Inventors:
Kurt Roinestad - Yonkers NY
Frank S. Cheng - Park Ridge NJ
Philip J. Palermo - Bethel CT
Kevin Bynum - Long Island City NY
Assignee:
Delphian Technology, Inc. - Woburn MA
International Classification:
G01N 2101
US Classification:
436164, 73866, 738665, 422 8201, 422 8205, 422 8209, 422 8211, 436151, 436173, 436181
Abstract:
The present invention relates to an improvement in a detection system used for continuously measuring the release of a drug from a pharmaceutical dosage form comprising a singular dissolution vessel or multiple dissolution vessels containing a dissolution medium and a measuring device for detecting the amount of drug released at a given time, the improvement comprising a mixing shaft and a probe placed within the mixing shaft or outside the individual dissolution vessels, the probe capable of measuring the dissolution characteristics using UV, IR, near-IR, fluorescence, electrochemical, and Raman spectroscopy techniques. The present invention also relates to a method for predicting the dissolution curve provided by a controlled release pharmaceutical dosage form comprising taking continuous measurements of the amount of drug released from a dosage form for a portion of the time over which the drug is expected to be released and predicting the remainder of the dissolution curve based on the values obtained.
