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Zhihua LiuNew York, NY

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Zhihua Liu Photo 17

Senior Scientist, Analytical Cmc Lead

Location:
Princeton, NJ
Industry:
Pharmaceuticals
Work:
Bristol-Myers Squibb
Senior Scientist, Analytical Cmc Lead Princeton University Mar 2011 - Jan 2014
Postdoctoral Research Investigator
Education:
University of Arizona 2005 - 2010
Doctorates, Doctor of Philosophy, Chemistry, Organic Chemistry China Pharmaceutical University 1999 - 2003
Bachelors
Skills:
Protein Purification, Protein Chemistry, Lc Ms, Antibodies, Purification, Mass Spectrometry, Tissue Culture, Peptide Synthesis, Calorimetry, Laboratory, Flow Cytometry, Bioinformatics, Nmr, Organic Synthesis, Uv/Vis, Organic Chemistry, Spectroscopy, Chemistry, Hplc, Organometallic Chemistry, Ir, Fluorescence Spectroscopy, Medicinal Chemistry, Biochemistry, Fluorescence, Assay Development, Protein Expression, Drug Discovery, Western Blotting, In Vitro, Cell, Elisa, Sds Page, Peptides, Characterization, R&D, Gmp, Pcr, Ion Chromatography
Interests:
Children
Environment
Science and Technology
Disaster and Humanitarian Relief
Health
Zhihua Liu Photo 18

Postdoctoral Fellow

Work:
Geographic Information Science Center of Excellence South Dakota State University
Postdoctoral Fellow
Zhihua Liu Photo 19

Zhihua Liu

Publications & IP owners

Us Patents

Diarylheptanoid Compounds And Uses Thereof

US Patent:
2005021, Sep 29, 2005
Filed:
Mar 8, 2005
Appl. No.:
11/075275
Inventors:
M. Mohamed Rafi - Highland Park NJ, US
Zhihua Liu - Howell NJ, US
Robert Rosen - Monroe Township NJ, US
Sharon Rosen - , US
Chi-Tang Ho - East Brunswick NJ, US
International Classification:
A61K031/22
A61K031/12
US Classification:
514546000, 514690000
Abstract:
The present invention relates to diarylheptanoid compounds and compositions comprising a diarylheptanoid compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof one or more diarylheptanoid compounds. In particular, the invention relates to methods for preventing or treating cancer or an inflammatory disorder by administering to a subject in need thereof one or more diarylheptanoid compounds. The present invention further relates to articles of manufacture comprising one or more diarylheptanoid compounds.

Peptides Imparting Umami, Salt, Dairy And Bitter Flavor

US Patent:
2009014, Jun 4, 2009
Filed:
Dec 3, 2007
Appl. No.:
11/949438
Inventors:
Laurence Trinnaman - Montvale NJ, US
Zhihua Liu - East Brunswick NJ, US
Zhen Chen - Aberdeen NJ, US
International Classification:
A61K 47/42
A23L 1/227
US Classification:
514773, 426537
Abstract:
The invention relates to compositions and methods of using the flavor active peptides, Lys-Ile-His-Pro-Phe (SEQ ID NO:1), Gly-Pro-Phe-Pro-Ile (SEQ ID NO:2), and Lys-Lys-Tyr-Lys-Val-Pro-Gln (SEQ ID NO:3), to impart a bitter, salt, dairy or umami flavor to food or pharmaceutical products. In particular embodiments, the Lys-Lys-Tyr-Lys-Val-Pro-Gln (SEQ ID NO:3) peptide further imparts a vegetable, brothy, or bready flavor.

Flavor-Enhancing Amide Compounds

US Patent:
2011028, Nov 17, 2011
Filed:
May 12, 2010
Appl. No.:
12/778622
Inventors:
Karunananda Bombuwala - Nanuet NY, US
Adam Jan Janczuk - Parlin NJ, US
Kenneth Kraut - Union Beach NJ, US
Zhihua Liu - East Brunswick NJ, US
Neelima Mannava - Manalapan NJ, US
Hou Wu - East Brunswick NJ, US
Ying Yang - Holmdel NJ, US
International Classification:
A61K 9/68
A61K 31/16
A61K 8/18
A23L 1/226
A23G 4/00
US Classification:
424 48, 426534, 426 3, 424 49, 514613
Abstract:
The present invention has discovered that amide compounds represented by Formula I set forth below have unexpected and advantageous flavor enhancement and modification properties:

Flavor Composition Containing Flavone Glycosides

US Patent:
2012025, Oct 4, 2012
Filed:
Apr 1, 2011
Appl. No.:
13/078526
Inventors:
Kathryn Bardsley - Howell NJ, US
Bryan Scott Delchamps - North Brunswick NJ, US
Zhihua Liu - East Brunswick NJ, US
Neelima Mannava - Manalapan NJ, US
Hou Wu - East Brunswick NJ, US
International Classification:
A61K 8/18
A61K 36/906
A61K 31/70
A23G 4/00
A23L 1/22
A61K 36/67
A61K 36/81
US Classification:
424 49, 424734, 424756, 424760, 426 3, 426533, 514 27
Abstract:
The present invention has discovered that flavone glycosides represented by Formula I set forth below have unexpected and advantageous flavor enhancement and modification properties:

Flavor-Enhancing Amide Compounds

US Patent:
2013001, Jan 10, 2013
Filed:
Jul 8, 2011
Appl. No.:
13/178550
Inventors:
Adam Jan Janczuk - Old Bridge NJ, US
Zhihua Liu - East Brunswick NJ, US
International Classification:
A61K 8/40
A23L 1/226
A61Q 11/00
A61K 31/16
C07C 233/09
A61K 8/46
A61K 31/70
US Classification:
424 49, 424 57, 426 3, 426534, 514 47, 514627, 564204
Abstract:
The present invention has discovered that amide compounds represented by Formula I set forth below and isomers thereof have unexpected and advantageous flavor enhancement and modification properties:The amide compounds of the present invention can be used to enhance or modify the flavor of orally consumable compositions, such as foodstuff, chewing gums, dental and oral hygiene products, and medicinal products.

Transglucosylated Rubus Suavissimus Extract And Methods Of Preparation And Use

US Patent:
2016018, Jun 30, 2016
Filed:
Dec 9, 2015
Appl. No.:
14/963556
Inventors:
Hou WU - East Brunswick NJ, US
Jung-A KIM - Edgewater NJ, US
Hsi-Wen CHIN - Tinton Falls NJ, US
Zhihua LIU - East Brunswick NJ, US
Assignee:
INTERNATIONAL FLAVORS & FRAGRANCES INC. - NEW YORK NY
International Classification:
A23L 1/226
A23L 2/60
A23L 1/236
Abstract:
Transglucosylated extract for enhancing the mouthfeel, in particular sugary mouthfeel, of a consumable is provided as is a consumable containing the transglucosylated extract and further a method of producing the transglucosylated extract.

Transglucosylated Rubus Suavissimus Extract And Methods Of Preparation And Use

US Patent:
2015030, Oct 29, 2015
Filed:
Dec 16, 2014
Appl. No.:
14/571723
Inventors:
- NEW YORK NY, US
Jung-A Kim - Edgewater NJ, US
Hsi-Wen Chin - Tinton Falls NJ, US
Zhihua Liu - East Brunswick NJ, US
International Classification:
A23L 1/236
A23L 2/60
Abstract:
Transglucosylated extract for enhancing the mouthfeel, in particular sugary mouthfeel, of a consumable is provided as is a consumable containing the transglucosylated extract and further a method of producing the transglucosylated extract.

Possible Relatives

Cynthia S Liu  David Y Liu  Dean Liu  Da J Liu  Debbie Y Liu  Dan Liu  Zhihua Xu  Zhihua Zhang  Zhihua M Shi 

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