Inventors:
Robert R. Wilkening - Maplewood NJ, US
James M. Apgar - Highland Park NJ, US
Tesfaye Biftu - Freehold NJ, US
Danqing Feng - Green Brook NJ, US
Xiaoxia Qian - New York NY, US
Lan Wei - Edison NJ, US
International Classification:
A61K 31/519
C07D 498/04
C07D 409/04
A61K 31/4162
A61K 31/424
A61K 31/404
A61K 31/4985
A61K 31/4188
A61P 3/10
A61P 3/06
A61P 3/04
A61P 9/10
A61P 1/02
A61P 29/00
A61P 1/18
A61P 25/28
A61P 9/00
A61P 37/06
A61P 31/18
A61P 35/04
A61P 15/16
A61P 19/10
A61P 25/22
A61P 5/28
A61P 13/12
A61P 7/00
A61P 5/00
A61P 27/02
A61P 37/00
A61P 9/08
C07D 487/04
US Classification:
514249, 5483605, 548218, 548465, 544280, 544279, 544350, 514406, 514407, 514375, 514414, 5142651, 5142641, 5483031, 514393
Abstract:
The present invention is directed to novel substituted aminotetrahydrothiopyrans and derivatives thereof of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.