Wei Chen, 4212569 Carmel Canyon Rd, San Diego, CA 92130

7427940, Sep 23, 2008

Mar 23, 2007

11/690506

Robert Bogdan Staszewski - Garland TX, US
Dirk Leipold - Plano TX, US
Wei Chen - San Diego CA, US

Texas Instruments Incorporated - Dallas TX

H03M 1/12
H03L 7/06

341155, 327269, 327272, 341157

A time-to-digital converter (TDC), a system-on-chip including a TDC, a method of phase detection for use in synthesizing a clock signal and a non-linearity corrector for a TDC. In one embodiment, the TDC includes a chain of delay elements configured to receive a clock signal and generate delayed clock signals. Each one of the delay elements includes: (1) a non-inverting buffer configured to delay the clock signal by about twice a delay of an inverter to provide a buffer-delayed clock signal and (2) a first transmission gate coupled to the non-inverting buffer and configured to delay the clock signal by about the delay of an inverter to provide a first gate-delayed clock signal.

2004000, Jan 15, 2004

Jan 27, 2003

10/353137

Wei Chen - San Diego CA, US
Xiaoli Fu - Carlsbad CA, US
Sherry Nouraini - Vista CA, US
Zhiqing Zhang - Carlsbad CA, US

A61K048/00
A61L009/04
A61K009/14

514/044000, 424/046000

Methods and compostions related to the fields of bacteriology, immunology and gene therapy are provided. In general modified microflora for the delivery of vaccines, allergens and therapeutics to the mucosal surfaces of the respiratory tract are provided. In particular, the compositions and methods are directed at inducing an M-cell mediated immune response to pathogenic diseases. Specifically, methods of vaccine preparation, delivery and mucosal immunization using a Lactic Acid Bacteria (LAB), yeast and LAB that have been modified through fusion with to either present on its cell surface, or secrete, antigenic epitopes derived from pathogenic microorganisms and/or to secrete a therapeutic protein sequence are disclosed.

2004004, Mar 4, 2004

Oct 25, 2002

10/280769

Wei Chen - San Diego CA, US
Xiaoli Fu - Carlsbad CA, US
Sherry Nouraini - Vista CA, US
Zhiqing Zhang - Beijing, CN

A61K048/00

424/093200

Clinical grade vectors comprising transformed microflora vector having at least one transforming nucleic acid sequence containing at least one gene of interest are provided. The transforming nucleic acid encodes for a therapeutic polypeptide that is delivered to the host in need thereof topically, orally, intranasally and/or transderamally. The clinical grade vectors are derived from lactic acid bacteria, yeast and other non-pathogenic microorganisms and have been provided with selective/and or reporter genes that do not rely on antibiotic resistance. Moreover, the clinical grade vectors are provided with phenotypic and/or genotypic traits that limit the ex vivo dissemination of transforming nucleic acid sequence(s). Also provided are methods and compositions useful in treating diseases in animals.

2005007, Apr 7, 2005

Jan 27, 2003

10/353149

Wei Chen - San Diego CA, US
Xiaoli Fu - Carlsbad CA, US
Sherry Nouraini - Vista CA, US
Zhiqing Zhang - Carlsbad CA, US

A61K048/00

514044000

Methods and compositions are provided for in vivo heterologous nucleic acid delivery using genetically modified microflora. Specifically, compositions and related methods for the delivery of heterologous nucleic acids to the intestinal mucosa of animals are provided. Specifically, genetically modified microflora are used to deliver transforming heterologous nucleic acids directly, or genetically modified microflora expressing at least one heterologous nucleic acid are provided. Representative microflora include bacteria, bacterial fusions, and yeast. The heterologous nucleic acid may encode for immunoprotective epitopes (antigens) or other gene therapy applications.

2012021, Aug 23, 2012

Feb 23, 2011

13/032732

Wei Chen - San Diego CA, US
Yucong Tao - San Diego CA, US
Matthew L. Severson - San Diego CA, US
Jeffrey R. Gemar - San Diego CA, US
Chang Yong Yang - Fayetteville NC, US

QUALCOMM Incorporated - San Diego CA

G06F 11/00
H03L 5/00
G01R 31/40
G06F 19/00

714727, 700121, 327333, 32476401, 714E1102

In examples, apparatus and methods are provided for an integrated circuit. The integrated circuit includes a first integrated circuit portion having a main power domain and a second integrated circuit portion having a collapsible power domain. The integrated circuit also has a level shifter having an input coupled to the second circuit portion and an output coupled to the first integrated circuit portion. The level shifter is configured to hold constant the level shifter output when power to the collapsible power domain is collapsed. A quiescent drain current measurement circuit can be coupled to test at least a part of the second integrated circuit portion. A boundary scan register can be coupled between the level shifter output and the first integrated circuit portion. The integrated circuit can also include a power management circuit.

5955323, Sep 21, 1999

Aug 1, 1996

8/691177

Wei Chen - Frazer PA

American Home Products Corporation - Madison NJ

C12P 1934
C12N 120

435 911

This invention relates to a fermentation process for high-yield production of plasmid DNA in E coli strains. In the disclosed process, a slow growth rate of cells is controlled and maintained by an automated nutrient feed scheme based on dissolved oxygen concentration (DOC) and pH. This controlled slow growth rate promotes high plasmid DNA stability during host cell replication. As a result, high yield production of plasmid DNA is achieved.

2022037, Nov 24, 2022

Sep 23, 2020

17/762991

- Wilmington DE, US
Yuwen He - San Diego CA, US
Wei Chen - San Diego CA, US
Hongyu Li - Princeton Junction NJ, US

VID SCALE, INC. - Wilmington DE

H04N 19/117
H04N 19/176
H04N 19/186

A filter may be applied to a subset of components associated with a sample in a coding block. The output of the filter may be used to modify values for other component(s). For example, a filter may be applied to a selected (for example, dominant) component(s). The output of the filter may be used to modify a value for one of the other components (for example, non-dominant components). The output of the filter may be used, for example, after a weighting factor is applied to the filter output, to modify a value for another one of the other components. A joint refinement signal may be obtained, for example, as the filtered output signal minus the filter input signal of the selected component(s). A properly weighted version of the joint refinement signal may be applied to modify the other components.

2022034, Oct 27, 2022

Sep 17, 2020

17/760985

- Wilmington DE, US
Yuwen He - San Diego CA, US
Wei Chen - San Diego CA, US

VID SCALE, INC. - Wilmington DE

H04N 19/119
H04N 19/105
H04N 19/176
H04N 19/159

Systems, methods, and instrumentalities may be used for decoding and/or encoding a coding unit (CD), An intra-prediction mode for a CD may be determined. A split mode may be determined based on the intra-prediction mode, to generate a plurality of sub-partitions in the CU. A prediction for a first sub-partition of the plurality of sub-partitions in the CU may be based on a reference sample in a second sub-partition of the plurality of sub-partitions in the CU. The CU may be decoded and/or encoded, for example, based on the determined split mode.