:
8058029, Nov 15, 2011
Filed:
Feb 27, 2007
Appl. No.:
12/279359
Inventors:
Zhenyu Zhu - Beverly MA, US
Assignee:
New England Biolabs, Inc. - Ipswich MA
International Classification:
C12P 21/04
C12N 15/11
C12N 15/00
C12N 1/20
C12N 15/11
C12N 15/00
C12N 1/20
US Classification:
435 691, 536 232, 4353201, 43525235
Abstract:
The present invention relates to compositions including: (1) isolated DNA encoding the StuI restriction endonuclease and isolated DNA encoding cognate and non-cognate methylase; (2) vectors and cells containing the isolated DNA; and (3) methods for producing the StuI restriction endonuclease.
Variant Of Kpni Restriction Endonuclease
US Patent:
8119382, Feb 21, 2012
Filed:
Aug 18, 2006
Appl. No.:
12/065384
Inventors:
Valakunja Nagaraja - Bangalore, IN
Matheshwaran Saravanan - Bangalore, IN
Zhenyu Zhu - Beverly MA, US
Matheshwaran Saravanan - Bangalore, IN
Zhenyu Zhu - Beverly MA, US
Assignee:
New England Biolabs, Inc. - Ipswich MA
Indian Institute of Science - Bangalore
Indian Institute of Science - Bangalore
International Classification:
C12N 9/22
US Classification:
435199, 435193
Abstract:
Methods are provided for making restriction endonucleases with reduced star activity by one or more targeted mutations to a catalytic site within the restriction endonuclease. Examples of modifications to restriction endonucleases with significant sequence identity with KpnI are provided and reduced star activity demonstrated.
Possible Relatives
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