Manuka G Ghosh, 6450628 Lakeside Dr, Granger, IN 46530

Manuka Ghosh Phones & Addresses

Granger, IN

South Bend, IN

Mishawaka, IN

Madison, CT

Trenton, NJ

Branford, CT

Plainsboro, NJ

Clifton Heights, PA

Social networks

Manuka G Ghosh

Work

Company: Hsiri therapeutics 2011 Address: IN Position: Research scientist

Education

School / High School: University of Notre Dame 1991 to 1995

Skills

Drug Discovery • Drug Design • Drug Development • Chemistry • Medicinal Chemistry • Organic Chemistry • Organic Synthesis • Carbohydrate Chemistry • Amino Acids/Peptides • Gpcrs • Neuroscience • Pharmacology • Pharmacokinetics • Oncology • Infection • Analytical Chemistry • Nmr • Chromatography • Molecular Modeling • Data Analysis • Dmpk • Adme • Biotechnology • Lead Change • Formulation • Drug Delivery • Cro • Cro Management • Nuclear Magnetic Resonance • Pharmaceutical Industry • Life Sciences • High Performance Liquid Chromatography • Drug Metabolism • Parallel Synthesis • Science

Languages

English • Bengali • Hindi

Industries

Pharmaceuticals

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Manuka Ghosh resumes & CV records

Resumes

Manuka Ghosh

Location:

103 Nursery Ln, Madison, CT 06443

Industry:

Pharmaceuticals

Work:

Hsiri Therapeutics - IN since 2011
Research Scientist Neurogen Corporation Dec 1999 - 2008
Research Fellow II Intercardia, Inc. 1996 - 1999
Research Scientist

Education:

University of Notre Dame 1991 - 1995
Calcutta University, Kolkata
Master of Science, Masters Rajabazar Science College
Master of Science, Masters Jadavpur University
Doctorates, Doctor of Philosophy Scottish Church College
Bachelors, Bachelor of Science

Skills:

Drug Discovery, Drug Design, Drug Development, Chemistry, Medicinal Chemistry, Organic Chemistry, Organic Synthesis, Carbohydrate Chemistry, Amino Acids/Peptides, Gpcrs, Neuroscience, Pharmacology, Pharmacokinetics, Oncology, Infection, Analytical Chemistry, Nmr, Chromatography, Molecular Modeling, Data Analysis, Dmpk, Adme, Biotechnology, Lead Change, Formulation, Drug Delivery, Cro, Cro Management, Nuclear Magnetic Resonance, Pharmaceutical Industry, Life Sciences, High Performance Liquid Chromatography, Drug Metabolism, Parallel Synthesis, Science

Languages:

English
Bengali
Hindi

Publications & IP owners

Us Patents

1H-Pyrrolo [3,2-B] Pyridine-3-Carboxylic Acid Amines As Gabaa Receptor Ligands

US Patent:

6673811, Jan 6, 2004

Filed:

Nov 19, 2002

Appl. No.:

10/299199

Inventors:

George D. Maynard - Clinton CT
Manuka Ghosh - Branford CT
Christopher J. ODonnell - Mystic CT

Assignee:

Neurogen Corporation - Branford CT
Pfizer, Inc. - New York NY

International Classification:

A61K 314965

US Classification:

514300, 51425502, 544405, 546113

Abstract:

Disclosed are 1H-Pyrrolo[3,2-b]pyridine-3-carboxylic acid amides that bind to the benzodiazepine site of GABA receptors. Such compounds can be used to modulate ligand binding to GABA receptors in vivo and in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals, and livestock animals.

Benzimidazole And Pyridylimidazole Derivatives

US Patent:

6916819, Jul 12, 2005

Filed:

Dec 21, 2001

Appl. No.:

10/038069

Inventors:

Guiying Li - Branford CT, US
John M. Peterson - Madison CT, US
Pamela Albaugh - Carmel IN, US
Kevin S. Currie - North Branford CT, US
Guolin Cai - Thousand Oaks CA, US
Linda M. Gustavson - Guilford CT, US
Kyungae Lee - Guilford CT, US
Alan Hutchison - Madison CT, US
Vinod Singh - Kanpur, IN
George D. Maynard - Clinton CT, US
Jun Yuan - Guilford CT, US
Ling Hong Xie - Guilford CT, US
Manuka Ghosh - Branford CT, US
Nian Liu - North Branford CT, US

Assignee:

Neurogen Corporation - Branford CT

International Classification:

C07D403/12
C07D403/14
C07D401/14
A61K031/4184
A61P025/24

US Classification:

514256, 514372, 514374, 514378, 514394, 514395, 514339, 514307, 544333, 206570, 546144, 546167, 5462697, 5462714, 5462724, 5462734, 5462737, 548181, 548206, 548235, 548247, 548254, 548255, 5483047, 5483061

Abstract:

This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAreceptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAreceptors in tissue sections.

Heteroaryl Substituted Fused Bicyclic Heteroaryl Compound As Gabaa Receptor Ligands

US Patent:

6936617, Aug 30, 2005

Filed:

Jul 12, 2002

Appl. No.:

10/194852

Inventors:

Alan Hutchison - Madison CT, US
George Maynard - Clinton CT, US
Pamela Albaugh - Carmel IN, US
Linghong Xie - Guilford CT, US
Jun Yuan - Guilford CT, US
Scott Mitchell - East Haven CT, US
Vinod Singh - Kanpur, IN
Manuka Ghosh - Madison CT, US
Guiying Li - Branford CT, US
Nian Liu - North Branford CT, US

Assignee:

Neurogen Corporation - Branford CT

International Classification:

C07D471/04
C07D487/04
C07D513/04
A61K031/437

US Classification:

514256, 514300, 544333, 546121

Abstract:

This invention relates to heteroaryl substituted fused bicyclic heteroaryl compounds, such as heteroaryl substituted imidazopyridines, imidazopyrazines, imidazopyridizines, imidazopyrimidines, and imidazothiazoles, which may be described by Formula I or Formula II: The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAreceptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Processes for preparing compounds of Formula I and Formula II are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I or Formula II in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAreceptors in tissue sections.

Substituted 1-Benzyl-4-Substituted Piperazine Analogues

US Patent:

7253168, Aug 7, 2007

Filed:

Apr 6, 2005

Appl. No.:

11/100355

Inventors:

Alan J. Hutchison - Madison CT, US
Bertrand L. Chenard - Waterford CT, US
James G. Tarrant - Hamden CT, US
Guiying Li - Branford CT, US
Manuka Ghosh - Madison CT, US
George P. Luke - Clinton CT, US
John M. Peterson - Durham CT, US
Wallace C. Pringle - Guilford CT, US
Mary-Margaret E. O'Donnell - Shelton CT, US
Kyungae Lee - Newton MA, US
Linda M. Gustavson - Ringoes NJ, US
Dario Doller - Wallingford CT, US

Assignee:

Neurogen Corporation - Branford CT

International Classification:

A07D 241/36
A61K 31/498
A61P 3/04
A61P 3/10
C07D 239/70
C07D 487/08
C07D 471/14
A61K 31/517
A61K 31/407

US Classification:

514249, 544349, 544253, 544355, 544238, 544295, 544357, 548453, 514256, 514414, 514314, 514338, 51425211, 514307, 51425202, 546168, 5462767, 546146

Abstract:

Compounds of Formula I are provided, in which variables are as described herein:Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e. g. , receptor localization studies).

Benzimidazole And Pyridylimidazole Derivatives

US Patent:

7300945, Nov 27, 2007

Filed:

Jul 12, 2005

Appl. No.:

11/179458

Inventors:

Guiying Li - Branford CT, US
Pamela Albaugh - Carlsbad CA, US
Kevin S. Currie - North Branford CT, US
Guolin Cai - Thousand Oaks CA, US
Linda M. Gustavson - Ringoes NJ, US
Kyungae Lee - Newton MA, US
Alan Hutchison - Madison CT, US
George D. Maynard - Clinton CT, US
Jun Yuan - Guilford CT, US
Ling Hong Xie - Guilford CT, US
Manuka Ghosh - Madison CT, US
Nian Liu - Edison NJ, US
George P. Luke - Clinton CT, US
Scott Mitchell - East Haven CT, US
Martin Patrick Allen - North Stonington CT, US
Spiros Liras - Stonington CT, US

Assignee:

Neurogen Corporation - Branford CT

International Classification:

C07D 471/04
A61K 31/437

US Classification:

514303, 546118, 206570

Abstract:

This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula IThe invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAreceptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAreceptors in tissue sections.

4,5-Disubstituted-2-Aryl Pyrimidines

US Patent:

7482350, Jan 27, 2009

Filed:

May 6, 2005

Appl. No.:

11/123755

Inventors:

George D. Maynard - Clinton CT, US
Manuka Ghosh - Madison CT, US
Jun Yuan - Guilford CT, US
Kevin S. Currie - North Branford CT, US
Scott Mitchell - East Haven CT, US
Qin Guo - Branford CT, US
He Zhao - Branford CT, US

Assignee:

Neurogen Corporation - Brandford CT

International Classification:

A01N 43/54
C07D 239/42
C07D 401/04
C07D 403/00

US Classification:

514256, 544295

Abstract:

4,5-disubstituted-2-arylpyrimidines of Formula I and Formula II are provided:.

Benzimidazole And Pyridylimidazole Derivatives

US Patent:

7642267, Jan 5, 2010

Filed:

Nov 19, 2007

Appl. No.:

11/942480

Inventors:

Guiying Li - Branford CT, US
Pamela Albaugh - Carmel IN, US
Kevin S. Currie - North Branford CT, US
Guolin Cai - Thousand Oaks CA, US
Linda M. Gustavson - Guilford CT, US
Kyungae Lee - Guilford CT, US
Alan Hutchison - Madison CT, US
George D. Maynard - Clinton CT, US
Jun Yuan - Guilford CT, US
Ling Hong Xie - Guilford CT, US
Manuka Ghosh - Branford CT, US
Nian Liu - North Branford CT, US
George P. Luke - Clinton CT, US
Scott Mitchell - East Haven CT, US
Martin Patrick Allen - North Stonington CT, US
Spiros Liras - Stonington CT, US

Assignee:

Neurogen Corporation - Branford CT

International Classification:

C07D 471/04
A61K 31/437

US Classification:

5142621, 544262, 544264, 544265, 544277, 5142632

Abstract:

This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I. The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAreceptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate.

2-Phenoxy Pyrimidinone Analogues

US Patent:

8003656, Aug 23, 2011

Filed:

Aug 22, 2007

Appl. No.:

11/895286

Inventors:

Rajagopal Bakthavatchalam - Madison CT, US
Scott M. Capitosti - Middletown CT, US
Jianjun Xu - Branford CT, US
Bertrand L. Chenard - Waterford CT, US
Manuka Ghosh - Madison CT, US
Charles A. Blum - Westbrook CT, US

Assignee:

Neurogen Corporation - Branford CT

International Classification:

C07D 473/04
A61K 31/522
C07D 495/04
C07D 487/04
A61K 31/519
A61P 25/04

US Classification:

5142633, 51426322, 51426334, 5142601, 5142641, 544269, 544267, 544278, 544262, 544279

Abstract:

2-Phenoxy pyrimidinone analogues are provided, of the Formula:.

Possible Relatives

Debalina Ghosh Debashis Ghosh Debashish Ghosh Debjani Ghosh Debaprasad J Ghosh Debraj Ghosh Deepak Ghosh

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