Lin Chen, 60841 Wiladonda Dr, La Canada, CA 91011

8076070, Dec 13, 2011

Aug 6, 2009

12/537138

Lin Chen - Los Angeles CA, US
Reza Kalhor - Los Angeles CA, US

University of Southern California - Los Angeles CA

C12Q 1/68
G01N 33/53
C12P 19/34
C07H 21/00
C07H 21/02
C07H 21/04

435 6, 435 71, 435 912, 536 221, 536 231, 536 243

The invention relates to the use of GCC (Genome Conformation Capture) technology in determining the three dimensional arrangement of an entire genome.

8227571, Jul 24, 2012

Dec 11, 2008

12/316309

Lin Chen - Superior CO, US
Yeun-Kwei Han - Louisville CO, US
Christopher R. Roberts - Berthoud CO, US

Roche Palo Alto LLC - South San Francisco CA

C07K 14/00

530324, 530308, 530338

The present invention relates to the preparation of insulinotropic peptides that are synthesized using a solid and solution phase (“hybrid”) approach. Generally, the approach includes synthesizing three different peptide intermediate fragments using solid phase chemistry. Solution phase chemistry is then used to add additional amino acid material to the third fragment which is then coupled to the second fragment and then the first fragment in solution. Alternatively, a different second fragment is coupled to the first fragment in the solid phase. Then, solution phase chemistry is then used to add additional amino acid material to a different third fragment. Subsequently, this different third fragment is coupled to the coupled first and different second fragment in the solution phase. The use of a pseudoproline in one of the fragments eases solid phase synthesis of that fragment and also eases subsequent solution phase coupling of this fragment to the other fragments. The present invention is very useful for forming insulinotropic peptides such as GLP-1(7-36) and its natural and non-natural counterparts.

2002018, Dec 5, 2002

Jun 4, 2001

09/871632

Lin Chen - La Canada CA, US

G09G005/02

345/591000

A method of establishing a color image space model including the steps of: (a) setting a standard color card containing a series of reference colors for use as a color data bank, and then setting a table of relative adjectives; (b) setting a color comment questionnaire subject to the standard color card and table of relative objectives thus obtained; (c) selecting at least one particular group people to make an investigation subject to the set color comment questionnaire, and then collecting and arranging the investigation result thus obtained so as to set up effective statistic data; and (d) using an analysis mode to compute the effective statistic data thus obtained, so as to establish a specific color image space model.

2006016, Jul 20, 2006

Oct 14, 2005

11/251643

Lin Chen - Boulder CO, US
Aidong Han - Boulder CO, US
Ju He - Boulder CO, US

G06F 19/00
C12N 9/16
A61K 31/404

435196000, 514419000, 702019000

Disclosed are the three-dimensional structures of two complexes: a Cabin1/MEF2B/DNA complex and a MITR/MEF2B/DNA complex. Also disclosed are methods of using such structures and models derived therefrom in structure-based design methods to identify regulators of the interaction of MEF2 with its cognate ligands/corepressors, to compounds that can be designed or identified based on the knowledge of such structures and models, and to methods of using such compounds in therapeutic methods. Also disclosed are peptide and non-peptide regulatory compounds that regulate, and preferably inhibit, MEF2.

2008000, Jan 3, 2008

Jun 21, 2007

11/821017

Christopher Roberts - Berthoud CO, US
Lin Chen - Superior CO, US
Yeun-Kwei Han - Louisville CO, US

C07K 1/10
C07K 1/00
C07K 5/00

530330000, 530333000

The present invention relates to the preparation of insulinotropic peptides that are synthesized using a solid and solution phase (“hybrid”) approach. Generally, the approach includes synthesizing three different peptide intermediate fragments using solid phase chemistry. Solution phase chemistry is then used to add additional amino acid material to one of the fragments. The fragments are then coupled together in the solid solution phase. The use of a pseudoproline in one of the fragments eases solid phase synthesis of that fragment and also eases subsequent solution phase coupling of this fragment to other fragments. The present invention is very useful for forming insulinotropic peptides such as GLP-1(7-36) and its natural and non-natural counterparts.

2008028, Nov 20, 2008

Dec 20, 2007

12/004265

Lin Chen - Superior CO, US
Yeun-Kwei Han - Louisville CO, US
Christopher R. Roberts - Berthoud CO, US

C07K 2/00
C07C 69/616
C07K 5/12

530317, 560 39

Methods for the synthesis of cyclic peptides are provided, as well as novel dipeptide compounds. The methods include the solid phase synthesis of a dipeptide, which is the coupled to a second peptide in a solid phase reaction. The peptide is then cyclized following the coupling reaction. The methods and dipeptides are particularly useful for the synthesis of MC-4 receptor agonist peptides.

2010013, Jun 3, 2010

Dec 3, 2009

12/630002

Lin Chen - Superior CO, US

C07K 14/435
C07K 7/08
C07K 7/06
C07K 5/103

530324, 530326, 530327, 530330

This application discloses processes for synthesizing human relaxin Chain B for treatment of diseases mediated by relaxin. This application in particular discloses processes of synthesizing the Chain B of human relaxin using a solid and solution phase (“hybrid”) approach. Generally, the approach includes synthesizing three different peptide intermediate fragments using solid phase chemistry. Solution phase chemistry is then used to couple the fragments.

2010029, Nov 18, 2010

Apr 30, 2010

12/770907

LIN CHEN - SUPERIOR CO, US
YEUN-KWEI HAN - LOUISVILLE CO, US
CHRISTOPHER R. ROBERTS - BETHOUD CO, US

C07K 14/00
C07K 7/08

530324, 530326, 530327, 530328

The present invention relates to the preparation of insulinotropic peptides that are synthesized using a solid and solution phase (“hybrid”) approach. Generally, the approach includes synthesizing three different peptide intermediate fragments using solid phase chemistry. Solution phase chemistry is then used to couple the second fragment and the first fragment. Alternatively, a different second fragment is coupled to a first fragment in the solid phase. Then, solution phase chemistry is then used to add the third fragment, whereby the third fragment is coupled to the coupled first and second fragments in the solution phase. The present invention is very useful for forming insulinotropic peptides such as GLP-1(7-36) and its natural and non-natural counterparts.