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Vincent R Racaniello, 721211 Cooper Rd, Scotch Plains, NJ 07076

Known as:
Vincent Dr Racaniello Vincent P Racaniello Vvincent R Racaniello Vincent Cully Vincent R Rancaniello Vincent Racaneillo
Related to:
Frances Ferrel

Vincent Racaniello Phones & Addresses

1211 Cooper Rd, Scotch Plains, NJ 07076   

Boston, MA   

20 White Ave, Lavallette, NJ 08735   

New York, NY   

San Antonio, TX   

Upper Saddle River, NJ   

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Vincent R Racaniello

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Work

Company: Columbia university in the city of new york Sep 1982 Position: Professor

Education

Degree: Doctorates, Doctor of Philosophy School / High School: Icahn School of Medicine at Mount Sinai 1975 to 1979

Skills

Virology • Molecular Biology • Microbiology • Cell Culture • Genetics • Cell Biology • Science • Research • Pcr • Immunology • Teaching • Biochemistry • Infectious Diseases • Laboratory • Animal Models • Life Sciences • Scientific Writing • Science Communication • Molecular Cloning • Lifesciences • Protein Expression • Medical Education • Podcasting • Medical Research • Molecular Virology • Writing • Medical Microbiology

Languages

Italian • French

Interests

Teaching • Technology • Virology • Microbiology • New Media

Industries

Research
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Mentions for Vincent R Racaniello

Vincent Racaniello resumes & CV records

Resumes

Vincent Racaniello Photo 9

Professor

Location:
1211 Cooper Rd, Scotch Plains, NJ 07076
Industry:
Research
Work:
Columbia University In the City of New York
Professor Massachusetts Institute of Technology (Mit) Nov 1979 - Sep 1982
Postdoctoral Fellow The Mount Sinai Hospital 1975 - 1979
Ph.d Student
Education:
Icahn School of Medicine at Mount Sinai 1975 - 1979
Doctorates, Doctor of Philosophy Cornell University 1970 - 1974
Bachelors, Bachelor of Arts Cornell University
Skills:
Virology, Molecular Biology, Microbiology, Cell Culture, Genetics, Cell Biology, Science, Research, Pcr, Immunology, Teaching, Biochemistry, Infectious Diseases, Laboratory, Animal Models, Life Sciences, Scientific Writing, Science Communication, Molecular Cloning, Lifesciences, Protein Expression, Medical Education, Podcasting, Medical Research, Molecular Virology, Writing, Medical Microbiology
Interests:
Teaching
Technology
Virology
Microbiology
New Media
Languages:
Italian
French

Publications & IP owners

Us Patents

Attenuated Polioviruses

US Patent:
5286640, Feb 15, 1994
Filed:
May 17, 1993
Appl. No.:
8/062046
Inventors:
Jeffrey W. Almond - Reading RG1 5AQ, GB
Michael A. Skinner - Cambridge CB2 2QH, GB
Vincent Racaniello - New York NY
Philip D. Minor - South Mimms Potters Bar Herts EN6 3QG, GB
International Classification:
C12N 704
C12N 1509
C12N 701
A61K 3913
US Classification:
435236
Abstract:
An attenuated enterovirus or rhinovirus, suitable for use as a vaccine, has an attenuating mutation at least at a position which is, or corresponds with, position 479 and/or 482 of poliovirus type 3 Leon strain.

Method Of Producing Rna Viruses From Cdna

US Patent:
5683901, Nov 4, 1997
Filed:
Jun 1, 1995
Appl. No.:
8/458990
Inventors:
Vincent Racaniello - New York NY
Joanne Marie Tatem - Lincoln Park NJ
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
International Classification:
C12N 704
US Classification:
435236
Abstract:
The present invention relates to methods for producing RNA virus cDNA, methods for producing viable, RNA virus and viable, RNA virus produced by those methods. The invention also related to a novel RNA virus cDNA, recombinant DNA molecules containing that cDNA and hosts transformed with those recombinant cDNA molecules. This invention further related to novel methods for screening for variants of a strain 3 poliovirus. This invention also related to methods for increasing the attenuation of a strain poliovirus.

Molecular Cloning Of Genomic And Cdna Sequences Encoding Cellular Receptors For Poliovirus

US Patent:
5753521, May 19, 1998
Filed:
May 19, 1995
Appl. No.:
8/446049
Inventors:
Vincent Racaniello - New York NY
Cathy Mendelsohn - Strasbourg, FR
Frank Costantini - New York NY
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
International Classification:
C07H 2104
C12N 1563
C12N 1581
C12N 1585
US Classification:
435 691
Abstract:
The subject invention provides an isolated nucleic acid molecule which comprises nucleic acid encoding a polypeptide which has the biological activity of a receptor for picornavirus. The subject invention also provides a method which includes the-use of expression vectors in a host vector system for inducing the production of a picornavirus receptor.

Production Of Complementary Dna Representing Rna Viral Sequences By Recombinant Dna Methods And Uses Therefor

US Patent:
4719177, Jan 12, 1988
Filed:
Nov 12, 1981
Appl. No.:
6/320525
Inventors:
David Baltimore - Cambridge MA
Vincent R. Racaniello - Boston MA
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
C12P 1934
C12N 1500
C12N 120
C12N 100
US Classification:
435 91
Abstract:
Methods for producing RNA viral cDNA, such as poliovirus ds cDNA, products thereof, and uses thereof, are described. Poliovirus cDNA is produced, for example, by reverse transcribing poliovirus RNA and subsequently inserting the poliovirus cDNA into bacterial plasmids by genetic-engineering techniques. Transformed bacteria are then cloned and cultured to produce replicated chimeric plasmids containing the cDNA poliovirus. Such poliovirus cDNA is useful in assaying for the presence of poliovirus and in the production of antibodies against poliovirus. It has also been found that full-length poliovirus cDNA is infectious, which means it can be employed in producing altered virus particles for vaccines.

Method For Producing Rna Viruses From Cdna

US Patent:
5580719, Dec 3, 1996
Filed:
Jun 2, 1995
Appl. No.:
8/460080
Inventors:
Vincent Racaniello - New York NY
Joanne M. Tatem - Lincoln Park NJ
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
International Classification:
C12Q 170
US Classification:
435 5
Abstract:
The present invention relates to methods for producing RNA virus cDNA, methods for producing viable, RNA virus and viable, RNA virus produced by those methods. The invention also related to a novel RNA virus cDNA, recombinant DNA molecules containing that cDNA and hosts transformed with those recombinant cDNA molecules. This invention further related to novel methods for screening for variants of a strain 3 poliovirus. This invention also related to methods for increasing the attenuation of a strain poliovirus. This invention provides a vaccine useful for immunizing a subject, for example a human, against infectious poliovirus, wherein the vaccine comprises an effective amount of an RNA virus, produced by transforming a suitable host cell with a recombinant nucleic acid sequence which encodes for the virus: culturing the host cell under conditions which permit the production of virus: and isolating the virus so produced, effective to immunize the subject, and a suitable carrier. Further provided to this invention is a method of immunizing a subject such as a human against infectious poliovirus, wherein the method comprises administering the subject a suitable dose of the vaccine described hereinabove.

Method For Producing Rna Viruses From Cdna

US Patent:
5834302, Nov 10, 1998
Filed:
Jun 5, 1995
Appl. No.:
8/461503
Inventors:
Vincent Racaniello - New York NY
Joanne Marie Tatem - Lincoln Park NJ
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
International Classification:
C12N 1543
US Classification:
4352523
Abstract:
The present invention relates to methods for producing RNA virus cDNA, methods for producing viable, RNA virus and viable, RNA virus produced by those methods. The invention also related to a novel RNA virus cDNA, recombinant DNA molecules containing that cDNA and hosts transformed with those recombinant cDNA molecules. This invention further related to novel methods for screening for variants of a strain 3 poliovirus. This invention also related to methods for increasing the attenuation of a strain poliovirus. This invention provides a vaccine useful for immunizing a subject, for example a human, against infectious poliovirus, wherein the vaccine comprises an effective amount of an RNA virus, produced by transforming a suitable host cell with a recombinant nucleic acid sequence which encodes for the virus: culturing the host cell under conditions which permit the production of virus: and isolating the virus so produced, effective to immunize the subject, and a suitable carrier. Further provided to this invention is a method of immunizing a subject such as a human against infectious poliovirus, wherein the method comprises administering the subject a suitable dose of the vaccine described hereinabove.

Method For Producing Rna Viruses From Cdna

US Patent:
6136570, Oct 24, 2000
Filed:
Jun 5, 1995
Appl. No.:
8/465250
Inventors:
Vincent Racaniello - New York NY
Joanne Marie Tatem - Lincoln Park NJ
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
International Classification:
C12N 1543
US Classification:
435 9151
Abstract:
The present invention relates to methods for producing RNA virus cDNA, methods for producing viable, RNA virus and viable, RNA virus produced by those methods. The invention also related to a novel RNA virus cDNA, recombinant DNA molecules containing that cDNA and hosts transformed with those recombinant cDNA molecules. This invention further related to novel methods for screening for variants of a strain 3 poliovirus. This invention also related to methods for increasing the attenuation of a strain poliovirus. This invention provides a vaccine useful for immunizing a subject, for example a human, against infectious poliovirus, wherein the vaccine comprises an effective amount of an RNA virus, produced by transforming a suitable host cell with a recombinant nucleic acid sequence which encodes for the virus: culturing the host cell under conditions which permit the production of virus: and isolating the virus so produced, effective to immunize the subject, and a suitable carrier. Further provided to this invention is a method of immunizing a subject such as a human against infectious poliovirus, wherein the method comprises administering the subject a suitable dose of the vaccine described hereinabove.

Transgenic Mouse Expressing Dna Sequences Encoding The Human Poliovirus Receptor

US Patent:
5631407, May 20, 1997
Filed:
Jan 14, 1994
Appl. No.:
8/182371
Inventors:
Vincent Racaniello - New York NY
Cathy Mendelsohn - Strasbourg, FR
Frank Costantini - New York NY
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
International Classification:
C12N 500
C12N 1500
C12P 1500
A61K 4900
US Classification:
800 2
Abstract:
The subject invention provides an isolated nucleic acid molecule which comprises nucleic acid encoding a polypeptide which has the biological activity of a receptor for poliovirus and in addition, provides a purified polypeptide which has this activity. The subject invention also provides a method for inducing the production of a polypeptides which includes the use of expression vectors in a host vector system. Therapeutic compositions comprising purified polypeptides which have the biological activity of a receptor for poliovirus are also provided for as are methods of treating and preventing human poliovirus infection. Further, the subject invention provides a method of producing a transgenic animal expressing human poliovirus receptors. The subject invention provides a method of testing the efficacy of a poliovirus receptors vaccine which comprises administering the vaccine to a transgenic animal described above and determining whether the resulting transgenic animal is protected from infection by human picornavirus. Lastly, a method of testing the virulence of a picornavirus vaccine is provided.

Possible Relatives

Jean Racaniello  Vincent G Johnson  Vincent R Stanbro  Vincent Johnston  Vincent J Stanfield  Vincent White  Vincent C Jolly  Vincent Jones  Vincent Stanley  Vincent P Stanton 

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