Debashis Ghosh, 6381 Heritage Ave, Ashland, MA 01721

8386027, Feb 26, 2013

Apr 25, 2008

12/110034

Han Chuang - Canton MA, US
Juan P. Eslava - Auburn MA, US
James P. Hurley - Canton MA, US
Debashis Ghosh - Ashland MA, US
Keith Krystyniak - Chelmsford MA, US
Scott C. Kellogg - Mattapoisett MA, US

Echo Therapeutics, Inc. - Philadelphia PA

A61B 5/05
A61B 5/00
A61B 17/20
A61N 1/30
A61N 1/00

600547, 600556, 604 19, 604 22, 607 2, 607 3, 607 62

Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. The feedback control mechanism may be an internal feedback control mechanism or an external feedback control. The kit contains the controlled abrasion-device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time, until the desired level of permeability is reached. Then the abrasion device is removed, and a drug delivery composition or device or an analyte sensor is applied to the treated site.

2013013, May 30, 2013

Jan 22, 2013

13/746673

Echo Therapeutics, Inc. - Franklin MA, US
Juan P. Eslava - Boylston MA, US
James P. Hurley - Foxboro MA, US
Debashis Ghosh - Ashland MA, US
Keith Krystyniak - Chelmsford MA, US
Scott C. Kellogg - Mattapoisett MA, US

ECHO THERAPEUTICS, INC. - Franklin MA

A61B 18/14
A61N 1/30
A61B 5/145

600364, 600309, 600365, 604 20, 606 41

Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. Preferably the feedback control mechanism is an internal feedback control mechanism. In this embodiment, the abrasive tip contains two electrodes, i.e. both the source electrode and the return electrode. In another embodiment, the feedback control mechanism is an external feedback control. In the preferred embodiment for external feedback control, the device contains a co-axial or concentric arrangement of the two electrodes. In this embodiment, the abrasive tip contains the source electrode and the return electrode is located at the proximal end of the hand piece. The abrasive tip can be made of any material with a surface that can abrade skin. The material can be conductive or non-conductive. The controlled abrasion device may be provided in a kit, where the kit contains the device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time. The desired level of skin impedance, and thus the resulting permeability of the treated site, can be set at a predetermined value. Alternatively, the level of skin impedance can be selected based on the desired level of skin integrity, the subject's sensation of discomfort, or the duration of the application. The device contains a control mechanism which uses an appropriate algorithm or signal processing on the conductivity information provided by the electrodes to determine when the desired level of skin permeability has been reached. Once the desired level has been reached, the abrasion device is removed and either a drug delivery composition or device or an analyte sensor is applied to the treated site.