Inventors:
- Gaithersburg MD, US
- Bellinzona, CH
Josephine Mary McAuliffe - Gaithersburg MD, US
Frances Palmer-Hill - Gaithersburg MD, US
Leslie Wachter - Gaithersburg MD, US
Andy Yuan - Gaithersburg MD, US
Qing Zhu - Gaithersburg MD, US
Davide Corti - Bellinzona, CH
Antonio Lanzavecchia - Bellinzona, CH
Barbara Guarino - Bellinzona, CH
Anna DeMarco - Bellinzona, CH
International Classification:
C07K 16/10
A61K 31/13
A61K 39/395
A61K 31/7012
A61K 31/215
A61K 39/42
A61K 45/06
C12P 21/00
G01N 33/569
G01N 33/577
Abstract:
The invention relates to antibodies and binding fragments thereof that are capable of binding to influenza A virus hemagglutinin and neutralizing at least one group 1 subtype and at least 1 group 2 subtype of influenza A virus. In one embodiment, an antibody or binding fragment according to the invention is capable of binding to and/or neutralizing one or more influenza A virus group 1 subtypes selected from H1, H2, H5, H6, H8, H9, H11, H12, H13, H16 and H17 and variants thereof and one or more influenza A virus group 2 subtype selected from H3, H4, H7, H1, 0, H14 and H15 and variants thereof.